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Allogenic Fc Domain-Facilitated Uptake of IgG in Nasal Lamina Propria: Friend or Foe for Intranasal CNS Delivery?

Background: The use of therapeutic antibodies for the treatment of neurological diseases is of increasing interest. Nose-to-brain drug delivery is one strategy to bypass the blood brain barrier. The neonatal Fc receptor (FcRn) plays an important role in transepithelial transcytosis of immunoglobulin...

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Detalles Bibliográficos
Autores principales:	Ladel, Simone, Flamm, Johannes, Zadeh, Arghavan Soleimani, Filzwieser, Dorothea, Walter, Julia-Christina, Schlossbauer, Patrick, Kinscherf, Ralf, Lischka, Katharina, Luksch, Harald, Schindowski, Katharina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161100/ https://www.ncbi.nlm.nih.gov/pubmed/30050027 http://dx.doi.org/10.3390/pharmaceutics10030107

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