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Hydrogels of Polycationic Acetohydrazone-Modified Phosphorus Dendrimers for Biomedical Applications: Gelation Studies and Nucleic Acid Loading

In this work, we report the assemblage of hydrogels from phosphorus dendrimers in the presence of biocompatible additives and the study of their interactions with nucleic acids. As precursors for hydrogels, phosphorus dendrimers of generations 1–3 based on the cyclotriphosphazene core and bearing am...

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Autores principales: Apartsin, Evgeny K., Grigoryeva, Alina E., Malrin-Fournol, Audrey, Ryabchikova, Elena I., Venyaminova, Alya G., Mignani, Serge, Caminade, Anne-Marie, Majoral, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161142/
https://www.ncbi.nlm.nih.gov/pubmed/30082671
http://dx.doi.org/10.3390/pharmaceutics10030120
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author Apartsin, Evgeny K.
Grigoryeva, Alina E.
Malrin-Fournol, Audrey
Ryabchikova, Elena I.
Venyaminova, Alya G.
Mignani, Serge
Caminade, Anne-Marie
Majoral, Jean-Pierre
author_facet Apartsin, Evgeny K.
Grigoryeva, Alina E.
Malrin-Fournol, Audrey
Ryabchikova, Elena I.
Venyaminova, Alya G.
Mignani, Serge
Caminade, Anne-Marie
Majoral, Jean-Pierre
author_sort Apartsin, Evgeny K.
collection PubMed
description In this work, we report the assemblage of hydrogels from phosphorus dendrimers in the presence of biocompatible additives and the study of their interactions with nucleic acids. As precursors for hydrogels, phosphorus dendrimers of generations 1–3 based on the cyclotriphosphazene core and bearing ammonium or pyridinium acetohydrazones (Girard reagents) on the periphery have been synthesized. The gelation was done by the incubation of dendrimer solutions in water or phosphate-buffered saline in the presence of biocompatible additives (glucose, glycine or polyethylene glycol) to form physical gels. Physical properties of gels have been shown to depend on the gelation conditions. Transmission electron microscopy revealed structural units and well-developed network structures of the hydrogels. The hydrogels were shown to bind nucleic acids efficiently. In summary, hydrogels of phosphorus dendrimers represent a useful tool for biomedical applications.
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spelling pubmed-61611422018-10-01 Hydrogels of Polycationic Acetohydrazone-Modified Phosphorus Dendrimers for Biomedical Applications: Gelation Studies and Nucleic Acid Loading Apartsin, Evgeny K. Grigoryeva, Alina E. Malrin-Fournol, Audrey Ryabchikova, Elena I. Venyaminova, Alya G. Mignani, Serge Caminade, Anne-Marie Majoral, Jean-Pierre Pharmaceutics Article In this work, we report the assemblage of hydrogels from phosphorus dendrimers in the presence of biocompatible additives and the study of their interactions with nucleic acids. As precursors for hydrogels, phosphorus dendrimers of generations 1–3 based on the cyclotriphosphazene core and bearing ammonium or pyridinium acetohydrazones (Girard reagents) on the periphery have been synthesized. The gelation was done by the incubation of dendrimer solutions in water or phosphate-buffered saline in the presence of biocompatible additives (glucose, glycine or polyethylene glycol) to form physical gels. Physical properties of gels have been shown to depend on the gelation conditions. Transmission electron microscopy revealed structural units and well-developed network structures of the hydrogels. The hydrogels were shown to bind nucleic acids efficiently. In summary, hydrogels of phosphorus dendrimers represent a useful tool for biomedical applications. MDPI 2018-08-06 /pmc/articles/PMC6161142/ /pubmed/30082671 http://dx.doi.org/10.3390/pharmaceutics10030120 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Apartsin, Evgeny K.
Grigoryeva, Alina E.
Malrin-Fournol, Audrey
Ryabchikova, Elena I.
Venyaminova, Alya G.
Mignani, Serge
Caminade, Anne-Marie
Majoral, Jean-Pierre
Hydrogels of Polycationic Acetohydrazone-Modified Phosphorus Dendrimers for Biomedical Applications: Gelation Studies and Nucleic Acid Loading
title Hydrogels of Polycationic Acetohydrazone-Modified Phosphorus Dendrimers for Biomedical Applications: Gelation Studies and Nucleic Acid Loading
title_full Hydrogels of Polycationic Acetohydrazone-Modified Phosphorus Dendrimers for Biomedical Applications: Gelation Studies and Nucleic Acid Loading
title_fullStr Hydrogels of Polycationic Acetohydrazone-Modified Phosphorus Dendrimers for Biomedical Applications: Gelation Studies and Nucleic Acid Loading
title_full_unstemmed Hydrogels of Polycationic Acetohydrazone-Modified Phosphorus Dendrimers for Biomedical Applications: Gelation Studies and Nucleic Acid Loading
title_short Hydrogels of Polycationic Acetohydrazone-Modified Phosphorus Dendrimers for Biomedical Applications: Gelation Studies and Nucleic Acid Loading
title_sort hydrogels of polycationic acetohydrazone-modified phosphorus dendrimers for biomedical applications: gelation studies and nucleic acid loading
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161142/
https://www.ncbi.nlm.nih.gov/pubmed/30082671
http://dx.doi.org/10.3390/pharmaceutics10030120
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