Relationship Between Morning Heart Rate Variability and Creatine Kinase Response During Intensified Training in Recreational Endurance Athletes

Specific physiological responses and their relationship were analyzed in 12 recreational endurance athletes (43.8 ± 7.9 years) during a period of intensified cycling training. Heart rate (HR), HR variability (HRV), serum creatine kinase (S-CK) and haematocrit (Hct) were measured in the mornings before (PRE) and following three consecutive days of intensified training (POST 1–3). Morning HR increased during this period (PRE: 52.2 ± 6.7 bpm, POST 1: 58.8 ± 7.0 bpm, POST 2: 58.5 ± 8.1 bpm, POST 3: 57.9 ± 7.2 bpm; F(3,33) = 11.182, p < 0.001, η(p)(2) = 0.554). Parasympathetic HRV indices decreased from PRE to POST (F(3,33) ≥ 11.588, p < 0.001, η(p)(2) ≥ 0.563), no effect was found for sympathetically modulated HRV (F(3,33) = 2.287, p = 0.101, η(p)(2) = 0.203). Hct decreased (PRE: 49.9 ± 4.0%, POST 1: 46.5 ± 5.1%, POST 2: 45.5 ± 3.8%, POST 3: 43.2 ± 3.4%; F(3,33) = 11.909, p < 0.001, η(p)(2) = 0.520) and S-CK increased during the training period (PRE: 90.0 ± 32.1 U/L, POST 1: 334.7 ± 487.6 U/L, POST 2: 260.1 ± 303.4 U/L, POST 3: 225.1 ± 258.8 U/L; F(3,33) = 3.996, p = 0.017, η(p)(2) = 0.285). S-CK release was associated with HR (r = 0.453, p = 0.002, n = 44), RMSSD (r = −0.494, p = 0.001, n = 44) and HF-Power (r = −0.490, p = 0.001, n = 44). A period of intensified training was associated with haemodilution, parasympathetic withdrawal and S-CK-increase. Cardiac autonomic control at morning rest correlated with the S-CK-release; and thus, may serve as a practical mean to complementary monitor and prescribe training load in this population.