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Relative Contributions of Solubility and Mobility to the Stability of Amorphous Solid Dispersions of Poorly Soluble Drugs: A Molecular Dynamics Simulation Study

Amorphous solid dispersions are considered a promising formulation strategy for the oral delivery of poorly soluble drugs. The limiting factor for the applicability of this approach is the physical (in)stability of the amorphous phase in solid samples. Minimizing the risk of reduced shelf life for a...

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Detalles Bibliográficos
Autores principales:	Brunsteiner, Michael, Khinast, Johannes, Paudel, Amrit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161151/ https://www.ncbi.nlm.nih.gov/pubmed/30037083 http://dx.doi.org/10.3390/pharmaceutics10030101

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