Thermo-Sensitive Vesicles in Controlled Drug Delivery for Chemotherapy

Thermo-sensitive vesicles are a promising tool for triggering the release of drugs to solid tumours when used in combination with mild hyperthermia. Responsivity to temperature makes them intelligent nanodevices able to provide a site-specific chemotherapy. Following a brief introduction concerning...

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Detalles Bibliográficos
Autores principales: Mazzotta, Elisabetta, Tavano, Lorena, Muzzalupo, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161155/
https://www.ncbi.nlm.nih.gov/pubmed/30189683
http://dx.doi.org/10.3390/pharmaceutics10030150
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author Mazzotta, Elisabetta
Tavano, Lorena
Muzzalupo, Rita
author_facet Mazzotta, Elisabetta
Tavano, Lorena
Muzzalupo, Rita
author_sort Mazzotta, Elisabetta
collection PubMed
description Thermo-sensitive vesicles are a promising tool for triggering the release of drugs to solid tumours when used in combination with mild hyperthermia. Responsivity to temperature makes them intelligent nanodevices able to provide a site-specific chemotherapy. Following a brief introduction concerning hyperthermia and its advantageous combination with vesicular systems, recent investigations on thermo-sensitive vesicles useful for controlled drug delivery in cancer treatment are reported in this review. In particular, the influence of bilayer composition on the in vitro and in vivo behaviour of thermo-sensitive formulations currently under investigation have been extensively explored.
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spelling pubmed-61611552018-10-01 Thermo-Sensitive Vesicles in Controlled Drug Delivery for Chemotherapy Mazzotta, Elisabetta Tavano, Lorena Muzzalupo, Rita Pharmaceutics Review Thermo-sensitive vesicles are a promising tool for triggering the release of drugs to solid tumours when used in combination with mild hyperthermia. Responsivity to temperature makes them intelligent nanodevices able to provide a site-specific chemotherapy. Following a brief introduction concerning hyperthermia and its advantageous combination with vesicular systems, recent investigations on thermo-sensitive vesicles useful for controlled drug delivery in cancer treatment are reported in this review. In particular, the influence of bilayer composition on the in vitro and in vivo behaviour of thermo-sensitive formulations currently under investigation have been extensively explored. MDPI 2018-09-05 /pmc/articles/PMC6161155/ /pubmed/30189683 http://dx.doi.org/10.3390/pharmaceutics10030150 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mazzotta, Elisabetta
Tavano, Lorena
Muzzalupo, Rita
Thermo-Sensitive Vesicles in Controlled Drug Delivery for Chemotherapy
title Thermo-Sensitive Vesicles in Controlled Drug Delivery for Chemotherapy
title_full Thermo-Sensitive Vesicles in Controlled Drug Delivery for Chemotherapy
title_fullStr Thermo-Sensitive Vesicles in Controlled Drug Delivery for Chemotherapy
title_full_unstemmed Thermo-Sensitive Vesicles in Controlled Drug Delivery for Chemotherapy
title_short Thermo-Sensitive Vesicles in Controlled Drug Delivery for Chemotherapy
title_sort thermo-sensitive vesicles in controlled drug delivery for chemotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161155/
https://www.ncbi.nlm.nih.gov/pubmed/30189683
http://dx.doi.org/10.3390/pharmaceutics10030150
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