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In Vitro Activity of Newer and Conventional Antimicrobial Agents, Including Fosfomycin and Colistin, against Selected Gram-Negative Bacilli in Kuwait
Limited data are available on susceptibilities of these organisms to some of the recently made accessible antimicrobial agents. The in vitro activities of newer antibiotics, such as, ceftolozane/tazobactam (C/T) and ceftazidime/avibactam (CZA) along with some “older” antibiotics, for example fosfomy...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161270/ https://www.ncbi.nlm.nih.gov/pubmed/30227619 http://dx.doi.org/10.3390/pathogens7030075 |
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author | Alfouzan, Wadha Dhar, Rita Nicolau, David P. |
author_facet | Alfouzan, Wadha Dhar, Rita Nicolau, David P. |
author_sort | Alfouzan, Wadha |
collection | PubMed |
description | Limited data are available on susceptibilities of these organisms to some of the recently made accessible antimicrobial agents. The in vitro activities of newer antibiotics, such as, ceftolozane/tazobactam (C/T) and ceftazidime/avibactam (CZA) along with some “older” antibiotics, for example fosfomycin (FOS) and colistin (CL) were determined against selected strains (resistant to [Formula: see text] antimicrobial agents) of Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Minimum inhibitory concentrations (MIC) were determined by Clinical and Laboratory Standards Institute microbroth dilution. 133 isolates: 46 E. coli, 39 K. pneumoniae, and 48 P. aeruginosa were tested. Results showed that E. coli isolates with MIC(50/90), 0.5/1 [Formula: see text] for CL; 4/32 [Formula: see text] for FOS; 0.25/32 [Formula: see text] for C/T; 0.25/8 [Formula: see text] for CZA, exhibited susceptibility rates of 95.7%, 97.8%, 76.1%, and 89.1%, respectively. On the other hand, K. pneumoniae strains with MIC(50/90), 0.5/1 [Formula: see text] for CL; 256/512 [Formula: see text] for FOS; 2/128 [Formula: see text] for C/T; 0.5/128 [Formula: see text] for CZA showed susceptibility rates of 92.3%, 7.7%, 51.3%, and 64.1%, respectively. P. aeruginosa isolates with MIC(50/90), 1/1 [Formula: see text] for CL; 128/128 [Formula: see text] for C/T; 32/64 [Formula: see text] for CZA presented susceptibility rates of 97.9%, 33.3%, and 39.6%, respectively. Higher MICs were demonstrated against most of the antibiotics. However, CL retained efficacy at low MICs against most of the isolates tested. |
format | Online Article Text |
id | pubmed-6161270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61612702018-10-01 In Vitro Activity of Newer and Conventional Antimicrobial Agents, Including Fosfomycin and Colistin, against Selected Gram-Negative Bacilli in Kuwait Alfouzan, Wadha Dhar, Rita Nicolau, David P. Pathogens Article Limited data are available on susceptibilities of these organisms to some of the recently made accessible antimicrobial agents. The in vitro activities of newer antibiotics, such as, ceftolozane/tazobactam (C/T) and ceftazidime/avibactam (CZA) along with some “older” antibiotics, for example fosfomycin (FOS) and colistin (CL) were determined against selected strains (resistant to [Formula: see text] antimicrobial agents) of Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Minimum inhibitory concentrations (MIC) were determined by Clinical and Laboratory Standards Institute microbroth dilution. 133 isolates: 46 E. coli, 39 K. pneumoniae, and 48 P. aeruginosa were tested. Results showed that E. coli isolates with MIC(50/90), 0.5/1 [Formula: see text] for CL; 4/32 [Formula: see text] for FOS; 0.25/32 [Formula: see text] for C/T; 0.25/8 [Formula: see text] for CZA, exhibited susceptibility rates of 95.7%, 97.8%, 76.1%, and 89.1%, respectively. On the other hand, K. pneumoniae strains with MIC(50/90), 0.5/1 [Formula: see text] for CL; 256/512 [Formula: see text] for FOS; 2/128 [Formula: see text] for C/T; 0.5/128 [Formula: see text] for CZA showed susceptibility rates of 92.3%, 7.7%, 51.3%, and 64.1%, respectively. P. aeruginosa isolates with MIC(50/90), 1/1 [Formula: see text] for CL; 128/128 [Formula: see text] for C/T; 32/64 [Formula: see text] for CZA presented susceptibility rates of 97.9%, 33.3%, and 39.6%, respectively. Higher MICs were demonstrated against most of the antibiotics. However, CL retained efficacy at low MICs against most of the isolates tested. MDPI 2018-09-17 /pmc/articles/PMC6161270/ /pubmed/30227619 http://dx.doi.org/10.3390/pathogens7030075 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alfouzan, Wadha Dhar, Rita Nicolau, David P. In Vitro Activity of Newer and Conventional Antimicrobial Agents, Including Fosfomycin and Colistin, against Selected Gram-Negative Bacilli in Kuwait |
title | In Vitro Activity of Newer and Conventional Antimicrobial Agents, Including Fosfomycin and Colistin, against Selected Gram-Negative Bacilli in Kuwait |
title_full | In Vitro Activity of Newer and Conventional Antimicrobial Agents, Including Fosfomycin and Colistin, against Selected Gram-Negative Bacilli in Kuwait |
title_fullStr | In Vitro Activity of Newer and Conventional Antimicrobial Agents, Including Fosfomycin and Colistin, against Selected Gram-Negative Bacilli in Kuwait |
title_full_unstemmed | In Vitro Activity of Newer and Conventional Antimicrobial Agents, Including Fosfomycin and Colistin, against Selected Gram-Negative Bacilli in Kuwait |
title_short | In Vitro Activity of Newer and Conventional Antimicrobial Agents, Including Fosfomycin and Colistin, against Selected Gram-Negative Bacilli in Kuwait |
title_sort | in vitro activity of newer and conventional antimicrobial agents, including fosfomycin and colistin, against selected gram-negative bacilli in kuwait |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161270/ https://www.ncbi.nlm.nih.gov/pubmed/30227619 http://dx.doi.org/10.3390/pathogens7030075 |
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