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Miliary Tuberculosis Presenting with Hyponatremia and ARDS in an 82-Year-Old Immunocompetent Female

An immunocompetent 82-year-old female was admitted to our hospital due to fever without clear origin and hyponatremia. In the following days, an acute and bilateral pulmonary infiltrate appeared with a progressive worsening in respiratory function. Chest x-ray and CT (Computed tomography) showed bil...

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Autores principales: Herreros, Benjamín, Plaza, Isabel, García, Rebeca, Chichón, Marta, Guerrero, Carmen, Pintor, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161313/
https://www.ncbi.nlm.nih.gov/pubmed/30189694
http://dx.doi.org/10.3390/pathogens7030072
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author Herreros, Benjamín
Plaza, Isabel
García, Rebeca
Chichón, Marta
Guerrero, Carmen
Pintor, Emilio
author_facet Herreros, Benjamín
Plaza, Isabel
García, Rebeca
Chichón, Marta
Guerrero, Carmen
Pintor, Emilio
author_sort Herreros, Benjamín
collection PubMed
description An immunocompetent 82-year-old female was admitted to our hospital due to fever without clear origin and hyponatremia. In the following days, an acute and bilateral pulmonary infiltrate appeared with a progressive worsening in respiratory function. Chest x-ray and CT (Computed tomography) showed bilateral reticulonodular infiltrates. Bronchoscopic aspiration and bronchoalveolar lavage (BAL), and transbronchial lung biopsy (TBBX) studies did not reveal microbiological and histopathological diagnosis. Broad-spectrum antibiotics were non-effective, and the patient died due to respiratory failure. Necropsy study revealed a miliary tuberculosis affecting lungs, liver, bone marrow, spleen, kidney, arteries, pancreas, and adrenal glands. Some weeks after the patient´s death, mycobacterial cultures from sputum, BAL and TBBX samples were positive for Mycobacterium tuberculosis.
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spelling pubmed-61613132018-10-01 Miliary Tuberculosis Presenting with Hyponatremia and ARDS in an 82-Year-Old Immunocompetent Female Herreros, Benjamín Plaza, Isabel García, Rebeca Chichón, Marta Guerrero, Carmen Pintor, Emilio Pathogens Case Report An immunocompetent 82-year-old female was admitted to our hospital due to fever without clear origin and hyponatremia. In the following days, an acute and bilateral pulmonary infiltrate appeared with a progressive worsening in respiratory function. Chest x-ray and CT (Computed tomography) showed bilateral reticulonodular infiltrates. Bronchoscopic aspiration and bronchoalveolar lavage (BAL), and transbronchial lung biopsy (TBBX) studies did not reveal microbiological and histopathological diagnosis. Broad-spectrum antibiotics were non-effective, and the patient died due to respiratory failure. Necropsy study revealed a miliary tuberculosis affecting lungs, liver, bone marrow, spleen, kidney, arteries, pancreas, and adrenal glands. Some weeks after the patient´s death, mycobacterial cultures from sputum, BAL and TBBX samples were positive for Mycobacterium tuberculosis. MDPI 2018-09-05 /pmc/articles/PMC6161313/ /pubmed/30189694 http://dx.doi.org/10.3390/pathogens7030072 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Herreros, Benjamín
Plaza, Isabel
García, Rebeca
Chichón, Marta
Guerrero, Carmen
Pintor, Emilio
Miliary Tuberculosis Presenting with Hyponatremia and ARDS in an 82-Year-Old Immunocompetent Female
title Miliary Tuberculosis Presenting with Hyponatremia and ARDS in an 82-Year-Old Immunocompetent Female
title_full Miliary Tuberculosis Presenting with Hyponatremia and ARDS in an 82-Year-Old Immunocompetent Female
title_fullStr Miliary Tuberculosis Presenting with Hyponatremia and ARDS in an 82-Year-Old Immunocompetent Female
title_full_unstemmed Miliary Tuberculosis Presenting with Hyponatremia and ARDS in an 82-Year-Old Immunocompetent Female
title_short Miliary Tuberculosis Presenting with Hyponatremia and ARDS in an 82-Year-Old Immunocompetent Female
title_sort miliary tuberculosis presenting with hyponatremia and ards in an 82-year-old immunocompetent female
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161313/
https://www.ncbi.nlm.nih.gov/pubmed/30189694
http://dx.doi.org/10.3390/pathogens7030072
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