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Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample

BACKGROUND: Neuropathic-like knee pain (NKP) is often reported in individuals with knee pain (KP), but the contribution of specific central and peripheral risk factors to NKP has not been studied previously. The aims of the present study were to determine the prevalence of NKP in a community-derived...

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Autores principales: Fernandes, Gwen Sascha, Valdes, Ana Marie, Walsh, David Andrew, Zhang, Weiya, Doherty, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161431/
https://www.ncbi.nlm.nih.gov/pubmed/30261907
http://dx.doi.org/10.1186/s13075-018-1717-6
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author Fernandes, Gwen Sascha
Valdes, Ana Marie
Walsh, David Andrew
Zhang, Weiya
Doherty, Michael
author_facet Fernandes, Gwen Sascha
Valdes, Ana Marie
Walsh, David Andrew
Zhang, Weiya
Doherty, Michael
author_sort Fernandes, Gwen Sascha
collection PubMed
description BACKGROUND: Neuropathic-like knee pain (NKP) is often reported in individuals with knee pain (KP), but the contribution of specific central and peripheral risk factors to NKP has not been studied previously. The aims of the present study were to determine the prevalence of NKP in a community-derived sample with KP and to identify risk factors associated with NKP. METHODS: A cross-sectional study was undertaken (n = 9506) in the East Midlands community among responders (aged 40+ years) to a postal questionnaire. Questions included KP severity (numerical rating scale) and type (neuropathic versus nociceptive) using the modified painDETECT questionnaire, as well as age, body mass index (BMI), significant knee injury, widespread pain, pain catastrophising and fatigue. Multinomial regression analysis was used to determine ORs and 95% CIs. Risk factors were categorised into central and peripheral, and proportional risk contribution (PRC) and 95% CI were estimated using ROC. RESULTS: KP was reported in 28.2% of responders, of whom 13.65% had NKP (i.e., 3.9% of the total population). Women reported more NKP. After adjustment for age, gender, BMI and pain severity, definite NKP showed associations (aOR, 95% CI) with fibromyalgia (4.07, 2.49–6.66), widespread pain (1.93, 1.46–2.53), nodal osteoarthritis (1.80, 1.28–2.53), injury (1.50, 1.12–2.00), pain catastrophising (5.37, 2.93–9.84) and fatigue (5.37, 3.08–9.35) compared with non-NKP participants. Although only central risk factors contributed to NKP (PRC 8%, 95% CI 2.5–12.5 for central vs. PRC 3%, 95% CI −0.25 to 7.5 for peripheral), both central and peripheral risk factors contributed equally to non-NKP (PRC 10%, 95% CI 5–20 for both). CONCLUSIONS: NKP appears to be driven largely by central risk factors and may require different prevention/treatment strategies. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02098070. Registered on 27 March 2014.
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spelling pubmed-61614312018-10-01 Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample Fernandes, Gwen Sascha Valdes, Ana Marie Walsh, David Andrew Zhang, Weiya Doherty, Michael Arthritis Res Ther Research Article BACKGROUND: Neuropathic-like knee pain (NKP) is often reported in individuals with knee pain (KP), but the contribution of specific central and peripheral risk factors to NKP has not been studied previously. The aims of the present study were to determine the prevalence of NKP in a community-derived sample with KP and to identify risk factors associated with NKP. METHODS: A cross-sectional study was undertaken (n = 9506) in the East Midlands community among responders (aged 40+ years) to a postal questionnaire. Questions included KP severity (numerical rating scale) and type (neuropathic versus nociceptive) using the modified painDETECT questionnaire, as well as age, body mass index (BMI), significant knee injury, widespread pain, pain catastrophising and fatigue. Multinomial regression analysis was used to determine ORs and 95% CIs. Risk factors were categorised into central and peripheral, and proportional risk contribution (PRC) and 95% CI were estimated using ROC. RESULTS: KP was reported in 28.2% of responders, of whom 13.65% had NKP (i.e., 3.9% of the total population). Women reported more NKP. After adjustment for age, gender, BMI and pain severity, definite NKP showed associations (aOR, 95% CI) with fibromyalgia (4.07, 2.49–6.66), widespread pain (1.93, 1.46–2.53), nodal osteoarthritis (1.80, 1.28–2.53), injury (1.50, 1.12–2.00), pain catastrophising (5.37, 2.93–9.84) and fatigue (5.37, 3.08–9.35) compared with non-NKP participants. Although only central risk factors contributed to NKP (PRC 8%, 95% CI 2.5–12.5 for central vs. PRC 3%, 95% CI −0.25 to 7.5 for peripheral), both central and peripheral risk factors contributed equally to non-NKP (PRC 10%, 95% CI 5–20 for both). CONCLUSIONS: NKP appears to be driven largely by central risk factors and may require different prevention/treatment strategies. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02098070. Registered on 27 March 2014. BioMed Central 2018-09-27 2018 /pmc/articles/PMC6161431/ /pubmed/30261907 http://dx.doi.org/10.1186/s13075-018-1717-6 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Fernandes, Gwen Sascha
Valdes, Ana Marie
Walsh, David Andrew
Zhang, Weiya
Doherty, Michael
Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample
title Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample
title_full Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample
title_fullStr Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample
title_full_unstemmed Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample
title_short Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample
title_sort neuropathic-like knee pain and associated risk factors: a cross-sectional study in a uk community sample
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161431/
https://www.ncbi.nlm.nih.gov/pubmed/30261907
http://dx.doi.org/10.1186/s13075-018-1717-6
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