Boosting mTOR-dependent autophagy via upstream TLR4-MyD88-MAPK signalling and downstream NF-κB pathway quenches intestinal inflammation and oxidative stress injury

BACKGROUND AND AIMS: Defective autophagy has been proposed as an important event in a growing number of autoimmune and inflammatory diseases such as rheumatoid arthritis and lupus. However, the precise role of mechanistic target of rapamycin (mTOR)-dependent autophagy and its underlying regulatory m...

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Detalles Bibliográficos
Autores principales: Zhou, Mingxia, Xu, Weimin, Wang, Jiazheng, Yan, Junkai, Shi, Yingying, Zhang, Cong, Ge, Wensong, Wu, Jin, Du, Peng, Chen, Yingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161481/
https://www.ncbi.nlm.nih.gov/pubmed/30170968
http://dx.doi.org/10.1016/j.ebiom.2018.08.035

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