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Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study

There is an alarming tide of cardiovascular and metabolic disease (CMD) sweeping across Africa. This may be a result of an increasingly urbanized lifestyle characterized by the growing consumption of processed and calorie-dense food, combined with physical inactivity and more sedentary behaviour. Wh...

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Autores principales: Ali, Stuart A., Soo, Cassandra, Agongo, Godfred, Alberts, Marianne, Amenga-Etego, Lucas, Boua, Romuald P., Choudhury, Ananyo, Crowther, Nigel J., Depuur, Cornelius, Gómez-Olivé, F. Xavier, Guiraud, Issa, Haregu, Tilahun N., Hazelhurst, Scott, Kahn, Kathleen, Khayeka-Wandabwa, Christopher, Kyobutungi, Catherine, Lombard, Zané, Mashinya, Felistas, Micklesfield, Lisa, Mohamed, Shukri F., Mukomana, Freedom, Nakanabo-Diallo, Seydou, Natama, Hamtandi M., Ngomi, Nicholas, Nonterah, Engelbert A., Norris, Shane A., Oduro, Abraham R., Somé, Athanase M., Sorgho, Hermann, Tindana, Paulina, Tinto, Halidou, Tollman, Stephen, Twine, Rhian, Wade, Alisha, Sankoh, Osman, Ramsay, Michèle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161608/
https://www.ncbi.nlm.nih.gov/pubmed/30259792
http://dx.doi.org/10.1080/16549716.2018.1507133
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author Ali, Stuart A.
Soo, Cassandra
Agongo, Godfred
Alberts, Marianne
Amenga-Etego, Lucas
Boua, Romuald P.
Choudhury, Ananyo
Crowther, Nigel J.
Depuur, Cornelius
Gómez-Olivé, F. Xavier
Guiraud, Issa
Haregu, Tilahun N.
Hazelhurst, Scott
Kahn, Kathleen
Khayeka-Wandabwa, Christopher
Kyobutungi, Catherine
Lombard, Zané
Mashinya, Felistas
Micklesfield, Lisa
Mohamed, Shukri F.
Mukomana, Freedom
Nakanabo-Diallo, Seydou
Natama, Hamtandi M.
Ngomi, Nicholas
Nonterah, Engelbert A.
Norris, Shane A.
Oduro, Abraham R.
Somé, Athanase M.
Sorgho, Hermann
Tindana, Paulina
Tinto, Halidou
Tollman, Stephen
Twine, Rhian
Wade, Alisha
Sankoh, Osman
Ramsay, Michèle
author_facet Ali, Stuart A.
Soo, Cassandra
Agongo, Godfred
Alberts, Marianne
Amenga-Etego, Lucas
Boua, Romuald P.
Choudhury, Ananyo
Crowther, Nigel J.
Depuur, Cornelius
Gómez-Olivé, F. Xavier
Guiraud, Issa
Haregu, Tilahun N.
Hazelhurst, Scott
Kahn, Kathleen
Khayeka-Wandabwa, Christopher
Kyobutungi, Catherine
Lombard, Zané
Mashinya, Felistas
Micklesfield, Lisa
Mohamed, Shukri F.
Mukomana, Freedom
Nakanabo-Diallo, Seydou
Natama, Hamtandi M.
Ngomi, Nicholas
Nonterah, Engelbert A.
Norris, Shane A.
Oduro, Abraham R.
Somé, Athanase M.
Sorgho, Hermann
Tindana, Paulina
Tinto, Halidou
Tollman, Stephen
Twine, Rhian
Wade, Alisha
Sankoh, Osman
Ramsay, Michèle
author_sort Ali, Stuart A.
collection PubMed
description There is an alarming tide of cardiovascular and metabolic disease (CMD) sweeping across Africa. This may be a result of an increasingly urbanized lifestyle characterized by the growing consumption of processed and calorie-dense food, combined with physical inactivity and more sedentary behaviour. While the link between lifestyle and public health has been extensively studied in Caucasian and African American populations, few studies have been conducted in Africa. This paper describes the detailed methods for Phase 1 of the AWI-Gen study that were used to capture phenotype data and assess the associated risk factors and end points for CMD in persons over the age of 40 years in sub-Saharan Africa (SSA). We developed a population-based cross-sectional study of disease burden and phenotype in Africans, across six centres in SSA. These centres are in West Africa (Nanoro, Burkina Faso, and Navrongo, Ghana), in East Africa (Nairobi, Kenya) and in South Africa (Agincourt, Dikgale and Soweto). A total of 10,702 individuals between the ages of 40 and 60 years were recruited into the study across the six centres, plus an additional 1021 participants over the age of 60 years from the Agincourt centre. We collected socio-demographic, anthropometric, medical history, diet, physical activity, fat distribution and alcohol/tobacco consumption data from participants. Blood samples were collected for disease-related biomarker assays, and genomic DNA extraction for genome-wide association studies. Urine samples were collected to assess kidney function. The study provides base-line data for the development of a series of cohorts with a second wave of data collection in Phase 2 of the study. These data will provide valuable insights into the genetic and environmental influences on CMD on the African continent.
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spelling pubmed-61616082018-10-01 Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study Ali, Stuart A. Soo, Cassandra Agongo, Godfred Alberts, Marianne Amenga-Etego, Lucas Boua, Romuald P. Choudhury, Ananyo Crowther, Nigel J. Depuur, Cornelius Gómez-Olivé, F. Xavier Guiraud, Issa Haregu, Tilahun N. Hazelhurst, Scott Kahn, Kathleen Khayeka-Wandabwa, Christopher Kyobutungi, Catherine Lombard, Zané Mashinya, Felistas Micklesfield, Lisa Mohamed, Shukri F. Mukomana, Freedom Nakanabo-Diallo, Seydou Natama, Hamtandi M. Ngomi, Nicholas Nonterah, Engelbert A. Norris, Shane A. Oduro, Abraham R. Somé, Athanase M. Sorgho, Hermann Tindana, Paulina Tinto, Halidou Tollman, Stephen Twine, Rhian Wade, Alisha Sankoh, Osman Ramsay, Michèle Glob Health Action Study Design Article There is an alarming tide of cardiovascular and metabolic disease (CMD) sweeping across Africa. This may be a result of an increasingly urbanized lifestyle characterized by the growing consumption of processed and calorie-dense food, combined with physical inactivity and more sedentary behaviour. While the link between lifestyle and public health has been extensively studied in Caucasian and African American populations, few studies have been conducted in Africa. This paper describes the detailed methods for Phase 1 of the AWI-Gen study that were used to capture phenotype data and assess the associated risk factors and end points for CMD in persons over the age of 40 years in sub-Saharan Africa (SSA). We developed a population-based cross-sectional study of disease burden and phenotype in Africans, across six centres in SSA. These centres are in West Africa (Nanoro, Burkina Faso, and Navrongo, Ghana), in East Africa (Nairobi, Kenya) and in South Africa (Agincourt, Dikgale and Soweto). A total of 10,702 individuals between the ages of 40 and 60 years were recruited into the study across the six centres, plus an additional 1021 participants over the age of 60 years from the Agincourt centre. We collected socio-demographic, anthropometric, medical history, diet, physical activity, fat distribution and alcohol/tobacco consumption data from participants. Blood samples were collected for disease-related biomarker assays, and genomic DNA extraction for genome-wide association studies. Urine samples were collected to assess kidney function. The study provides base-line data for the development of a series of cohorts with a second wave of data collection in Phase 2 of the study. These data will provide valuable insights into the genetic and environmental influences on CMD on the African continent. Taylor & Francis 2018-09-27 /pmc/articles/PMC6161608/ /pubmed/30259792 http://dx.doi.org/10.1080/16549716.2018.1507133 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Study Design Article
Ali, Stuart A.
Soo, Cassandra
Agongo, Godfred
Alberts, Marianne
Amenga-Etego, Lucas
Boua, Romuald P.
Choudhury, Ananyo
Crowther, Nigel J.
Depuur, Cornelius
Gómez-Olivé, F. Xavier
Guiraud, Issa
Haregu, Tilahun N.
Hazelhurst, Scott
Kahn, Kathleen
Khayeka-Wandabwa, Christopher
Kyobutungi, Catherine
Lombard, Zané
Mashinya, Felistas
Micklesfield, Lisa
Mohamed, Shukri F.
Mukomana, Freedom
Nakanabo-Diallo, Seydou
Natama, Hamtandi M.
Ngomi, Nicholas
Nonterah, Engelbert A.
Norris, Shane A.
Oduro, Abraham R.
Somé, Athanase M.
Sorgho, Hermann
Tindana, Paulina
Tinto, Halidou
Tollman, Stephen
Twine, Rhian
Wade, Alisha
Sankoh, Osman
Ramsay, Michèle
Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study
title Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study
title_full Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study
title_fullStr Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study
title_full_unstemmed Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study
title_short Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study
title_sort genomic and environmental risk factors for cardiometabolic diseases in africa: methods used for phase 1 of the awi-gen population cross-sectional study
topic Study Design Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161608/
https://www.ncbi.nlm.nih.gov/pubmed/30259792
http://dx.doi.org/10.1080/16549716.2018.1507133
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