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Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age

Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the typical subjective effects of marijuana. Objectives: The aim of the present review is to describe the main advances in the development of the experimental and clinical use of cann...

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Autores principales: Crippa, José A., Guimarães, Francisco S., Campos, Alline C., Zuardi, Antonio W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161644/
https://www.ncbi.nlm.nih.gov/pubmed/30298064
http://dx.doi.org/10.3389/fimmu.2018.02009
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author Crippa, José A.
Guimarães, Francisco S.
Campos, Alline C.
Zuardi, Antonio W.
author_facet Crippa, José A.
Guimarães, Francisco S.
Campos, Alline C.
Zuardi, Antonio W.
author_sort Crippa, José A.
collection PubMed
description Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the typical subjective effects of marijuana. Objectives: The aim of the present review is to describe the main advances in the development of the experimental and clinical use of cannabidiol CBD in neuropsychiatry. Methods: A non-systematic search was performed for studies dealing with therapeutic applications of CBD, especially performed by Brazilian researchers. Results: CBD was shown to have anxiolytic, antipsychotic and neuroprotective properties. In addition, basic and clinical investigations on the effects of CBD have been carried out in the context of many other health conditions, including its potential use in epilepsy, substance abuse and dependence, schizophrenia, social phobia, post-traumatic stress, depression, bipolar disorder, sleep disorders, and Parkinson. Discussion: CBD is an useful and promising molecule that may help patients with a number of clinical conditions. Controlled clinical trials with different neuropsychiatric populations that are currently under investigation should bring important answers in the near future and support the translation of research findings to clinical settings.
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spelling pubmed-61616442018-10-08 Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age Crippa, José A. Guimarães, Francisco S. Campos, Alline C. Zuardi, Antonio W. Front Immunol Immunology Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the typical subjective effects of marijuana. Objectives: The aim of the present review is to describe the main advances in the development of the experimental and clinical use of cannabidiol CBD in neuropsychiatry. Methods: A non-systematic search was performed for studies dealing with therapeutic applications of CBD, especially performed by Brazilian researchers. Results: CBD was shown to have anxiolytic, antipsychotic and neuroprotective properties. In addition, basic and clinical investigations on the effects of CBD have been carried out in the context of many other health conditions, including its potential use in epilepsy, substance abuse and dependence, schizophrenia, social phobia, post-traumatic stress, depression, bipolar disorder, sleep disorders, and Parkinson. Discussion: CBD is an useful and promising molecule that may help patients with a number of clinical conditions. Controlled clinical trials with different neuropsychiatric populations that are currently under investigation should bring important answers in the near future and support the translation of research findings to clinical settings. Frontiers Media S.A. 2018-09-21 /pmc/articles/PMC6161644/ /pubmed/30298064 http://dx.doi.org/10.3389/fimmu.2018.02009 Text en Copyright © 2018 Crippa, Guimarães, Campos and Zuardi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Crippa, José A.
Guimarães, Francisco S.
Campos, Alline C.
Zuardi, Antonio W.
Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age
title Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age
title_full Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age
title_fullStr Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age
title_full_unstemmed Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age
title_short Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age
title_sort translational investigation of the therapeutic potential of cannabidiol (cbd): toward a new age
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161644/
https://www.ncbi.nlm.nih.gov/pubmed/30298064
http://dx.doi.org/10.3389/fimmu.2018.02009
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