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Cereblon modulator iberdomide induces degradation of the transcription factors Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus

OBJECTIVES: IKZF1 and IKZF3 (encoding transcription factors Ikaros and Aiolos) are susceptibility loci for systemic lupus erythematosus (SLE). The pharmacology of iberdomide (CC-220), a cereblon (CRBN) modulator targeting Ikaros and Aiolos, was studied in SLE patient cells and in a phase 1 healthy v...

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Detalles Bibliográficos
Autores principales:	Schafer, Peter H, Ye, Ying, Wu, Lei, Kosek, Jolanta, Ringheim, Garth, Yang, Zhihong, Liu, Liangang, Thomas, Michael, Palmisano, Maria, Chopra, Rajesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2018
Materias:	Basic and Translational Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161670/ https://www.ncbi.nlm.nih.gov/pubmed/29945920 http://dx.doi.org/10.1136/annrheumdis-2017-212916

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