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A Fatal Bacteremia Caused by Hypermucousviscous KPC-2 Producing Extensively Drug-Resistant K64-ST11 Klebsiella pneumoniae in Brazil

We report a fatal bacteremia caused by Klebsiella pneumoniae in a 60–70-year-old patient from Brazil. The genomic analysis of three isolates (from blood culture, nasal and anal swabs) showed that the bacteremia was caused by a KPC-2 producing extensively drug-resistant K64-ST11 hypermucousviscous K....

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Autores principales: de Campos, Tatiana Amabile, Gonçalves, Laura Fernandes, Magalhães, Kelly Grace, de Paulo Martins, Vicente, Pappas Júnior, Georgios Joannis, Peirano, Gisele, Pitout, Johann D. D., Gonçalves, Guilherme Bartolomeu, Furlan, João Pedro Rueda, Stehling, Eliana Guedes, Pitondo-Silva, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161680/
https://www.ncbi.nlm.nih.gov/pubmed/30298131
http://dx.doi.org/10.3389/fmed.2018.00265
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author de Campos, Tatiana Amabile
Gonçalves, Laura Fernandes
Magalhães, Kelly Grace
de Paulo Martins, Vicente
Pappas Júnior, Georgios Joannis
Peirano, Gisele
Pitout, Johann D. D.
Gonçalves, Guilherme Bartolomeu
Furlan, João Pedro Rueda
Stehling, Eliana Guedes
Pitondo-Silva, André
author_facet de Campos, Tatiana Amabile
Gonçalves, Laura Fernandes
Magalhães, Kelly Grace
de Paulo Martins, Vicente
Pappas Júnior, Georgios Joannis
Peirano, Gisele
Pitout, Johann D. D.
Gonçalves, Guilherme Bartolomeu
Furlan, João Pedro Rueda
Stehling, Eliana Guedes
Pitondo-Silva, André
author_sort de Campos, Tatiana Amabile
collection PubMed
description We report a fatal bacteremia caused by Klebsiella pneumoniae in a 60–70-year-old patient from Brazil. The genomic analysis of three isolates (from blood culture, nasal and anal swabs) showed that the bacteremia was caused by a KPC-2 producing extensively drug-resistant K64-ST11 hypermucousviscous K. pneumoniae (hmKP) harboring several virulence and antimicrobial resistance genes. Although the isolates did not present virulence markers associated with hypervirulent K. pneumoniae (hvKP), they showed invasion and toxicity to epithelial Hep-2 cells; resistance to cell microbicidal mechanisms; and blood and human serum survival, evidencing their pathogenic potential. This study highlights the risk of infection caused by hmKp strains not characterized as hvKP as well as the clinical implications and difficulty of treatment, especially in elderly or immunocompromised patients.
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spelling pubmed-61616802018-10-08 A Fatal Bacteremia Caused by Hypermucousviscous KPC-2 Producing Extensively Drug-Resistant K64-ST11 Klebsiella pneumoniae in Brazil de Campos, Tatiana Amabile Gonçalves, Laura Fernandes Magalhães, Kelly Grace de Paulo Martins, Vicente Pappas Júnior, Georgios Joannis Peirano, Gisele Pitout, Johann D. D. Gonçalves, Guilherme Bartolomeu Furlan, João Pedro Rueda Stehling, Eliana Guedes Pitondo-Silva, André Front Med (Lausanne) Medicine We report a fatal bacteremia caused by Klebsiella pneumoniae in a 60–70-year-old patient from Brazil. The genomic analysis of three isolates (from blood culture, nasal and anal swabs) showed that the bacteremia was caused by a KPC-2 producing extensively drug-resistant K64-ST11 hypermucousviscous K. pneumoniae (hmKP) harboring several virulence and antimicrobial resistance genes. Although the isolates did not present virulence markers associated with hypervirulent K. pneumoniae (hvKP), they showed invasion and toxicity to epithelial Hep-2 cells; resistance to cell microbicidal mechanisms; and blood and human serum survival, evidencing their pathogenic potential. This study highlights the risk of infection caused by hmKp strains not characterized as hvKP as well as the clinical implications and difficulty of treatment, especially in elderly or immunocompromised patients. Frontiers Media S.A. 2018-09-21 /pmc/articles/PMC6161680/ /pubmed/30298131 http://dx.doi.org/10.3389/fmed.2018.00265 Text en Copyright © 2018 de Campos, Gonçalves, Magalhães, de Paulo Martins, Pappas Júnior, Peirano, Pitout, Gonçalves, Furlan, Stehling and Pitondo-Silva. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
de Campos, Tatiana Amabile
Gonçalves, Laura Fernandes
Magalhães, Kelly Grace
de Paulo Martins, Vicente
Pappas Júnior, Georgios Joannis
Peirano, Gisele
Pitout, Johann D. D.
Gonçalves, Guilherme Bartolomeu
Furlan, João Pedro Rueda
Stehling, Eliana Guedes
Pitondo-Silva, André
A Fatal Bacteremia Caused by Hypermucousviscous KPC-2 Producing Extensively Drug-Resistant K64-ST11 Klebsiella pneumoniae in Brazil
title A Fatal Bacteremia Caused by Hypermucousviscous KPC-2 Producing Extensively Drug-Resistant K64-ST11 Klebsiella pneumoniae in Brazil
title_full A Fatal Bacteremia Caused by Hypermucousviscous KPC-2 Producing Extensively Drug-Resistant K64-ST11 Klebsiella pneumoniae in Brazil
title_fullStr A Fatal Bacteremia Caused by Hypermucousviscous KPC-2 Producing Extensively Drug-Resistant K64-ST11 Klebsiella pneumoniae in Brazil
title_full_unstemmed A Fatal Bacteremia Caused by Hypermucousviscous KPC-2 Producing Extensively Drug-Resistant K64-ST11 Klebsiella pneumoniae in Brazil
title_short A Fatal Bacteremia Caused by Hypermucousviscous KPC-2 Producing Extensively Drug-Resistant K64-ST11 Klebsiella pneumoniae in Brazil
title_sort fatal bacteremia caused by hypermucousviscous kpc-2 producing extensively drug-resistant k64-st11 klebsiella pneumoniae in brazil
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161680/
https://www.ncbi.nlm.nih.gov/pubmed/30298131
http://dx.doi.org/10.3389/fmed.2018.00265
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