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Computed tomography scan efficacy in staging gastric linitis plastica lesion: a retrospective multicentric French study

BACKGROUND: Computed tomography (CT) scan is a key imaging technique in the staging of gastric adenocarcinoma and therapeutic management of patients. The aim of this study was to evaluate the performance of CT scan in the staging of parietal and metastatic invasion in gastric linitis plastica group....

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Autores principales: Morgant, Stéphanie, Artru, Pascal, Oudjit, Ammar, Lourenco, Nelson, Pasquer, Arnaud, Walter, Thomas, Gornet, Jean-Marc, Rouquette, Alexandre, Lledo, Gérard, Brezault, Catherine, Coriat, Romain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161744/
https://www.ncbi.nlm.nih.gov/pubmed/30288113
http://dx.doi.org/10.2147/CMAR.S163141
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author Morgant, Stéphanie
Artru, Pascal
Oudjit, Ammar
Lourenco, Nelson
Pasquer, Arnaud
Walter, Thomas
Gornet, Jean-Marc
Rouquette, Alexandre
Lledo, Gérard
Brezault, Catherine
Coriat, Romain
author_facet Morgant, Stéphanie
Artru, Pascal
Oudjit, Ammar
Lourenco, Nelson
Pasquer, Arnaud
Walter, Thomas
Gornet, Jean-Marc
Rouquette, Alexandre
Lledo, Gérard
Brezault, Catherine
Coriat, Romain
author_sort Morgant, Stéphanie
collection PubMed
description BACKGROUND: Computed tomography (CT) scan is a key imaging technique in the staging of gastric adenocarcinoma and therapeutic management of patients. The aim of this study was to evaluate the performance of CT scan in the staging of parietal and metastatic invasion in gastric linitis plastica group. METHODS: A retrospective multicentric French study was conducted from January 2006 to December 2015 on patients with no metastatic gastric linitis plastica and operated by gastrec-tomy. A 2/1 matching based on pTNM stage and center was performed. RESULTS: Fifty patients were included in the linitis plastica group and 100 in the control group. Patients from the linitis group were significantly different from those from the control group with a lower age at diagnosis, a more advanced histological lesion, a more frequent undiagnosed peritoneal carcinomatosis, and a higher risk of R1 resection. Sensitivity and specificity of CT scan for the diagnosis of lymph node involvement were 44% and 75%, respectively, in the linitis plastica group and 55% and 60%, respectively, in the control group. The sensitivity and specificity of CT scan for the T3–T4 parietal invasion were 26% and 100%, respectively, in the linitis group and 40% and 72%, respectively, in the control group. CONCLUSION: CT scan has an equal sensitivity and specificity for the evaluation of lymph node and parietal involvement in gastric adenocarcinoma, including linitis plastica. CT scan remains the cornerstone of preoperative evaluation in gastric adenocarcinoma, including linitis plastica. However, CT presents a lack of sensitivity to diagnose low-volume peritoneal carcinomatosis.
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spelling pubmed-61617442018-10-04 Computed tomography scan efficacy in staging gastric linitis plastica lesion: a retrospective multicentric French study Morgant, Stéphanie Artru, Pascal Oudjit, Ammar Lourenco, Nelson Pasquer, Arnaud Walter, Thomas Gornet, Jean-Marc Rouquette, Alexandre Lledo, Gérard Brezault, Catherine Coriat, Romain Cancer Manag Res Original Research BACKGROUND: Computed tomography (CT) scan is a key imaging technique in the staging of gastric adenocarcinoma and therapeutic management of patients. The aim of this study was to evaluate the performance of CT scan in the staging of parietal and metastatic invasion in gastric linitis plastica group. METHODS: A retrospective multicentric French study was conducted from January 2006 to December 2015 on patients with no metastatic gastric linitis plastica and operated by gastrec-tomy. A 2/1 matching based on pTNM stage and center was performed. RESULTS: Fifty patients were included in the linitis plastica group and 100 in the control group. Patients from the linitis group were significantly different from those from the control group with a lower age at diagnosis, a more advanced histological lesion, a more frequent undiagnosed peritoneal carcinomatosis, and a higher risk of R1 resection. Sensitivity and specificity of CT scan for the diagnosis of lymph node involvement were 44% and 75%, respectively, in the linitis plastica group and 55% and 60%, respectively, in the control group. The sensitivity and specificity of CT scan for the T3–T4 parietal invasion were 26% and 100%, respectively, in the linitis group and 40% and 72%, respectively, in the control group. CONCLUSION: CT scan has an equal sensitivity and specificity for the evaluation of lymph node and parietal involvement in gastric adenocarcinoma, including linitis plastica. CT scan remains the cornerstone of preoperative evaluation in gastric adenocarcinoma, including linitis plastica. However, CT presents a lack of sensitivity to diagnose low-volume peritoneal carcinomatosis. Dove Medical Press 2018-09-24 /pmc/articles/PMC6161744/ /pubmed/30288113 http://dx.doi.org/10.2147/CMAR.S163141 Text en © 2018 Morgant et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Morgant, Stéphanie
Artru, Pascal
Oudjit, Ammar
Lourenco, Nelson
Pasquer, Arnaud
Walter, Thomas
Gornet, Jean-Marc
Rouquette, Alexandre
Lledo, Gérard
Brezault, Catherine
Coriat, Romain
Computed tomography scan efficacy in staging gastric linitis plastica lesion: a retrospective multicentric French study
title Computed tomography scan efficacy in staging gastric linitis plastica lesion: a retrospective multicentric French study
title_full Computed tomography scan efficacy in staging gastric linitis plastica lesion: a retrospective multicentric French study
title_fullStr Computed tomography scan efficacy in staging gastric linitis plastica lesion: a retrospective multicentric French study
title_full_unstemmed Computed tomography scan efficacy in staging gastric linitis plastica lesion: a retrospective multicentric French study
title_short Computed tomography scan efficacy in staging gastric linitis plastica lesion: a retrospective multicentric French study
title_sort computed tomography scan efficacy in staging gastric linitis plastica lesion: a retrospective multicentric french study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161744/
https://www.ncbi.nlm.nih.gov/pubmed/30288113
http://dx.doi.org/10.2147/CMAR.S163141
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