Cargando…

Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy

Interleukin-1 receptor-associated kinases (IRAK1, IRAK2, IRAK3 [IRAK-M], and IRAK4) are serine-threonine kinases involved in toll-like receptor and interleukin-1 signaling pathways, through which they regulate innate immunity and inflammation. Evidence exists that IRAKs play key roles in the pathoph...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singer, Jack W., Fleischman, Angela, Al-Fayoumi, Suliman, Mascarenhas, John O., Yu, Qiang, Agarwal, Anupriya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161786/ https://www.ncbi.nlm.nih.gov/pubmed/30279971 http://dx.doi.org/10.18632/oncotarget.26058

Ejemplares similares

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists
por: Vollmer, Stefan, et al.
Publicado: (2017)

IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies
por: Bennett, Joshua, et al.
Publicado: (2022)

Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis
por: Al-Fayoumi, Suliman, et al.
Publicado: (2018)

Comprehensive kinase profile of pacritinib, a nonmyelosuppressive Janus kinase 2 inhibitor
por: Singer, Jack W, et al.
Publicado: (2016)

Interleukin-1 receptor associated kinase 1 (IRAK1) is epigenetically activated in luminal epithelial cells in prostate cancer
por: Schagdarsurengin, Undraga, et al.
Publicado: (2022)

Increased expression of the interleukin-1 receptor-associated kinase (IRAK)-1 is associated with adipose tissue inflammatory state in obesity
por: Ahmad, Rasheed, et al.
Publicado: (2015)

Interleukin-1 Receptor-Associated Kinase 2- and Protein Kinase D1-Dependent Regulation of IRAK-Monocyte Expression by CpG DNA
por: Kim, Young-In, et al.
Publicado: (2012)

Effect of sodium butyrate regulating IRAK1 (interleukin-1 receptor-associated kinase 1) on visceral hypersensitivity in irritable bowel syndrome and its mechanism
por: He, Yuqin, et al.
Publicado: (2021)

Phase 1/2 study of pacritinib, a next generation JAK2/FLT3 inhibitor, in myelofibrosis or other myeloid malignancies
por: Verstovsek, Srdan, et al.
Publicado: (2016)

Interleukin (IL)-1 Receptor–associated Kinase (IRAK) Requirement for Optimal Induction of Multiple IL-1 Signaling Pathways and IL-6 Production
por: Kanakaraj, Palanisamy, et al.
Publicado: (1998)

Interleukin-1 Receptor-Associated Kinase-2 (IRAK2) Is a Critical Mediator of Endoplasmic Reticulum (ER) Stress Signaling
por: Benosman, Samir, et al.
Publicado: (2013)

Inhibition of IRAK1 Is an Effective Therapy for Autoimmune Hypophysitis in Mice
por: Huang, Hsiao-Chen, et al.
Publicado: (2022)

IRAK1: oncotarget in MDS and AML
por: Beverly, Levi J., et al.
Publicado: (2014)

Defective Interleukin (IL)-18–mediated Natural Killer and T Helper Cell Type 1 Responses in IL-1 Receptor–associated Kinase (IRAK)-deficient Mice
por: Kanakaraj, Palanisamy, et al.
Publicado: (1999)

Endotoxin Tolerant Dendritic Cells Suppress Inflammatory Responses in Splenocytes via Interleukin-1 Receptor Associated Kinase (IRAK)-M and Programmed Death-Ligand 1 (PDL-1)
por: Zhou, Yuping, et al.
Publicado: (2018)

The Alphaviral Capsid Protein Inhibits IRAK1-Dependent TLR Signaling
por: Landers, V. Douglas, et al.
Publicado: (2021)

IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel
por: Wee, Zhen Ning, et al.
Publicado: (2015)

Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling
por: De Nardo, Dominic, et al.
Publicado: (2018)

A systematic review and meta-analyses of interleukin-1 receptor associated kinase 3 (IRAK3) action on inflammation in in vivo models for the study of sepsis
por: Nguyen, Trang H., et al.
Publicado: (2022)

Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures
por: Singer, Jack W., et al.
Publicado: (2019)

Distinct Mutations in IRAK-4 Confer Hyporesponsiveness to Lipopolysaccharide and Interleukin-1 in a Patient with Recurrent Bacterial Infections
por: Medvedev, Andrei E., et al.
Publicado: (2003)

1,4-Naphthoquinone Is a Potent Inhibitor of IRAK1 Kinases and the Production of Inflammatory Cytokines in THP-1 Differentiated Macrophages
por: Mahmoud, Ismail Sami, et al.
Publicado: (2021)

Correction: Corrigendum: IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel
por: Wee, Zhen Ning, et al.
Publicado: (2015)

Targeting IRAK1 in T-Cell acute lymphoblastic leukemia
por: Dussiau, Charles, et al.
Publicado: (2015)

Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages
por: Kim, Seung-Jae, et al.
Publicado: (2016)

Helical assembly in the MyD88:IRAK4:IRAK2 complex in TLR/IL-1R signaling
por: Lin, Su-Chang, et al.
Publicado: (2010)

IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis
por: Wang, Yuanyuan, et al.
Publicado: (2023)

The Dietary Flavonoid Kaempferol Mediates Anti-Inflammatory Responses via the Src, Syk, IRAK1, and IRAK4 Molecular Targets
por: Kim, Shi Hyoung, et al.
Publicado: (2015)

Comprehensive Pan-Cancer Analysis of IRAK Family Genes Identifies IRAK1 as a Novel Oncogene in Low-Grade Glioma
por: Li, Jing, et al.
Publicado: (2022)

Inhibition of IRAK1/4 enhances the antitumor effect of lenvatinib in anaplastic thyroid cancer cells
por: Kawamura, Yoshifumi, et al.
Publicado: (2021)

BAP31 regulates IRAK1-dependent neuroinflammation in microglia
por: Liu, Xia, et al.
Publicado: (2019)

Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants
por: Hoyler, Thomas, et al.
Publicado: (2022)

Targeting the Innate Immune Kinase IRAK1 in Radioresistant Cancer: Double-Edged Sword or One-Two Punch?
por: Liu, Peter H., et al.
Publicado: (2019)

Analysis of interleukin-1 receptor associated kinase-3 (IRAK3) function in modulating expression of inflammatory markers in cell culture models: A systematic review and meta-analysis
por: Nguyen, Trang Hong, et al.
Publicado: (2020)

Cloning of IRAK1 and its upregulation in symptomatic mandarin fish infected with ISKNV
por: Zhang, Chao-Zheng, et al.
Publicado: (2009)

Irak : cinco años después /
por: Rosas, María Cristina
Publicado: (2008)

Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding–Defective Mutant of ABIN1
por: Nanda, Sambit K., et al.
Publicado: (2016)

Identification of IRAK1BP1 as a candidate prognostic factor in lung adenocarcinoma
por: Guo, Lei, et al.
Publicado: (2023)

Structural dynamic analysis of apo and ATP-bound IRAK4 kinase
por: Gosu, Vijayakumar, et al.
Publicado: (2014)

IRAK1/4-Targeted Anti-Inflammatory Action of Caffeic Acid
por: Yang, Woo Seok, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_2kderk08ua2ket3a256n83ovb6