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Cancer stem cells in progression of colorectal cancer
Colorectal cancer is one of the most common cancers worldwide with high mortality. Distant metastasis and relapse are major causes of patient death. Cancer stem cells (CSCs) play a critical role in the metastasis and relapse of colorectal cancer. CSCs are a subpopulation of cancer cells with unique...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161799/ https://www.ncbi.nlm.nih.gov/pubmed/30279970 http://dx.doi.org/10.18632/oncotarget.23607 |
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author | Zhou, Yujuan Xia, Longzheng Wang, Heran Oyang, Linda Su, Min Liu, Qiang Lin, Jingguan Tan, Shiming Tian, Yutong Liao, Qianjin Cao, Deliang |
author_facet | Zhou, Yujuan Xia, Longzheng Wang, Heran Oyang, Linda Su, Min Liu, Qiang Lin, Jingguan Tan, Shiming Tian, Yutong Liao, Qianjin Cao, Deliang |
author_sort | Zhou, Yujuan |
collection | PubMed |
description | Colorectal cancer is one of the most common cancers worldwide with high mortality. Distant metastasis and relapse are major causes of patient death. Cancer stem cells (CSCs) play a critical role in the metastasis and relapse of colorectal cancer. CSCs are a subpopulation of cancer cells with unique properties of self-renewal, infinite division and multi-directional differentiation potential. Colorectal CSCs are defined with a group of cell surface markers, such as CD44, CD133, CD24, EpCAM, LGR5 and ALDH. They are highly tumorigenic, chemoresistant and radioresistant and thus are critical in the metastasis and recurrence of colorectal cancer and disease-free survival. This review article updates the colorectal CSCs with a focus on their role in tumor initiation, progression, drug resistance and tumor relapse. |
format | Online Article Text |
id | pubmed-6161799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-61617992018-10-02 Cancer stem cells in progression of colorectal cancer Zhou, Yujuan Xia, Longzheng Wang, Heran Oyang, Linda Su, Min Liu, Qiang Lin, Jingguan Tan, Shiming Tian, Yutong Liao, Qianjin Cao, Deliang Oncotarget Review Colorectal cancer is one of the most common cancers worldwide with high mortality. Distant metastasis and relapse are major causes of patient death. Cancer stem cells (CSCs) play a critical role in the metastasis and relapse of colorectal cancer. CSCs are a subpopulation of cancer cells with unique properties of self-renewal, infinite division and multi-directional differentiation potential. Colorectal CSCs are defined with a group of cell surface markers, such as CD44, CD133, CD24, EpCAM, LGR5 and ALDH. They are highly tumorigenic, chemoresistant and radioresistant and thus are critical in the metastasis and recurrence of colorectal cancer and disease-free survival. This review article updates the colorectal CSCs with a focus on their role in tumor initiation, progression, drug resistance and tumor relapse. Impact Journals LLC 2017-12-22 /pmc/articles/PMC6161799/ /pubmed/30279970 http://dx.doi.org/10.18632/oncotarget.23607 Text en Copyright: © 2018 Zhou et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Review Zhou, Yujuan Xia, Longzheng Wang, Heran Oyang, Linda Su, Min Liu, Qiang Lin, Jingguan Tan, Shiming Tian, Yutong Liao, Qianjin Cao, Deliang Cancer stem cells in progression of colorectal cancer |
title | Cancer stem cells in progression of colorectal cancer |
title_full | Cancer stem cells in progression of colorectal cancer |
title_fullStr | Cancer stem cells in progression of colorectal cancer |
title_full_unstemmed | Cancer stem cells in progression of colorectal cancer |
title_short | Cancer stem cells in progression of colorectal cancer |
title_sort | cancer stem cells in progression of colorectal cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161799/ https://www.ncbi.nlm.nih.gov/pubmed/30279970 http://dx.doi.org/10.18632/oncotarget.23607 |
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