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Outcome reporting bias in trials: a methodological approach for assessment and adjustment in systematic reviews
Systematic reviews of clinical trials aim to include all relevant studies conducted on a particular topic and to provide an unbiased summary of their results, producing the best evidence about the benefits and harms of medical treatments. Relevant studies, however, may not provide the results for al...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group Ltd.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161807/ https://www.ncbi.nlm.nih.gov/pubmed/30266736 http://dx.doi.org/10.1136/bmj.k3802 |
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author | Kirkham, Jamie J Altman, Douglas G Chan, An-Wen Gamble, Carrol Dwan, Kerry M Williamson, Paula R |
author_facet | Kirkham, Jamie J Altman, Douglas G Chan, An-Wen Gamble, Carrol Dwan, Kerry M Williamson, Paula R |
author_sort | Kirkham, Jamie J |
collection | PubMed |
description | Systematic reviews of clinical trials aim to include all relevant studies conducted on a particular topic and to provide an unbiased summary of their results, producing the best evidence about the benefits and harms of medical treatments. Relevant studies, however, may not provide the results for all measured outcomes or may selectively report only some of the analyses undertaken, leading to unnecessary waste in the production and reporting of research, and potentially biasing the conclusions to systematic reviews. In this article, Kirkham and colleagues provide a methodological approach, with an example of how to identify missing outcome data and how to assess and adjust for outcome reporting bias in systematic reviews. |
format | Online Article Text |
id | pubmed-6161807 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BMJ Publishing Group Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61618072018-10-01 Outcome reporting bias in trials: a methodological approach for assessment and adjustment in systematic reviews Kirkham, Jamie J Altman, Douglas G Chan, An-Wen Gamble, Carrol Dwan, Kerry M Williamson, Paula R BMJ Research Methods & Reporting Systematic reviews of clinical trials aim to include all relevant studies conducted on a particular topic and to provide an unbiased summary of their results, producing the best evidence about the benefits and harms of medical treatments. Relevant studies, however, may not provide the results for all measured outcomes or may selectively report only some of the analyses undertaken, leading to unnecessary waste in the production and reporting of research, and potentially biasing the conclusions to systematic reviews. In this article, Kirkham and colleagues provide a methodological approach, with an example of how to identify missing outcome data and how to assess and adjust for outcome reporting bias in systematic reviews. BMJ Publishing Group Ltd. 2018-09-28 /pmc/articles/PMC6161807/ /pubmed/30266736 http://dx.doi.org/10.1136/bmj.k3802 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Methods & Reporting Kirkham, Jamie J Altman, Douglas G Chan, An-Wen Gamble, Carrol Dwan, Kerry M Williamson, Paula R Outcome reporting bias in trials: a methodological approach for assessment and adjustment in systematic reviews |
title | Outcome reporting bias in trials: a methodological approach for assessment and adjustment in systematic reviews |
title_full | Outcome reporting bias in trials: a methodological approach for assessment and adjustment in systematic reviews |
title_fullStr | Outcome reporting bias in trials: a methodological approach for assessment and adjustment in systematic reviews |
title_full_unstemmed | Outcome reporting bias in trials: a methodological approach for assessment and adjustment in systematic reviews |
title_short | Outcome reporting bias in trials: a methodological approach for assessment and adjustment in systematic reviews |
title_sort | outcome reporting bias in trials: a methodological approach for assessment and adjustment in systematic reviews |
topic | Research Methods & Reporting |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161807/ https://www.ncbi.nlm.nih.gov/pubmed/30266736 http://dx.doi.org/10.1136/bmj.k3802 |
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