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Amplification of GTP-cyclohydrolase 1 gene in Plasmodium falciparum isolates with the quadruple mutant of dihydrofolate reductase and dihydropteroate synthase genes in Ghana

Sulfadoxine-pyrimethamine (SP) is used as malaria chemoprophylaxis for pregnant women and children in Ghana. Plasmodium falciparum resistance to SP is linked to mutations in the dihydropteroate synthase gene (pfdhps), dihydrofolate reductase gene (pfdhfr) and amplification of GTP cyclohydrolase 1 (p...

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Detalles Bibliográficos
Autores principales:	Osei, Musah, Ansah, Felix, Matrevi, Sena A., Asante, Kwaku P., Awandare, Gordon A., Quashie, Neils B., Duah, Nancy O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162080/ https://www.ncbi.nlm.nih.gov/pubmed/30265714 http://dx.doi.org/10.1371/journal.pone.0204871

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