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Revisiting Partial Hepatectomy of Large Hepatocellular Carcinoma in Older Patients

Hepatectomy of large hepatocellular carcinomas (>10 cm) in over 70 year-old patients is presumed futile. We retrospectively reviewed 5970 patients with liver tumors Jan 2010 through Dec 2016 in our institute, of them, 37 older patients with large hepatocellular carcinomas staged I-III and Child-P...

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Autores principales: Chen, Guoyong, Zhang, Jiabin, Sun, Jianjun, Wei, Sidong, Chen, Jianbin, Ren, Hui, Zhou, Shaotang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162215/
https://www.ncbi.nlm.nih.gov/pubmed/30266965
http://dx.doi.org/10.1038/s41598-018-32798-0
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author Chen, Guoyong
Zhang, Jiabin
Sun, Jianjun
Wei, Sidong
Chen, Jianbin
Ren, Hui
Zhou, Shaotang
author_facet Chen, Guoyong
Zhang, Jiabin
Sun, Jianjun
Wei, Sidong
Chen, Jianbin
Ren, Hui
Zhou, Shaotang
author_sort Chen, Guoyong
collection PubMed
description Hepatectomy of large hepatocellular carcinomas (>10 cm) in over 70 year-old patients is presumed futile. We retrospectively reviewed 5970 patients with liver tumors Jan 2010 through Dec 2016 in our institute, of them, 37 older patients with large hepatocellular carcinomas staged I-III and Child-Pugh A liver functions receiving conservative treatments (conservative group, n = 37) and 16 older patients with large hepatocellular carcinomas staged I- III who underwent partial hepatectomy (resection group, n = 16) were included, the risk factors for poor survival were analyzed by univariate and multivariate analyses. Compared with the conservative treatments, Partial hepatectomy achieved better median survival time (25.5 months versus 11 months, log-rank = 0.0001) and better median performance status (1 versus 3, p = 0.023), there was different in Charlson comorbidity index (p = 0.019). For the conservative group, the 3-month, 1, 2, 3-year survival rate was 78.4%, 43.2%, 5.4%, 0%; for the resection group, The 3-month, 1, 2, 3-year survival rate was 100%, 93.7.2%, 56.3%, 12.5%; Multivariate Cox regression analysis showed the Charlson comorbidity index and the performance status associated with poor outcomes of those patients (p = 0.001, 0.018, respectively). Resections of large hepatocellular carcinomas in older patients can be performed safely to prolong life expectancy and improve life quality with or without cancer recurrence.
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spelling pubmed-61622152018-10-02 Revisiting Partial Hepatectomy of Large Hepatocellular Carcinoma in Older Patients Chen, Guoyong Zhang, Jiabin Sun, Jianjun Wei, Sidong Chen, Jianbin Ren, Hui Zhou, Shaotang Sci Rep Article Hepatectomy of large hepatocellular carcinomas (>10 cm) in over 70 year-old patients is presumed futile. We retrospectively reviewed 5970 patients with liver tumors Jan 2010 through Dec 2016 in our institute, of them, 37 older patients with large hepatocellular carcinomas staged I-III and Child-Pugh A liver functions receiving conservative treatments (conservative group, n = 37) and 16 older patients with large hepatocellular carcinomas staged I- III who underwent partial hepatectomy (resection group, n = 16) were included, the risk factors for poor survival were analyzed by univariate and multivariate analyses. Compared with the conservative treatments, Partial hepatectomy achieved better median survival time (25.5 months versus 11 months, log-rank = 0.0001) and better median performance status (1 versus 3, p = 0.023), there was different in Charlson comorbidity index (p = 0.019). For the conservative group, the 3-month, 1, 2, 3-year survival rate was 78.4%, 43.2%, 5.4%, 0%; for the resection group, The 3-month, 1, 2, 3-year survival rate was 100%, 93.7.2%, 56.3%, 12.5%; Multivariate Cox regression analysis showed the Charlson comorbidity index and the performance status associated with poor outcomes of those patients (p = 0.001, 0.018, respectively). Resections of large hepatocellular carcinomas in older patients can be performed safely to prolong life expectancy and improve life quality with or without cancer recurrence. Nature Publishing Group UK 2018-09-28 /pmc/articles/PMC6162215/ /pubmed/30266965 http://dx.doi.org/10.1038/s41598-018-32798-0 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chen, Guoyong
Zhang, Jiabin
Sun, Jianjun
Wei, Sidong
Chen, Jianbin
Ren, Hui
Zhou, Shaotang
Revisiting Partial Hepatectomy of Large Hepatocellular Carcinoma in Older Patients
title Revisiting Partial Hepatectomy of Large Hepatocellular Carcinoma in Older Patients
title_full Revisiting Partial Hepatectomy of Large Hepatocellular Carcinoma in Older Patients
title_fullStr Revisiting Partial Hepatectomy of Large Hepatocellular Carcinoma in Older Patients
title_full_unstemmed Revisiting Partial Hepatectomy of Large Hepatocellular Carcinoma in Older Patients
title_short Revisiting Partial Hepatectomy of Large Hepatocellular Carcinoma in Older Patients
title_sort revisiting partial hepatectomy of large hepatocellular carcinoma in older patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162215/
https://www.ncbi.nlm.nih.gov/pubmed/30266965
http://dx.doi.org/10.1038/s41598-018-32798-0
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