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Trastuzumab and paclitaxel in patients with EGFR mutated NSCLC that express HER2 after progression on EGFR TKI treatment
BACKGROUND: HER2 expression and amplification are observed in ~15% of tumour biopsies from patients with a sensitising EGFR mutation who develop EGFR TKI resistance. It is unknown whether HER2 targeting in this setting can result in tumour responses. METHODS: A single arm phase II study was performe...
Autores principales: | de Langen, Adrianus J., Jebbink, M., Hashemi, Sayed M. S., Kuiper, Justine L., de Bruin-Visser, J., Monkhorst, Kim, Thunnissen, Erik, Smit, Egbert F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162232/ https://www.ncbi.nlm.nih.gov/pubmed/30061586 http://dx.doi.org/10.1038/s41416-018-0194-7 |
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