Cargando…

On-chip spatiotemporal electrophysiological analysis of human stem cell derived cardiomyocytes enables quantitative assessment of proarrhythmia in drug development

We examined a simultaneous combined spatiotemporal field potential duration (FPD) and cell-to-cell conduction time (CT) in lined-up shaped human embryonic stem cell-derived cardiomyocytes (hESC-CMs) using an on-chip multielectrode array (MEA) system to evaluate two origins of lethal arrhythmia, repo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Asahi, Yumiko, Hamada, Tomoyo, Hattori, Akihiro, Matsuura, Kenji, Odaka, Masao, Nomura, Fumimasa, Kaneko, Tomoyuki, Abe, Yasuyuki, Takasuna, Kiyoshi, Sanbuissho, Atsushi, Yasuda, Kenji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162288/ https://www.ncbi.nlm.nih.gov/pubmed/30266924 http://dx.doi.org/10.1038/s41598-018-32921-1

Ejemplares similares

On-chip in vitro cell-network pre-clinical cardiac toxicity using spatiotemporal human cardiomyocyte measurement on a chip
por: Kaneko, Tomoyuki, et al.
Publicado: (2014)

On-chip constructive cell-network study (II): on-chip quasi-in vivo cardiac toxicity assay for ventricular tachycardia/fibrillation measurement using ring-shaped closed circuit microelectrode with lined-up cardiomyocyte cell network
por: Nomura, Fumimasa, et al.
Publicado: (2011)

On-chip constructive cell-Network study (I): Contribution of cardiac fibroblasts to cardiomyocyte beating synchronization and community effect
por: Kaneko, Tomoyuki, et al.
Publicado: (2011)

A Non-Destructive Culturing and Cell Sorting Method for Cardiomyocytes and Neurons Using a Double Alginate Layer
por: Terazono, Hideyuki, et al.
Publicado: (2012)

Effect of hydroxychloroquine on proarrhythmia risk assessment using human iPSC-derived cardiomyocytes
por: Yanagida, Shota, et al.
Publicado: (2021)

An on-chip imaging droplet-sorting system: a real-time shape recognition method to screen target cells in droplets with single cell resolution
por: Girault, Mathias, et al.
Publicado: (2017)

Size Distribution Analysis with On-Chip Multi-Imaging Cell Sorter for Unlabeled Identification of Circulating Tumor Cells in Blood
por: Odaka, Masao, et al.
Publicado: (2019)

Proarrhythmia Induced by Propafenone: What is the Mechanism?
por: Femenia, Francisco, et al.
Publicado: (2010)

Transgenic Rabbit Models in Proarrhythmia Research
por: Baczkó, István, et al.
Publicado: (2020)

Proarrhythmia and Oncotherapy: So Much To Be Done!
por: Kovacs, Richard J.
Publicado: (2021)

Deep Learning-Based Proarrhythmia Analysis Using Field Potentials Recorded From Human Pluripotent Stem Cells Derived Cardiomyocytes
Publicado: (2019)

Proarrhythmia in a Patient With Heart Failure on Therapy With Amiodarone
por: Semerdzhieva, Niya E, et al.
Publicado: (2021)

MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia
por: Uddin, Muhammad Erfan, et al.
Publicado: (2022)

Early Drug Discovery Prediction of Proarrhythmia Potential and Its Covariates
por: Polak, Sebastian, et al.
Publicado: (2015)

Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment
por: Dutta, Sara, et al.
Publicado: (2017)

Aging Model for Analyzing Drug-Induced Proarrhythmia Risks Using Cardiomyocytes Differentiated from Progeria-Patient-Derived Induced Pluripotent Stem Cells
por: Daily, Neil, et al.
Publicado: (2023)

Assessment of drug-induced proarrhythmias due to pilsicainide in patients with atrial tachyarrhythmias
por: Koike, Hideki, et al.
Publicado: (2016)

Necessity to evaluate PI3K/Akt signalling pathway in proarrhythmia
por: Ezeani, Martin, et al.
Publicado: (2017)

Corrigendum: Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment
por: Dutta, Sara, et al.
Publicado: (2017)

The Role of the Food and Drug Administration in Drug Development: On the Subject of Proarrhythmia Risk
por: Thind, Munveer, et al.
Publicado: (2020)

Right ventricular lead proarrhythmia: A novel intervention for an under-recognized phenomenon
por: Hayase, Justin, et al.
Publicado: (2017)

Uncertainty assessment of proarrhythmia predictions derived from multi-level in silico models
por: Kopańska, Karolina, et al.
Publicado: (2023)

Cellular Electrophysiology of Iron-Overloaded Cardiomyocytes
por: Siri-Angkul, Natthaphat, et al.
Publicado: (2018)

Automated Algorithm for J-T(peak) and T(peak)-T(end) Assessment of Drug-Induced Proarrhythmia Risk
por: Johannesen, Lars, et al.
Publicado: (2016)

Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative
por: Li, Zhihua, et al.
Publicado: (2018)

CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia
por: Hegyi, Bence, et al.
Publicado: (2021)

Community effect of cardiomyocytes in beating rhythms is determined by stable cells
por: Hayashi, Tatsuya, et al.
Publicado: (2017)

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy
por: Li, Zhihua, et al.
Publicado: (2019)

SARS-CoV-2 spike protein-induced inflammation underlies proarrhythmia in COVID-19
por: Mezache, Louisa, et al.
Publicado: (2023)

Electrophysiological Evidence for Spatiotemporal Flexibility in the Ventrolateral Attention Network
por: Ristic, Jelena, et al.
Publicado: (2011)

Microtechnologies to fuel neurobiological research with nanometer precision
por: Brunello, Cecilia A, et al.
Publicado: (2013)

Emergent synchronous beating behavior in spontaneous beating cardiomyocyte clusters
por: Sakamoto, Kazufumi, et al.
Publicado: (2021)

Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes
por: Lachaud, Quentin, et al.
Publicado: (2022)

Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment
por: Chang, Kelly C., et al.
Publicado: (2017)

The Complex Management of Atrial Fibrillation and Cancer in the COVID-19 Era: Drug Interactions, Thromboembolic Risk, and Proarrhythmia
por: Gatti, Milo, et al.
Publicado: (2020)

Proarrhythmia associated with antiarrhythmic drugs: a comprehensive disproportionality analysis of the FDA adverse event reporting system
por: Wang, Feifei, et al.
Publicado: (2023)

Cardiomyocyte electrophysiology and its modulation: current views and future prospects
por: Huang, Christopher L.-H., et al.
Publicado: (2023)

Applying CiPA paradigm for assessing proarrhythmia risk of Covid-19 current off-label used therapies
por: Delaunois, Annie, et al.
Publicado: (2021)

Development of On-Chip Multi-Imaging Flow Cytometry for Identification of Imaging Biomarkers of Clustered Circulating Tumor Cells
por: Kim, Hyonchol, et al.
Publicado: (2014)

Importance of Spatial Arrangement of Cardiomyocyte Network for Precise and Stable On-Chip Predictive Cardiotoxicity Measurement
por: Sakamoto, Kazufumi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_m32hndpoh6ggqjq315p0q0jhi5