Malaria vaccine candidate based on Duffy-binding protein elicits strain transcending functional antibodies in a Phase I trial

Reticulocyte invasion by Plasmodium vivax requires interaction of the Duffy-binding protein (PvDBP) with host Duffy antigen receptor for chemokines (DARCs). The binding domain of PvDBP maps to a cysteine-rich region referred to as region II (PvDBPII). Blocking this interaction offers a potential pat...

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Detalles Bibliográficos
Autores principales: Singh, Kavita, Mukherjee, Paushali, Shakri, Ahmad Rushdi, Singh, Ankita, Pandey, Gaurav, Bakshi, Meenakshi, Uppal, Geetanjali, Jena, Rajender, Rawat, Ankita, Kumar, Purnima, Bhardwaj, Rukmini, Yazdani, Syed Shams, Hans, Dhiraj, Mehta, Shantanu, Srinivasan, Ajay, Anil, K., Madhusudhan, R. L., Patel, Jaya, Singh, Amit, Rao, Rajeshwar, Gangireddy, Santosh, Patil, Rudrappa, Kaviraj, Swarnendu, Singh, Sanjay, Carter, Darrick, Reed, Steve, Kaslow, David C., Birkett, Ashley, Chauhan, Virander S., Chitnis, Chetan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162314/
https://www.ncbi.nlm.nih.gov/pubmed/30302285
http://dx.doi.org/10.1038/s41541-018-0083-3

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