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Structural basis of neurosteroid anesthetic action on GABA(A) receptors

Type A γ-aminobutyric acid receptors (GABA(A)Rs) are inhibitory pentameric ligand-gated ion channels in the brain. Many anesthetics and neurosteroids act through binding to the GABA(A)R transmembrane domain (TMD), but the structural basis of their actions is not well understood and no resting-state...

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Detalles Bibliográficos
Autores principales:	Chen, Qiang, Wells, Marta M., Arjunan, Palaniappa, Tillman, Tommy S., Cohen, Aina E., Xu, Yan, Tang, Pei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162318/ https://www.ncbi.nlm.nih.gov/pubmed/30266951 http://dx.doi.org/10.1038/s41467-018-06361-4

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