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Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty

Uroguanylin is a 16 amino acid peptide that constitutes a key component of the gut- brain axis with special relevance in body weight regulation. In childhood and adolescence, periods of life with notable metabolic changes; limited data exist, with measurements of pro-uroguanylin in adolescence but n...

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Autores principales: Folgueira, Cintia, Barja-Fernández, Silvia, Gonzalez-Saenz, Patricia, Castelao, Cecilia, Vázquez-Cobela, Rocío, Pena-Leon, Veronica, Ruiz-Piñon, Manuel, Casanueva, Felipe F., Dieguez, Carlos, Leis, Rosaura, Nogueiras, Rubén, Seoane, Luisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162323/
https://www.ncbi.nlm.nih.gov/pubmed/30266914
http://dx.doi.org/10.1038/s41598-018-32767-7
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author Folgueira, Cintia
Barja-Fernández, Silvia
Gonzalez-Saenz, Patricia
Castelao, Cecilia
Vázquez-Cobela, Rocío
Pena-Leon, Veronica
Ruiz-Piñon, Manuel
Casanueva, Felipe F.
Dieguez, Carlos
Leis, Rosaura
Nogueiras, Rubén
Seoane, Luisa M.
author_facet Folgueira, Cintia
Barja-Fernández, Silvia
Gonzalez-Saenz, Patricia
Castelao, Cecilia
Vázquez-Cobela, Rocío
Pena-Leon, Veronica
Ruiz-Piñon, Manuel
Casanueva, Felipe F.
Dieguez, Carlos
Leis, Rosaura
Nogueiras, Rubén
Seoane, Luisa M.
author_sort Folgueira, Cintia
collection PubMed
description Uroguanylin is a 16 amino acid peptide that constitutes a key component of the gut- brain axis with special relevance in body weight regulation. In childhood and adolescence, periods of life with notable metabolic changes; limited data exist, with measurements of pro-uroguanylin in adolescence but not in prepubertal children. This study investigates pro-uroguanylin circulating levels in children with obesity and its relationship with obesity, sex and pubertal development. We analyzed circulating prouroguanylin levels in 117 children (62) and adolescents (55), including 73 with obesity and 44 with normal weight. The pro-uroguanylin concentration is higher in lean girls during pre-puberty versus lean boys (1111 vs 635, p < 0.001). During puberty, pro-uroguanylin levels are higher in lean males with respect to lean females (1060 vs 698, p < 0.01). In girls, a negative correlation exists between pro-uroguanylin and age, Tanner stage, weight, height, BMI (body mass index), waist circumference and plasma levels of leptin and testosterone; a positive correlation was found between pro-uroguanylin and free triiodothyronine. In boys, a positive correlation was found between pro-uroguanylin and BMI and waist circumference and a negative correlation was found with high density lipoprotein-cholesterol. We conclude that a sexual dimorphism exists in circulating pro-uroguanylin levels with respect to BMI. Uroguanylin presents also an opposed circulating pattern during puberty in both sexes.
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spelling pubmed-61623232018-10-02 Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty Folgueira, Cintia Barja-Fernández, Silvia Gonzalez-Saenz, Patricia Castelao, Cecilia Vázquez-Cobela, Rocío Pena-Leon, Veronica Ruiz-Piñon, Manuel Casanueva, Felipe F. Dieguez, Carlos Leis, Rosaura Nogueiras, Rubén Seoane, Luisa M. Sci Rep Article Uroguanylin is a 16 amino acid peptide that constitutes a key component of the gut- brain axis with special relevance in body weight regulation. In childhood and adolescence, periods of life with notable metabolic changes; limited data exist, with measurements of pro-uroguanylin in adolescence but not in prepubertal children. This study investigates pro-uroguanylin circulating levels in children with obesity and its relationship with obesity, sex and pubertal development. We analyzed circulating prouroguanylin levels in 117 children (62) and adolescents (55), including 73 with obesity and 44 with normal weight. The pro-uroguanylin concentration is higher in lean girls during pre-puberty versus lean boys (1111 vs 635, p < 0.001). During puberty, pro-uroguanylin levels are higher in lean males with respect to lean females (1060 vs 698, p < 0.01). In girls, a negative correlation exists between pro-uroguanylin and age, Tanner stage, weight, height, BMI (body mass index), waist circumference and plasma levels of leptin and testosterone; a positive correlation was found between pro-uroguanylin and free triiodothyronine. In boys, a positive correlation was found between pro-uroguanylin and BMI and waist circumference and a negative correlation was found with high density lipoprotein-cholesterol. We conclude that a sexual dimorphism exists in circulating pro-uroguanylin levels with respect to BMI. Uroguanylin presents also an opposed circulating pattern during puberty in both sexes. Nature Publishing Group UK 2018-09-28 /pmc/articles/PMC6162323/ /pubmed/30266914 http://dx.doi.org/10.1038/s41598-018-32767-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Folgueira, Cintia
Barja-Fernández, Silvia
Gonzalez-Saenz, Patricia
Castelao, Cecilia
Vázquez-Cobela, Rocío
Pena-Leon, Veronica
Ruiz-Piñon, Manuel
Casanueva, Felipe F.
Dieguez, Carlos
Leis, Rosaura
Nogueiras, Rubén
Seoane, Luisa M.
Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty
title Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty
title_full Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty
title_fullStr Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty
title_full_unstemmed Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty
title_short Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty
title_sort circulating pro-uroguanylin levels in children and their relation to obesity, sex and puberty
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162323/
https://www.ncbi.nlm.nih.gov/pubmed/30266914
http://dx.doi.org/10.1038/s41598-018-32767-7
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