Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease

Huntington’s disease is a progressive neurodegenerative disorder caused by polyglutamine-expanded mutant huntingtin (mHTT). Here, we show that the deubiquitinase Usp12 rescues mHTT-mediated neurodegeneration in Huntington’s disease rodent and patient-derived human neurons, and in Drosophila. The neu...

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Detalles Bibliográficos
Autores principales: Aron, Rebecca, Pellegrini, Pasquale, Green, Edward W., Maddison, Daniel C., Opoku-Nsiah, Kwadwo, Oliveira, Ana Osório, Wong, Jinny S., Daub, Aaron C., Giorgini, Flaviano, Muchowski, Paul, Finkbeiner, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162324/
https://www.ncbi.nlm.nih.gov/pubmed/30266909
http://dx.doi.org/10.1038/s41467-018-05653-z

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