Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis

Acquisition of new catalytic activity is a relatively rare evolutionary event. A striking example appears in the pathway to the antibiotic lankacidin, as a monoamine oxidase (MAO) family member, LkcE, catalyzes both an unusual amide oxidation, and a subsequent intramolecular Mannich reaction to form...

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Detalles Bibliográficos
Autores principales: Dorival, Jonathan, Risser, Fanny, Jacob, Christophe, Collin, Sabrina, Dräger, Gerald, Paris, Cédric, Chagot, Benjamin, Kirschning, Andreas, Gruez, Arnaud, Weissman, Kira J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162330/
https://www.ncbi.nlm.nih.gov/pubmed/30266997
http://dx.doi.org/10.1038/s41467-018-06323-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162330/
https://www.ncbi.nlm.nih.gov/pubmed/30266997
http://dx.doi.org/10.1038/s41467-018-06323-w

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