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PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes

How cytotoxic T lymphocytes (CTLs) sense T cell receptor (TCR) signaling in order to specialize an area of plasma membrane for granule secretion is not understood. Here, we demonstrate that immune synapse formation led to rapid localized changes in the phosphoinositide composition of the plasma memb...

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Detalles Bibliográficos
Autores principales:	Gawden-Bone, Christian M., Frazer, Gordon L., Richard, Arianne C., Ma, Claire Y., Strege, Katharina, Griffiths, Gillian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162341/ https://www.ncbi.nlm.nih.gov/pubmed/30217409 http://dx.doi.org/10.1016/j.immuni.2018.08.017

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