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Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population

Breast cancer (BC) is one of the most frequent tumors affecting women worldwide. microRNAs (miRNAs) single-nucleotide polymorphisms (SNPs) likely contribute to BC susceptibility. We evaluated the association of five SNPs with BC risk in non-carriers of the BRCA1/2-mutation from a South American popu...

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Autores principales: Morales, Sebastián, De Mayo, Tomas, Gulppi, Felipe Andrés, Gonzalez-Hormazabal, Patricio, Carrasco, Valentina, Reyes, José Miguel, Gómez, Fernando, Waugh, Enrique, Jara, Lilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162394/
https://www.ncbi.nlm.nih.gov/pubmed/30135399
http://dx.doi.org/10.3390/genes9090427
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author Morales, Sebastián
De Mayo, Tomas
Gulppi, Felipe Andrés
Gonzalez-Hormazabal, Patricio
Carrasco, Valentina
Reyes, José Miguel
Gómez, Fernando
Waugh, Enrique
Jara, Lilian
author_facet Morales, Sebastián
De Mayo, Tomas
Gulppi, Felipe Andrés
Gonzalez-Hormazabal, Patricio
Carrasco, Valentina
Reyes, José Miguel
Gómez, Fernando
Waugh, Enrique
Jara, Lilian
author_sort Morales, Sebastián
collection PubMed
description Breast cancer (BC) is one of the most frequent tumors affecting women worldwide. microRNAs (miRNAs) single-nucleotide polymorphisms (SNPs) likely contribute to BC susceptibility. We evaluated the association of five SNPs with BC risk in non-carriers of the BRCA1/2-mutation from a South American population. The SNPs were genotyped in 440 Chilean BRCA1/2-negative BC cases and 1048 controls. Our data do not support an association between rs2910164:G>C or rs3746444:A>G and BC risk. The rs12975333:G>T is monomorphic in the Chilean population. The pre-miR-605 rs2043556-C allele was associated with a decreased risk of BC, both in patients with a strong family history of BC and in early-onset non-familial BC (Odds ratio (OR) = 0.5 [95% confidence interval (CI) 0.4–0.9] p = 0.006 and OR = 0.6 [95% CI 0.5–0.9] p = 0.02, respectively). The rs4541843-T allele is associated with increased risk of familial BC. This is the first association study on rs4541843 and BC risk. Previously, we showed that the TOX3-rs3803662:C>T was significantly associated with increased risk of familial BC. Given that TOX3 mRNA is a target of miR-182, and that both the TOX3 rs3803662-T and pri-miR-182 rs4541843-T alleles are associated with increased BC risk, we evaluated their combined effect. Risk of familial BC increased in a dose-dependent manner with the number of risk alleles (p-trend = 0.0005), indicating an additive effect.
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spelling pubmed-61623942018-10-10 Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population Morales, Sebastián De Mayo, Tomas Gulppi, Felipe Andrés Gonzalez-Hormazabal, Patricio Carrasco, Valentina Reyes, José Miguel Gómez, Fernando Waugh, Enrique Jara, Lilian Genes (Basel) Article Breast cancer (BC) is one of the most frequent tumors affecting women worldwide. microRNAs (miRNAs) single-nucleotide polymorphisms (SNPs) likely contribute to BC susceptibility. We evaluated the association of five SNPs with BC risk in non-carriers of the BRCA1/2-mutation from a South American population. The SNPs were genotyped in 440 Chilean BRCA1/2-negative BC cases and 1048 controls. Our data do not support an association between rs2910164:G>C or rs3746444:A>G and BC risk. The rs12975333:G>T is monomorphic in the Chilean population. The pre-miR-605 rs2043556-C allele was associated with a decreased risk of BC, both in patients with a strong family history of BC and in early-onset non-familial BC (Odds ratio (OR) = 0.5 [95% confidence interval (CI) 0.4–0.9] p = 0.006 and OR = 0.6 [95% CI 0.5–0.9] p = 0.02, respectively). The rs4541843-T allele is associated with increased risk of familial BC. This is the first association study on rs4541843 and BC risk. Previously, we showed that the TOX3-rs3803662:C>T was significantly associated with increased risk of familial BC. Given that TOX3 mRNA is a target of miR-182, and that both the TOX3 rs3803662-T and pri-miR-182 rs4541843-T alleles are associated with increased BC risk, we evaluated their combined effect. Risk of familial BC increased in a dose-dependent manner with the number of risk alleles (p-trend = 0.0005), indicating an additive effect. MDPI 2018-08-22 /pmc/articles/PMC6162394/ /pubmed/30135399 http://dx.doi.org/10.3390/genes9090427 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Morales, Sebastián
De Mayo, Tomas
Gulppi, Felipe Andrés
Gonzalez-Hormazabal, Patricio
Carrasco, Valentina
Reyes, José Miguel
Gómez, Fernando
Waugh, Enrique
Jara, Lilian
Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population
title Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population
title_full Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population
title_fullStr Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population
title_full_unstemmed Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population
title_short Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population
title_sort genetic variants in pre-mir-146a, pre-mir-499, pre-mir-125a, pre-mir-605, and pri-mir-182 are associated with breast cancer susceptibility in a south american population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162394/
https://www.ncbi.nlm.nih.gov/pubmed/30135399
http://dx.doi.org/10.3390/genes9090427
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