The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases

This review article describes and discusses the current knowledge on the general role of the methionine sulfoxide reductase (MSR) system and the particular role of MSR type A (MSRA) in mammals. A powerful tool to investigate the contribution of MSRA to molecular processes within a mammalian system/o...

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Detalles Bibliográficos
Autores principales: Jiang, Beichen, Moskovitz, Jackob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162418/
https://www.ncbi.nlm.nih.gov/pubmed/30231496
http://dx.doi.org/10.3390/antiox7090122
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author Jiang, Beichen
Moskovitz, Jackob
author_facet Jiang, Beichen
Moskovitz, Jackob
author_sort Jiang, Beichen
collection PubMed
description This review article describes and discusses the current knowledge on the general role of the methionine sulfoxide reductase (MSR) system and the particular role of MSR type A (MSRA) in mammals. A powerful tool to investigate the contribution of MSRA to molecular processes within a mammalian system/organism is the MSRA knockout. The deficiency of MSRA in this mouse model provides hints and evidence for this enzyme function in health and disease. Accordingly, the potential involvement of MSRA in the processes leading to neurodegenerative diseases, neurological disorders, cystic fibrosis, cancer, and hearing loss will be deliberated and evaluated.
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spelling pubmed-61624182018-10-02 The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases Jiang, Beichen Moskovitz, Jackob Antioxidants (Basel) Review This review article describes and discusses the current knowledge on the general role of the methionine sulfoxide reductase (MSR) system and the particular role of MSR type A (MSRA) in mammals. A powerful tool to investigate the contribution of MSRA to molecular processes within a mammalian system/organism is the MSRA knockout. The deficiency of MSRA in this mouse model provides hints and evidence for this enzyme function in health and disease. Accordingly, the potential involvement of MSRA in the processes leading to neurodegenerative diseases, neurological disorders, cystic fibrosis, cancer, and hearing loss will be deliberated and evaluated. MDPI 2018-09-18 /pmc/articles/PMC6162418/ /pubmed/30231496 http://dx.doi.org/10.3390/antiox7090122 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jiang, Beichen
Moskovitz, Jackob
The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases
title The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases
title_full The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases
title_fullStr The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases
title_full_unstemmed The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases
title_short The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases
title_sort functions of the mammalian methionine sulfoxide reductase system and related diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162418/
https://www.ncbi.nlm.nih.gov/pubmed/30231496
http://dx.doi.org/10.3390/antiox7090122
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