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Nutrition Impact Symptoms Are Prognostic of Quality of Life and Mortality After Surgery for Oesophageal Cancer

We aimed to clarify the influence of nutritional problems after surgery for oesophageal cancer on functional health related quality of life (HRQOL) and survival. A prospective nationwide cohort of oesophageal cancer patients operated 2001–2005 in Sweden with 6 months postoperative follow up was used...

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Detalles Bibliográficos
Autores principales: Anandavadivelan, Poorna, Martin, Lena, Djärv, Therese, Johar, Asif, Lagergren, Pernilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162430/
https://www.ncbi.nlm.nih.gov/pubmed/30205530
http://dx.doi.org/10.3390/cancers10090318
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author Anandavadivelan, Poorna
Martin, Lena
Djärv, Therese
Johar, Asif
Lagergren, Pernilla
author_facet Anandavadivelan, Poorna
Martin, Lena
Djärv, Therese
Johar, Asif
Lagergren, Pernilla
author_sort Anandavadivelan, Poorna
collection PubMed
description We aimed to clarify the influence of nutritional problems after surgery for oesophageal cancer on functional health related quality of life (HRQOL) and survival. A prospective nationwide cohort of oesophageal cancer patients operated 2001–2005 in Sweden with 6 months postoperative follow up was used. Nutritional problems were categorized as low/moderate/severe/very severe based on weight loss and nutrition impact symptoms. An ANCOVA model calculated mean score differences (MD) with 95% confidence intervals (CI) of global quality of life (QOL), social and physical function scores, stratified by preoperative body mass index (BMI) <25 and ≥25. A Cox proportional hazards model produced hazard ratios (HR) with 95% CI for overall 5-year survival. Of 358 patients, 196 (55%) had preoperative BMI ≥25. Very severe and severe nutritional problems were associated with worse HRQOL in both BMI groups. E.g. MD’s for global QOL among ‘very severe’ group was −29 (95% CI −39–−19) and −20 (95% CI −29–−11) for <25 and ≥25 BMI, respectively, compared to the ‘low’ group. Overall 5-year survival among ‘very severe’ and BMI ≥ 25 was worse; HR 4.6 (95% CI 1.4–15.6). Intense nutritional problems negatively impact postoperative HRQOL and combined with preoperative BMI ≥ 25 are associated with poorer 5-year overall survival representing a group needing greater clinical attention.
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spelling pubmed-61624302018-10-02 Nutrition Impact Symptoms Are Prognostic of Quality of Life and Mortality After Surgery for Oesophageal Cancer Anandavadivelan, Poorna Martin, Lena Djärv, Therese Johar, Asif Lagergren, Pernilla Cancers (Basel) Article We aimed to clarify the influence of nutritional problems after surgery for oesophageal cancer on functional health related quality of life (HRQOL) and survival. A prospective nationwide cohort of oesophageal cancer patients operated 2001–2005 in Sweden with 6 months postoperative follow up was used. Nutritional problems were categorized as low/moderate/severe/very severe based on weight loss and nutrition impact symptoms. An ANCOVA model calculated mean score differences (MD) with 95% confidence intervals (CI) of global quality of life (QOL), social and physical function scores, stratified by preoperative body mass index (BMI) <25 and ≥25. A Cox proportional hazards model produced hazard ratios (HR) with 95% CI for overall 5-year survival. Of 358 patients, 196 (55%) had preoperative BMI ≥25. Very severe and severe nutritional problems were associated with worse HRQOL in both BMI groups. E.g. MD’s for global QOL among ‘very severe’ group was −29 (95% CI −39–−19) and −20 (95% CI −29–−11) for <25 and ≥25 BMI, respectively, compared to the ‘low’ group. Overall 5-year survival among ‘very severe’ and BMI ≥ 25 was worse; HR 4.6 (95% CI 1.4–15.6). Intense nutritional problems negatively impact postoperative HRQOL and combined with preoperative BMI ≥ 25 are associated with poorer 5-year overall survival representing a group needing greater clinical attention. MDPI 2018-09-07 /pmc/articles/PMC6162430/ /pubmed/30205530 http://dx.doi.org/10.3390/cancers10090318 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Anandavadivelan, Poorna
Martin, Lena
Djärv, Therese
Johar, Asif
Lagergren, Pernilla
Nutrition Impact Symptoms Are Prognostic of Quality of Life and Mortality After Surgery for Oesophageal Cancer
title Nutrition Impact Symptoms Are Prognostic of Quality of Life and Mortality After Surgery for Oesophageal Cancer
title_full Nutrition Impact Symptoms Are Prognostic of Quality of Life and Mortality After Surgery for Oesophageal Cancer
title_fullStr Nutrition Impact Symptoms Are Prognostic of Quality of Life and Mortality After Surgery for Oesophageal Cancer
title_full_unstemmed Nutrition Impact Symptoms Are Prognostic of Quality of Life and Mortality After Surgery for Oesophageal Cancer
title_short Nutrition Impact Symptoms Are Prognostic of Quality of Life and Mortality After Surgery for Oesophageal Cancer
title_sort nutrition impact symptoms are prognostic of quality of life and mortality after surgery for oesophageal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162430/
https://www.ncbi.nlm.nih.gov/pubmed/30205530
http://dx.doi.org/10.3390/cancers10090318
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