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Monitoring Fungal Burden and Viability of Sporothrix spp. in Skin Lesions of Cats for Predicting Antifungal Treatment Response
Skin lesions in feline sporotrichosis usually present a high fungal burden, making cats an important source of infection. This study evaluated the fungal burden and isolation in skin lesions of feline sporotrichosis during treatment with itraconazole (ITZ), combined with or without potassium iodide...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162451/ https://www.ncbi.nlm.nih.gov/pubmed/30087237 http://dx.doi.org/10.3390/jof4030092 |
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author | de Miranda, Luisa Helena Monteiro Silva, Jéssica Nunes Gremião, Isabella Dib Ferreira Menezes, Rodrigo Caldas Almeida-Paes, Rodrigo dos Reis, Érica Guerino de Oliveira, Raquel de Vasconcellos Carvalhaes de Araujo, Danuza Salles do Amaral Ferreiro, Laerte Pereira, Sandro Antonio |
author_facet | de Miranda, Luisa Helena Monteiro Silva, Jéssica Nunes Gremião, Isabella Dib Ferreira Menezes, Rodrigo Caldas Almeida-Paes, Rodrigo dos Reis, Érica Guerino de Oliveira, Raquel de Vasconcellos Carvalhaes de Araujo, Danuza Salles do Amaral Ferreiro, Laerte Pereira, Sandro Antonio |
author_sort | de Miranda, Luisa Helena Monteiro |
collection | PubMed |
description | Skin lesions in feline sporotrichosis usually present a high fungal burden, making cats an important source of infection. This study evaluated the fungal burden and isolation in skin lesions of feline sporotrichosis during treatment with itraconazole (ITZ), combined with or without potassium iodide (KI). Treatment-naïve cats with culture-confirmed sporotrichosis and presenting skin ulcers were treated for up to 40 weeks with oral ITZ alone (n = 74) or combined with KI (n = 56). These cats were submitted to monthly sampling of the same lesion for mycological culture and cytopathology until healing of lesion or up to twelve weeks. The fungal burden was expressed as the mean yeast cell count in three microscopic fields from imprint smears. The fungal burden before treatment was significantly higher in cats in which the lesion persisted and in cases of treatment failure when using ITZ alone. After twelve weeks, the median fungal burden decreased to zero in both treatment protocols, suggesting a potential decrease in the risk of transmission of Sporothrix spp. from cats. These findings encourage the early treatment of feline sporotrichosis as a control measure. Moreover, the fungal burden in feline sporotrichosis lesions can be a prognostic indicator and a parameter for choosing appropriate therapeutic regimen. |
format | Online Article Text |
id | pubmed-6162451 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61624512018-10-09 Monitoring Fungal Burden and Viability of Sporothrix spp. in Skin Lesions of Cats for Predicting Antifungal Treatment Response de Miranda, Luisa Helena Monteiro Silva, Jéssica Nunes Gremião, Isabella Dib Ferreira Menezes, Rodrigo Caldas Almeida-Paes, Rodrigo dos Reis, Érica Guerino de Oliveira, Raquel de Vasconcellos Carvalhaes de Araujo, Danuza Salles do Amaral Ferreiro, Laerte Pereira, Sandro Antonio J Fungi (Basel) Article Skin lesions in feline sporotrichosis usually present a high fungal burden, making cats an important source of infection. This study evaluated the fungal burden and isolation in skin lesions of feline sporotrichosis during treatment with itraconazole (ITZ), combined with or without potassium iodide (KI). Treatment-naïve cats with culture-confirmed sporotrichosis and presenting skin ulcers were treated for up to 40 weeks with oral ITZ alone (n = 74) or combined with KI (n = 56). These cats were submitted to monthly sampling of the same lesion for mycological culture and cytopathology until healing of lesion or up to twelve weeks. The fungal burden was expressed as the mean yeast cell count in three microscopic fields from imprint smears. The fungal burden before treatment was significantly higher in cats in which the lesion persisted and in cases of treatment failure when using ITZ alone. After twelve weeks, the median fungal burden decreased to zero in both treatment protocols, suggesting a potential decrease in the risk of transmission of Sporothrix spp. from cats. These findings encourage the early treatment of feline sporotrichosis as a control measure. Moreover, the fungal burden in feline sporotrichosis lesions can be a prognostic indicator and a parameter for choosing appropriate therapeutic regimen. MDPI 2018-08-07 /pmc/articles/PMC6162451/ /pubmed/30087237 http://dx.doi.org/10.3390/jof4030092 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article de Miranda, Luisa Helena Monteiro Silva, Jéssica Nunes Gremião, Isabella Dib Ferreira Menezes, Rodrigo Caldas Almeida-Paes, Rodrigo dos Reis, Érica Guerino de Oliveira, Raquel de Vasconcellos Carvalhaes de Araujo, Danuza Salles do Amaral Ferreiro, Laerte Pereira, Sandro Antonio Monitoring Fungal Burden and Viability of Sporothrix spp. in Skin Lesions of Cats for Predicting Antifungal Treatment Response |
title | Monitoring Fungal Burden and Viability of Sporothrix spp. in Skin Lesions of Cats for Predicting Antifungal Treatment Response |
title_full | Monitoring Fungal Burden and Viability of Sporothrix spp. in Skin Lesions of Cats for Predicting Antifungal Treatment Response |
title_fullStr | Monitoring Fungal Burden and Viability of Sporothrix spp. in Skin Lesions of Cats for Predicting Antifungal Treatment Response |
title_full_unstemmed | Monitoring Fungal Burden and Viability of Sporothrix spp. in Skin Lesions of Cats for Predicting Antifungal Treatment Response |
title_short | Monitoring Fungal Burden and Viability of Sporothrix spp. in Skin Lesions of Cats for Predicting Antifungal Treatment Response |
title_sort | monitoring fungal burden and viability of sporothrix spp. in skin lesions of cats for predicting antifungal treatment response |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162451/ https://www.ncbi.nlm.nih.gov/pubmed/30087237 http://dx.doi.org/10.3390/jof4030092 |
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