Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer

While primarily studied for their roles in innate immune response, the IκB kinase (IKK)-related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic phenotype in a variety of cancers. Additionally, several substrates of these kinases control proliferation, autophagy, cell surviva...

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Detalles Bibliográficos
Autores principales: Durand, Joel K., Zhang, Qing, Baldwin, Albert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162516/
https://www.ncbi.nlm.nih.gov/pubmed/30223576
http://dx.doi.org/10.3390/cells7090139
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author Durand, Joel K.
Zhang, Qing
Baldwin, Albert S.
author_facet Durand, Joel K.
Zhang, Qing
Baldwin, Albert S.
author_sort Durand, Joel K.
collection PubMed
description While primarily studied for their roles in innate immune response, the IκB kinase (IKK)-related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic phenotype in a variety of cancers. Additionally, several substrates of these kinases control proliferation, autophagy, cell survival, and cancer immune responses. Here we review the involvement of TBK1 and IKKε in controlling different cancers and in regulating responses to cancer immunotherapy.
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spelling pubmed-61625162018-10-02 Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer Durand, Joel K. Zhang, Qing Baldwin, Albert S. Cells Review While primarily studied for their roles in innate immune response, the IκB kinase (IKK)-related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic phenotype in a variety of cancers. Additionally, several substrates of these kinases control proliferation, autophagy, cell survival, and cancer immune responses. Here we review the involvement of TBK1 and IKKε in controlling different cancers and in regulating responses to cancer immunotherapy. MDPI 2018-09-15 /pmc/articles/PMC6162516/ /pubmed/30223576 http://dx.doi.org/10.3390/cells7090139 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Durand, Joel K.
Zhang, Qing
Baldwin, Albert S.
Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
title Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
title_full Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
title_fullStr Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
title_full_unstemmed Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
title_short Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
title_sort roles for the ikk-related kinases tbk1 and ikkε in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162516/
https://www.ncbi.nlm.nih.gov/pubmed/30223576
http://dx.doi.org/10.3390/cells7090139
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AT zhangqing rolesfortheikkrelatedkinasestbk1andikkeincancer
AT baldwinalberts rolesfortheikkrelatedkinasestbk1andikkeincancer

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