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Could miRNA Signatures be Useful for Predicting Uterine Sarcoma and Carcinosarcoma Prognosis and Treatment?
Changes in microRNA (miRNA) expression may lead to cancer development and/or contribute to its progression; however, their role in uterine sarcomas is poorly understood. Uterine sarcomas (US) belong to a rare class of heterogeneous tumors, representing about 1% of all gynecologic neoplasms. This stu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162723/ https://www.ncbi.nlm.nih.gov/pubmed/30200635 http://dx.doi.org/10.3390/cancers10090315 |
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author | Gonzalez dos Anjos, Laura de Almeida, Bruna Cristine Gomes de Almeida, Thais Mourão Lavorato Rocha, André De Nardo Maffazioli, Giovana Soares, Fernando Augusto Werneck da Cunha, Isabela Chada Baracat, Edmund Candido Carvalho, Katia |
author_facet | Gonzalez dos Anjos, Laura de Almeida, Bruna Cristine Gomes de Almeida, Thais Mourão Lavorato Rocha, André De Nardo Maffazioli, Giovana Soares, Fernando Augusto Werneck da Cunha, Isabela Chada Baracat, Edmund Candido Carvalho, Katia |
author_sort | Gonzalez dos Anjos, Laura |
collection | PubMed |
description | Changes in microRNA (miRNA) expression may lead to cancer development and/or contribute to its progression; however, their role in uterine sarcomas is poorly understood. Uterine sarcomas (US) belong to a rare class of heterogeneous tumors, representing about 1% of all gynecologic neoplasms. This study aimed to assess the expression profile of 84 cancer-related miRNAs and to evaluate their correlation with clinical pathological features. Eighty-two formalin-fixed paraffin-embedded (FFPE) samples were selected. In leiomyosarcoma (LMS), there was an association of lower cancer-specific survival (CSS) with the downregulation of miR-125a-5p and miR-10a-5p, and the upregulation of miR-196a-5p and miR-34c-5p. In carcinosarcoma (CS), lower CSS was associated with the upregulation of miR-184, and the downregulation of let-7b-5p and miR-124. In endometrial stromal sarcomas (ESS), the upregulation of miR-373-3p, miR-372-3p, and let-7b-5p, and the down-expression of let-7f-5p, miR-23-3p, and let-7b-5p were associated with lower CSS. Only miR-138-5p upregulation was associated with higher survival rates. miR-335-5p, miR-301a-3p, and miR-210-3p were more highly expressed in patients with tumor metastasis and relapse. miR-138-5p, miR-146b-5p, and miR-218-5p expression were associated with higher disease-free survival (DFS) in treated patients. These miRNAs represent potential prediction markers for prognosis and treatment response in these tumors. |
format | Online Article Text |
id | pubmed-6162723 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61627232018-10-02 Could miRNA Signatures be Useful for Predicting Uterine Sarcoma and Carcinosarcoma Prognosis and Treatment? Gonzalez dos Anjos, Laura de Almeida, Bruna Cristine Gomes de Almeida, Thais Mourão Lavorato Rocha, André De Nardo Maffazioli, Giovana Soares, Fernando Augusto Werneck da Cunha, Isabela Chada Baracat, Edmund Candido Carvalho, Katia Cancers (Basel) Article Changes in microRNA (miRNA) expression may lead to cancer development and/or contribute to its progression; however, their role in uterine sarcomas is poorly understood. Uterine sarcomas (US) belong to a rare class of heterogeneous tumors, representing about 1% of all gynecologic neoplasms. This study aimed to assess the expression profile of 84 cancer-related miRNAs and to evaluate their correlation with clinical pathological features. Eighty-two formalin-fixed paraffin-embedded (FFPE) samples were selected. In leiomyosarcoma (LMS), there was an association of lower cancer-specific survival (CSS) with the downregulation of miR-125a-5p and miR-10a-5p, and the upregulation of miR-196a-5p and miR-34c-5p. In carcinosarcoma (CS), lower CSS was associated with the upregulation of miR-184, and the downregulation of let-7b-5p and miR-124. In endometrial stromal sarcomas (ESS), the upregulation of miR-373-3p, miR-372-3p, and let-7b-5p, and the down-expression of let-7f-5p, miR-23-3p, and let-7b-5p were associated with lower CSS. Only miR-138-5p upregulation was associated with higher survival rates. miR-335-5p, miR-301a-3p, and miR-210-3p were more highly expressed in patients with tumor metastasis and relapse. miR-138-5p, miR-146b-5p, and miR-218-5p expression were associated with higher disease-free survival (DFS) in treated patients. These miRNAs represent potential prediction markers for prognosis and treatment response in these tumors. MDPI 2018-09-06 /pmc/articles/PMC6162723/ /pubmed/30200635 http://dx.doi.org/10.3390/cancers10090315 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gonzalez dos Anjos, Laura de Almeida, Bruna Cristine Gomes de Almeida, Thais Mourão Lavorato Rocha, André De Nardo Maffazioli, Giovana Soares, Fernando Augusto Werneck da Cunha, Isabela Chada Baracat, Edmund Candido Carvalho, Katia Could miRNA Signatures be Useful for Predicting Uterine Sarcoma and Carcinosarcoma Prognosis and Treatment? |
title | Could miRNA Signatures be Useful for Predicting Uterine Sarcoma and Carcinosarcoma Prognosis and Treatment? |
title_full | Could miRNA Signatures be Useful for Predicting Uterine Sarcoma and Carcinosarcoma Prognosis and Treatment? |
title_fullStr | Could miRNA Signatures be Useful for Predicting Uterine Sarcoma and Carcinosarcoma Prognosis and Treatment? |
title_full_unstemmed | Could miRNA Signatures be Useful for Predicting Uterine Sarcoma and Carcinosarcoma Prognosis and Treatment? |
title_short | Could miRNA Signatures be Useful for Predicting Uterine Sarcoma and Carcinosarcoma Prognosis and Treatment? |
title_sort | could mirna signatures be useful for predicting uterine sarcoma and carcinosarcoma prognosis and treatment? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162723/ https://www.ncbi.nlm.nih.gov/pubmed/30200635 http://dx.doi.org/10.3390/cancers10090315 |
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