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Light Activated Disinfection in Root Canal Treatment—A Focused Review

Light activated disinfection (LAD) is a strategy for optimizing root canal disinfection by using a highly-selective, targeted killing of bacteria using a combination of photosensitizers and light. Over the past decade, numerous in vitro and clinical studies have been performed to demonstrate the eff...

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Detalles Bibliográficos
Autores principales: Ali, Islam A. Abdelaziz, Neelakantan, Prasanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162728/
https://www.ncbi.nlm.nih.gov/pubmed/29996523
http://dx.doi.org/10.3390/dj6030031
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author Ali, Islam A. Abdelaziz
Neelakantan, Prasanna
author_facet Ali, Islam A. Abdelaziz
Neelakantan, Prasanna
author_sort Ali, Islam A. Abdelaziz
collection PubMed
description Light activated disinfection (LAD) is a strategy for optimizing root canal disinfection by using a highly-selective, targeted killing of bacteria using a combination of photosensitizers and light. Over the past decade, numerous in vitro and clinical studies have been performed to demonstrate the effectiveness of this mode of root canal disinfection. While most studies offer an important understanding of the effectiveness of LAD on monospecies biofilms, few have offered credence to the fact that infections of the root canal system are mediated by polymicrobial biofilms. Hence, it is imperative to understand the effect of LAD on polymicrobial biofilms both in terms of microbial killing and the changes in the biofilm architecture. The aim of this review was to systematically review the literature to evaluate the effect of LAD on dual and multispecies biofilms and demonstrate the antibiofilm effect of LAD. Two databases (PubMed and Scopus) were searched to identify eligible studies using a combination of key words. These studies were reviewed to draw conclusions on the effect of LAD on dual and multi species biofilm and the antibiofilm effect of LAD. It was found that LAD alone may be unable to eradicate dual and multispecies biofilms, but it may enhance the effect of conventional canal debridement strategies. Novel formulations of photosensitizers with nanoparticles showed the potential to inhibit biofilm formation and/or disrupt the biofilm architecture.
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spelling pubmed-61627282018-10-09 Light Activated Disinfection in Root Canal Treatment—A Focused Review Ali, Islam A. Abdelaziz Neelakantan, Prasanna Dent J (Basel) Review Light activated disinfection (LAD) is a strategy for optimizing root canal disinfection by using a highly-selective, targeted killing of bacteria using a combination of photosensitizers and light. Over the past decade, numerous in vitro and clinical studies have been performed to demonstrate the effectiveness of this mode of root canal disinfection. While most studies offer an important understanding of the effectiveness of LAD on monospecies biofilms, few have offered credence to the fact that infections of the root canal system are mediated by polymicrobial biofilms. Hence, it is imperative to understand the effect of LAD on polymicrobial biofilms both in terms of microbial killing and the changes in the biofilm architecture. The aim of this review was to systematically review the literature to evaluate the effect of LAD on dual and multispecies biofilms and demonstrate the antibiofilm effect of LAD. Two databases (PubMed and Scopus) were searched to identify eligible studies using a combination of key words. These studies were reviewed to draw conclusions on the effect of LAD on dual and multi species biofilm and the antibiofilm effect of LAD. It was found that LAD alone may be unable to eradicate dual and multispecies biofilms, but it may enhance the effect of conventional canal debridement strategies. Novel formulations of photosensitizers with nanoparticles showed the potential to inhibit biofilm formation and/or disrupt the biofilm architecture. MDPI 2018-07-10 /pmc/articles/PMC6162728/ /pubmed/29996523 http://dx.doi.org/10.3390/dj6030031 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ali, Islam A. Abdelaziz
Neelakantan, Prasanna
Light Activated Disinfection in Root Canal Treatment—A Focused Review
title Light Activated Disinfection in Root Canal Treatment—A Focused Review
title_full Light Activated Disinfection in Root Canal Treatment—A Focused Review
title_fullStr Light Activated Disinfection in Root Canal Treatment—A Focused Review
title_full_unstemmed Light Activated Disinfection in Root Canal Treatment—A Focused Review
title_short Light Activated Disinfection in Root Canal Treatment—A Focused Review
title_sort light activated disinfection in root canal treatment—a focused review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162728/
https://www.ncbi.nlm.nih.gov/pubmed/29996523
http://dx.doi.org/10.3390/dj6030031
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