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Cervical Dystonia and Executive Function: A Pilot Magnetoencephalography Study

Background: Cervical dystonia (CD) patients have impaired working memory, processing speed and visual-motor integration ability. We used magnetoencephalography (MEG) to investigate changes in cerebral oscillations in CD patients during an executive function test, before and after administration of b...

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Autores principales: Mahajan, Abhimanyu, Zillgitt, Andrew, Alshammaa, Abdullah, Patel, Neepa, Sidiropoulos, Christos, LeWitt, Peter A., Bowyer, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162734/
https://www.ncbi.nlm.nih.gov/pubmed/30135369
http://dx.doi.org/10.3390/brainsci8090159
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author Mahajan, Abhimanyu
Zillgitt, Andrew
Alshammaa, Abdullah
Patel, Neepa
Sidiropoulos, Christos
LeWitt, Peter A.
Bowyer, Susan
author_facet Mahajan, Abhimanyu
Zillgitt, Andrew
Alshammaa, Abdullah
Patel, Neepa
Sidiropoulos, Christos
LeWitt, Peter A.
Bowyer, Susan
author_sort Mahajan, Abhimanyu
collection PubMed
description Background: Cervical dystonia (CD) patients have impaired working memory, processing speed and visual-motor integration ability. We used magnetoencephalography (MEG) to investigate changes in cerebral oscillations in CD patients during an executive function test, before and after administration of botulinum toxin. Methods: MEG data were collected from five CD patients while they performed a visual continuous performance task (CPT), before and after they received a botulinum toxin injection. MEG data was also collected on five controls matched for age and gender. Coherence source imaging was performed to quantify network connectivity of subjects. Results: Controls demonstrated two errors with visual CPT; CD patients demonstrated six and three errors pre- and post-botulinum toxin respectively. After botulinum toxin, mean time from cue to correct response was 0.337 s in controls, 0.390 s in patients before botulinum toxin injection, and 0.366 s after the injection. Differences in coherence between controls and patients were found in the following brain regions: Fronto-frontal, fronto-parietal, fronto-striatal, fronto-occipital, parieto-parietal and temporo-parietal. Intrahemispheric and interhemispheric networks were affected. Post injection, there was minimal change in coherence in the above-mentioned networks. Discussion: Neuropsychological testing suggests difference in coherence in frontal circuits between CD cases and controls during the visual CPT, which may reflect subjects’ increased difficulty with the task. Botulinum toxin is associated with minimal improvement with executive function in CD.
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spelling pubmed-61627342018-10-02 Cervical Dystonia and Executive Function: A Pilot Magnetoencephalography Study Mahajan, Abhimanyu Zillgitt, Andrew Alshammaa, Abdullah Patel, Neepa Sidiropoulos, Christos LeWitt, Peter A. Bowyer, Susan Brain Sci Article Background: Cervical dystonia (CD) patients have impaired working memory, processing speed and visual-motor integration ability. We used magnetoencephalography (MEG) to investigate changes in cerebral oscillations in CD patients during an executive function test, before and after administration of botulinum toxin. Methods: MEG data were collected from five CD patients while they performed a visual continuous performance task (CPT), before and after they received a botulinum toxin injection. MEG data was also collected on five controls matched for age and gender. Coherence source imaging was performed to quantify network connectivity of subjects. Results: Controls demonstrated two errors with visual CPT; CD patients demonstrated six and three errors pre- and post-botulinum toxin respectively. After botulinum toxin, mean time from cue to correct response was 0.337 s in controls, 0.390 s in patients before botulinum toxin injection, and 0.366 s after the injection. Differences in coherence between controls and patients were found in the following brain regions: Fronto-frontal, fronto-parietal, fronto-striatal, fronto-occipital, parieto-parietal and temporo-parietal. Intrahemispheric and interhemispheric networks were affected. Post injection, there was minimal change in coherence in the above-mentioned networks. Discussion: Neuropsychological testing suggests difference in coherence in frontal circuits between CD cases and controls during the visual CPT, which may reflect subjects’ increased difficulty with the task. Botulinum toxin is associated with minimal improvement with executive function in CD. MDPI 2018-08-22 /pmc/articles/PMC6162734/ /pubmed/30135369 http://dx.doi.org/10.3390/brainsci8090159 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mahajan, Abhimanyu
Zillgitt, Andrew
Alshammaa, Abdullah
Patel, Neepa
Sidiropoulos, Christos
LeWitt, Peter A.
Bowyer, Susan
Cervical Dystonia and Executive Function: A Pilot Magnetoencephalography Study
title Cervical Dystonia and Executive Function: A Pilot Magnetoencephalography Study
title_full Cervical Dystonia and Executive Function: A Pilot Magnetoencephalography Study
title_fullStr Cervical Dystonia and Executive Function: A Pilot Magnetoencephalography Study
title_full_unstemmed Cervical Dystonia and Executive Function: A Pilot Magnetoencephalography Study
title_short Cervical Dystonia and Executive Function: A Pilot Magnetoencephalography Study
title_sort cervical dystonia and executive function: a pilot magnetoencephalography study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162734/
https://www.ncbi.nlm.nih.gov/pubmed/30135369
http://dx.doi.org/10.3390/brainsci8090159
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