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Cell-Based Reporter Release Assay to Determine the Potency of Proteolytic Bacterial Neurotoxins

Despite the implementation of cell-based replacement methods, the mouse lethality assay is still frequently used to determine the activity of botulinum toxin (BoNT) for medical use. One explanation is that due to the use of neoepitope-specific antibodies to detect the cleaved BoNT substrate, the cur...

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Detalles Bibliográficos
Autores principales:	Pathe-Neuschäfer-Rube, Andrea, Neuschäfer-Rube, Frank, Haas, Gerald, Langoth-Fehringer, Nina, Püschel, Gerhard Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162785/ https://www.ncbi.nlm.nih.gov/pubmed/30189643 http://dx.doi.org/10.3390/toxins10090360

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