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The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis

It is now well over 100 years since Sunao Tawara clarified the location of the axis of the specialised myocardium responsible for producing coordinated ventricular activation. Prior to that stellar publication, controversies had raged as to how many bundles crossed the place of the atrioventricular...

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Autores principales: Anderson, Robert H., Mori, Shumpei, Spicer, Diane E., Sanchez-Quintana, Damian, Jensen, Bjarke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162790/
https://www.ncbi.nlm.nih.gov/pubmed/30135383
http://dx.doi.org/10.3390/jcdd5030044
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author Anderson, Robert H.
Mori, Shumpei
Spicer, Diane E.
Sanchez-Quintana, Damian
Jensen, Bjarke
author_facet Anderson, Robert H.
Mori, Shumpei
Spicer, Diane E.
Sanchez-Quintana, Damian
Jensen, Bjarke
author_sort Anderson, Robert H.
collection PubMed
description It is now well over 100 years since Sunao Tawara clarified the location of the axis of the specialised myocardium responsible for producing coordinated ventricular activation. Prior to that stellar publication, controversies had raged as to how many bundles crossed the place of the atrioventricular insulation as found in mammalian hearts, as well as the very existence of the bundle initially described by Wilhelm His Junior. It is, perhaps surprising that controversies continue, despite the multiple investigations that have taken place since the publication of Tawara’s monograph. For example, we are still unsure as to the precise substrates for the so-called slow and fast pathways into the atrioventricular node. Much has been done, nonetheless, to characterise the molecular make-up of the specialised pathways, and to clarify their mechanisms of development. Of this work itself, a significant part has emanated from the laboratory coordinated for a quarter of a century by Antoon FM Moorman. In this review, which joins the others in recognising the value of his contributions and collaborations, we review our current understanding of the anatomy, development, and evolution of the atrioventricular conduction axis.
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spelling pubmed-61627902018-10-10 The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis Anderson, Robert H. Mori, Shumpei Spicer, Diane E. Sanchez-Quintana, Damian Jensen, Bjarke J Cardiovasc Dev Dis Review It is now well over 100 years since Sunao Tawara clarified the location of the axis of the specialised myocardium responsible for producing coordinated ventricular activation. Prior to that stellar publication, controversies had raged as to how many bundles crossed the place of the atrioventricular insulation as found in mammalian hearts, as well as the very existence of the bundle initially described by Wilhelm His Junior. It is, perhaps surprising that controversies continue, despite the multiple investigations that have taken place since the publication of Tawara’s monograph. For example, we are still unsure as to the precise substrates for the so-called slow and fast pathways into the atrioventricular node. Much has been done, nonetheless, to characterise the molecular make-up of the specialised pathways, and to clarify their mechanisms of development. Of this work itself, a significant part has emanated from the laboratory coordinated for a quarter of a century by Antoon FM Moorman. In this review, which joins the others in recognising the value of his contributions and collaborations, we review our current understanding of the anatomy, development, and evolution of the atrioventricular conduction axis. MDPI 2018-08-22 /pmc/articles/PMC6162790/ /pubmed/30135383 http://dx.doi.org/10.3390/jcdd5030044 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Anderson, Robert H.
Mori, Shumpei
Spicer, Diane E.
Sanchez-Quintana, Damian
Jensen, Bjarke
The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis
title The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis
title_full The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis
title_fullStr The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis
title_full_unstemmed The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis
title_short The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis
title_sort anatomy, development, and evolution of the atrioventricular conduction axis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162790/
https://www.ncbi.nlm.nih.gov/pubmed/30135383
http://dx.doi.org/10.3390/jcdd5030044
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