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The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis
It is now well over 100 years since Sunao Tawara clarified the location of the axis of the specialised myocardium responsible for producing coordinated ventricular activation. Prior to that stellar publication, controversies had raged as to how many bundles crossed the place of the atrioventricular...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162790/ https://www.ncbi.nlm.nih.gov/pubmed/30135383 http://dx.doi.org/10.3390/jcdd5030044 |
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author | Anderson, Robert H. Mori, Shumpei Spicer, Diane E. Sanchez-Quintana, Damian Jensen, Bjarke |
author_facet | Anderson, Robert H. Mori, Shumpei Spicer, Diane E. Sanchez-Quintana, Damian Jensen, Bjarke |
author_sort | Anderson, Robert H. |
collection | PubMed |
description | It is now well over 100 years since Sunao Tawara clarified the location of the axis of the specialised myocardium responsible for producing coordinated ventricular activation. Prior to that stellar publication, controversies had raged as to how many bundles crossed the place of the atrioventricular insulation as found in mammalian hearts, as well as the very existence of the bundle initially described by Wilhelm His Junior. It is, perhaps surprising that controversies continue, despite the multiple investigations that have taken place since the publication of Tawara’s monograph. For example, we are still unsure as to the precise substrates for the so-called slow and fast pathways into the atrioventricular node. Much has been done, nonetheless, to characterise the molecular make-up of the specialised pathways, and to clarify their mechanisms of development. Of this work itself, a significant part has emanated from the laboratory coordinated for a quarter of a century by Antoon FM Moorman. In this review, which joins the others in recognising the value of his contributions and collaborations, we review our current understanding of the anatomy, development, and evolution of the atrioventricular conduction axis. |
format | Online Article Text |
id | pubmed-6162790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61627902018-10-10 The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis Anderson, Robert H. Mori, Shumpei Spicer, Diane E. Sanchez-Quintana, Damian Jensen, Bjarke J Cardiovasc Dev Dis Review It is now well over 100 years since Sunao Tawara clarified the location of the axis of the specialised myocardium responsible for producing coordinated ventricular activation. Prior to that stellar publication, controversies had raged as to how many bundles crossed the place of the atrioventricular insulation as found in mammalian hearts, as well as the very existence of the bundle initially described by Wilhelm His Junior. It is, perhaps surprising that controversies continue, despite the multiple investigations that have taken place since the publication of Tawara’s monograph. For example, we are still unsure as to the precise substrates for the so-called slow and fast pathways into the atrioventricular node. Much has been done, nonetheless, to characterise the molecular make-up of the specialised pathways, and to clarify their mechanisms of development. Of this work itself, a significant part has emanated from the laboratory coordinated for a quarter of a century by Antoon FM Moorman. In this review, which joins the others in recognising the value of his contributions and collaborations, we review our current understanding of the anatomy, development, and evolution of the atrioventricular conduction axis. MDPI 2018-08-22 /pmc/articles/PMC6162790/ /pubmed/30135383 http://dx.doi.org/10.3390/jcdd5030044 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Anderson, Robert H. Mori, Shumpei Spicer, Diane E. Sanchez-Quintana, Damian Jensen, Bjarke The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis |
title | The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis |
title_full | The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis |
title_fullStr | The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis |
title_full_unstemmed | The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis |
title_short | The Anatomy, Development, and Evolution of the Atrioventricular Conduction Axis |
title_sort | anatomy, development, and evolution of the atrioventricular conduction axis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162790/ https://www.ncbi.nlm.nih.gov/pubmed/30135383 http://dx.doi.org/10.3390/jcdd5030044 |
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