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Idiopathic Nephrotic Syndrome: Characteristics and Identification of Prognostic Factors
There are various histopathological forms of idiopathic nephrotic syndrome, including minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). Whereas some relapse predictor factors have been identified in renal transplantation, the clinical future of idiopathic nephrotic syndrome...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162818/ https://www.ncbi.nlm.nih.gov/pubmed/30205613 http://dx.doi.org/10.3390/jcm7090265 |
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author | Dumas De La Roque, Charlotte Prezelin-Reydit, Mathilde Vermorel, Agathe Lepreux, Sébastien Deminière, Colette Combe, Christian Rigothier, Claire |
author_facet | Dumas De La Roque, Charlotte Prezelin-Reydit, Mathilde Vermorel, Agathe Lepreux, Sébastien Deminière, Colette Combe, Christian Rigothier, Claire |
author_sort | Dumas De La Roque, Charlotte |
collection | PubMed |
description | There are various histopathological forms of idiopathic nephrotic syndrome, including minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). Whereas some relapse predictor factors have been identified in renal transplantation, the clinical future of idiopathic nephrotic syndrome in the native kidney remains uncertain. We designed a multicentric retrospective descriptive cohort study including all patients aged 15 years and over whose renal biopsy confirmed MCD or FSGS between January 2007 and December 2014. We studied 165 patients with idiopathic nephrotic syndrome; 97 with MCD and 68 with FSGS. In the MCD cohort, 91.7% of patients were treated with corticosteroids for a median total duration of 13 months. During 45 months of follow-up, 92.8% of patients achieved remission and 45.5% experienced relapse. In this cohort, 5% of patients experienced terminal kidney disease. With respect to FSGS patients, 51.5% were treated with corticosteroids for a median total duration of 15 months. During 66 months of follow-up, 73.5% of patients achieved remission and 20% experienced relapse. In this cohort, 26.5% of patients experienced terminal kidney disease. No statistical association was observed between clinical and biological initial presentation and relapse occurrence. This study describes the characteristics of a cohort of patients with the nephrotic idiopathic syndromes of MCD and FSGS from the time of renal biopsy and throughout follow-up. |
format | Online Article Text |
id | pubmed-6162818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61628182018-10-02 Idiopathic Nephrotic Syndrome: Characteristics and Identification of Prognostic Factors Dumas De La Roque, Charlotte Prezelin-Reydit, Mathilde Vermorel, Agathe Lepreux, Sébastien Deminière, Colette Combe, Christian Rigothier, Claire J Clin Med Article There are various histopathological forms of idiopathic nephrotic syndrome, including minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). Whereas some relapse predictor factors have been identified in renal transplantation, the clinical future of idiopathic nephrotic syndrome in the native kidney remains uncertain. We designed a multicentric retrospective descriptive cohort study including all patients aged 15 years and over whose renal biopsy confirmed MCD or FSGS between January 2007 and December 2014. We studied 165 patients with idiopathic nephrotic syndrome; 97 with MCD and 68 with FSGS. In the MCD cohort, 91.7% of patients were treated with corticosteroids for a median total duration of 13 months. During 45 months of follow-up, 92.8% of patients achieved remission and 45.5% experienced relapse. In this cohort, 5% of patients experienced terminal kidney disease. With respect to FSGS patients, 51.5% were treated with corticosteroids for a median total duration of 15 months. During 66 months of follow-up, 73.5% of patients achieved remission and 20% experienced relapse. In this cohort, 26.5% of patients experienced terminal kidney disease. No statistical association was observed between clinical and biological initial presentation and relapse occurrence. This study describes the characteristics of a cohort of patients with the nephrotic idiopathic syndromes of MCD and FSGS from the time of renal biopsy and throughout follow-up. MDPI 2018-09-09 /pmc/articles/PMC6162818/ /pubmed/30205613 http://dx.doi.org/10.3390/jcm7090265 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dumas De La Roque, Charlotte Prezelin-Reydit, Mathilde Vermorel, Agathe Lepreux, Sébastien Deminière, Colette Combe, Christian Rigothier, Claire Idiopathic Nephrotic Syndrome: Characteristics and Identification of Prognostic Factors |
title | Idiopathic Nephrotic Syndrome: Characteristics and Identification of Prognostic Factors |
title_full | Idiopathic Nephrotic Syndrome: Characteristics and Identification of Prognostic Factors |
title_fullStr | Idiopathic Nephrotic Syndrome: Characteristics and Identification of Prognostic Factors |
title_full_unstemmed | Idiopathic Nephrotic Syndrome: Characteristics and Identification of Prognostic Factors |
title_short | Idiopathic Nephrotic Syndrome: Characteristics and Identification of Prognostic Factors |
title_sort | idiopathic nephrotic syndrome: characteristics and identification of prognostic factors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162818/ https://www.ncbi.nlm.nih.gov/pubmed/30205613 http://dx.doi.org/10.3390/jcm7090265 |
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