Cargando…
Risk of Incident Non-Valvular Atrial Fibrillation after Dialysis-Requiring Acute Kidney Injury
The influence of acute kidney injury (AKI) on subsequent incident atrial fibrillation (AF) has not yet been fully addressed. This retrospective nationwide cohort study was conducted using Taiwan’s National Health Insurance Research Database from 1 January 2000 to 31 December 2010. A total of 41,463...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162837/ https://www.ncbi.nlm.nih.gov/pubmed/30158498 http://dx.doi.org/10.3390/jcm7090248 |
_version_ | 1783359232741998592 |
---|---|
author | Shiao, Chih-Chung Kan, Wei-Chih Wang, Jian-Jhong Lin, Yu-Feng Chen, Likwang Chueh, Eric Huang, Ya-Ting Chiang, Wen-Po Tseng, Li-Jung Wang, Chih-Hsien Wu, Vin-Cent |
author_facet | Shiao, Chih-Chung Kan, Wei-Chih Wang, Jian-Jhong Lin, Yu-Feng Chen, Likwang Chueh, Eric Huang, Ya-Ting Chiang, Wen-Po Tseng, Li-Jung Wang, Chih-Hsien Wu, Vin-Cent |
author_sort | Shiao, Chih-Chung |
collection | PubMed |
description | The influence of acute kidney injury (AKI) on subsequent incident atrial fibrillation (AF) has not yet been fully addressed. This retrospective nationwide cohort study was conducted using Taiwan’s National Health Insurance Research Database from 1 January 2000 to 31 December 2010. A total of 41,463 patients without a previous AF, mitral valve disease, and hyperthyroidism who developed de novo dialysis-requiring AKI (AKI-D) during their index hospitalization were enrolled. After propensity score matching, “non-recovery group” (n = 2895), “AKI-recovery group” (n = 2895) and “non-AKI group” (control group, n = 5790) were categorized. Within a follow-up period of 6.52 ± 3.88 years (median, 6.87 years), we found that the adjusted risks for subsequent incident AF were increased in both AKI-recovery group (adjusted hazard ratio (aHR) = 1.30; 95% confidence intervals (CI), 1.07–1.58; p ≤ 0.01) and non-recovery group (aHR = 1.62; 95% CI, 1.36–1.94) compared to the non-AKI group. Furthermore, the development of AF carried elevated risks for major adverse cardiac events (aHR = 2.11; 95% CI, 1.83–2.43), ischemic stroke (aHR = 1.33; 95% CI, 1.19–1.49), and all stroke (aHR = 1.28; 95% CI, 1.15–1.43). (all p ≤ 0.001, except otherwise expressed) The authors concluded that AKI-D, even in those who withdrew from temporary dialysis, independently increases the subsequent risk of de novo AF. |
format | Online Article Text |
id | pubmed-6162837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61628372018-10-02 Risk of Incident Non-Valvular Atrial Fibrillation after Dialysis-Requiring Acute Kidney Injury Shiao, Chih-Chung Kan, Wei-Chih Wang, Jian-Jhong Lin, Yu-Feng Chen, Likwang Chueh, Eric Huang, Ya-Ting Chiang, Wen-Po Tseng, Li-Jung Wang, Chih-Hsien Wu, Vin-Cent J Clin Med Article The influence of acute kidney injury (AKI) on subsequent incident atrial fibrillation (AF) has not yet been fully addressed. This retrospective nationwide cohort study was conducted using Taiwan’s National Health Insurance Research Database from 1 January 2000 to 31 December 2010. A total of 41,463 patients without a previous AF, mitral valve disease, and hyperthyroidism who developed de novo dialysis-requiring AKI (AKI-D) during their index hospitalization were enrolled. After propensity score matching, “non-recovery group” (n = 2895), “AKI-recovery group” (n = 2895) and “non-AKI group” (control group, n = 5790) were categorized. Within a follow-up period of 6.52 ± 3.88 years (median, 6.87 years), we found that the adjusted risks for subsequent incident AF were increased in both AKI-recovery group (adjusted hazard ratio (aHR) = 1.30; 95% confidence intervals (CI), 1.07–1.58; p ≤ 0.01) and non-recovery group (aHR = 1.62; 95% CI, 1.36–1.94) compared to the non-AKI group. Furthermore, the development of AF carried elevated risks for major adverse cardiac events (aHR = 2.11; 95% CI, 1.83–2.43), ischemic stroke (aHR = 1.33; 95% CI, 1.19–1.49), and all stroke (aHR = 1.28; 95% CI, 1.15–1.43). (all p ≤ 0.001, except otherwise expressed) The authors concluded that AKI-D, even in those who withdrew from temporary dialysis, independently increases the subsequent risk of de novo AF. MDPI 2018-08-29 /pmc/articles/PMC6162837/ /pubmed/30158498 http://dx.doi.org/10.3390/jcm7090248 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shiao, Chih-Chung Kan, Wei-Chih Wang, Jian-Jhong Lin, Yu-Feng Chen, Likwang Chueh, Eric Huang, Ya-Ting Chiang, Wen-Po Tseng, Li-Jung Wang, Chih-Hsien Wu, Vin-Cent Risk of Incident Non-Valvular Atrial Fibrillation after Dialysis-Requiring Acute Kidney Injury |
title | Risk of Incident Non-Valvular Atrial Fibrillation after Dialysis-Requiring Acute Kidney Injury |
title_full | Risk of Incident Non-Valvular Atrial Fibrillation after Dialysis-Requiring Acute Kidney Injury |
title_fullStr | Risk of Incident Non-Valvular Atrial Fibrillation after Dialysis-Requiring Acute Kidney Injury |
title_full_unstemmed | Risk of Incident Non-Valvular Atrial Fibrillation after Dialysis-Requiring Acute Kidney Injury |
title_short | Risk of Incident Non-Valvular Atrial Fibrillation after Dialysis-Requiring Acute Kidney Injury |
title_sort | risk of incident non-valvular atrial fibrillation after dialysis-requiring acute kidney injury |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162837/ https://www.ncbi.nlm.nih.gov/pubmed/30158498 http://dx.doi.org/10.3390/jcm7090248 |
work_keys_str_mv | AT shiaochihchung riskofincidentnonvalvularatrialfibrillationafterdialysisrequiringacutekidneyinjury AT kanweichih riskofincidentnonvalvularatrialfibrillationafterdialysisrequiringacutekidneyinjury AT wangjianjhong riskofincidentnonvalvularatrialfibrillationafterdialysisrequiringacutekidneyinjury AT linyufeng riskofincidentnonvalvularatrialfibrillationafterdialysisrequiringacutekidneyinjury AT chenlikwang riskofincidentnonvalvularatrialfibrillationafterdialysisrequiringacutekidneyinjury AT chueheric riskofincidentnonvalvularatrialfibrillationafterdialysisrequiringacutekidneyinjury AT huangyating riskofincidentnonvalvularatrialfibrillationafterdialysisrequiringacutekidneyinjury AT chiangwenpo riskofincidentnonvalvularatrialfibrillationafterdialysisrequiringacutekidneyinjury AT tsenglijung riskofincidentnonvalvularatrialfibrillationafterdialysisrequiringacutekidneyinjury AT wangchihhsien riskofincidentnonvalvularatrialfibrillationafterdialysisrequiringacutekidneyinjury AT wuvincent riskofincidentnonvalvularatrialfibrillationafterdialysisrequiringacutekidneyinjury |