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Association of Arrhythmia in Patients with Cervical Spondylosis: A Nationwide Population-Based Cohort Study

Background: Sympathetic activity, including cervical ganglia, is involved in the development of cardiac arrhythmias. Objective: The present study investigated the association between cervical spondylosis and arrhythmia, which has never been reported before. Methods: Patients newly diagnosed with cer...

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Autores principales: Lin, Shih-Yi, Hsu, Wu-Huei, Lin, Cheng-Chieh, Lin, Cheng-Li, Tsai, Chun-Hao, Lin, Chih-Hsueh, Chen, Der-Cherng, Lin, Tsung-Chih, Hsu, Chung-Y., Kao, Chia-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162845/
https://www.ncbi.nlm.nih.gov/pubmed/30142924
http://dx.doi.org/10.3390/jcm7090236
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author Lin, Shih-Yi
Hsu, Wu-Huei
Lin, Cheng-Chieh
Lin, Cheng-Li
Tsai, Chun-Hao
Lin, Chih-Hsueh
Chen, Der-Cherng
Lin, Tsung-Chih
Hsu, Chung-Y.
Kao, Chia-Hung
author_facet Lin, Shih-Yi
Hsu, Wu-Huei
Lin, Cheng-Chieh
Lin, Cheng-Li
Tsai, Chun-Hao
Lin, Chih-Hsueh
Chen, Der-Cherng
Lin, Tsung-Chih
Hsu, Chung-Y.
Kao, Chia-Hung
author_sort Lin, Shih-Yi
collection PubMed
description Background: Sympathetic activity, including cervical ganglia, is involved in the development of cardiac arrhythmias. Objective: The present study investigated the association between cervical spondylosis and arrhythmia, which has never been reported before. Methods: Patients newly diagnosed with cervical spondylosis (CS) with an index date between 2000 and 2011 were identified from the National Health Insurance Research Database. We performed a 1:1 case-control matched analysis. Cases were matched to controls according to their estimated propensity scores, based on demographics and existing risk factors. Cox proportional hazard models were applied to assess the association between CS and arrhythmia. Results: The CS cohort comprised 22,236 patients (males, 42.6%; mean age, 54.4 years) and non-CS cohort comprised 22,236 matched controls. There were 1441 events of arrhythmia in CS cohort and 537 events of arrhythmia in non-CS cohort, which 252 and 127 events of atrial fibrillation in CS and non-CS cohort, 33 and 12 events of ventricular tachycardia in CS cohort and non-CS cohort, 78 and 35 events of supraventricular tachycardia in CS cohort and non-CS cohort. The CS cohort had an arrhythmia incidence of 11.1 per 1000 person-years and a higher risk [adjusted hazard ratio (aHR) = 3.10, 95% confidence interval (CI) = 2.80–3.42] of arrhythmia, 2.54-fold aHR of ventricular tachycardia (95% CI = 1.70–3.79), and 2.22-fold aHR of atrial fibrillation (95% CI = 1.79–2.76) compared with non-CS cohort. Conclusions: Cervical spondylosis is associated with a higher risk of arrhythmia.
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spelling pubmed-61628452018-10-02 Association of Arrhythmia in Patients with Cervical Spondylosis: A Nationwide Population-Based Cohort Study Lin, Shih-Yi Hsu, Wu-Huei Lin, Cheng-Chieh Lin, Cheng-Li Tsai, Chun-Hao Lin, Chih-Hsueh Chen, Der-Cherng Lin, Tsung-Chih Hsu, Chung-Y. Kao, Chia-Hung J Clin Med Article Background: Sympathetic activity, including cervical ganglia, is involved in the development of cardiac arrhythmias. Objective: The present study investigated the association between cervical spondylosis and arrhythmia, which has never been reported before. Methods: Patients newly diagnosed with cervical spondylosis (CS) with an index date between 2000 and 2011 were identified from the National Health Insurance Research Database. We performed a 1:1 case-control matched analysis. Cases were matched to controls according to their estimated propensity scores, based on demographics and existing risk factors. Cox proportional hazard models were applied to assess the association between CS and arrhythmia. Results: The CS cohort comprised 22,236 patients (males, 42.6%; mean age, 54.4 years) and non-CS cohort comprised 22,236 matched controls. There were 1441 events of arrhythmia in CS cohort and 537 events of arrhythmia in non-CS cohort, which 252 and 127 events of atrial fibrillation in CS and non-CS cohort, 33 and 12 events of ventricular tachycardia in CS cohort and non-CS cohort, 78 and 35 events of supraventricular tachycardia in CS cohort and non-CS cohort. The CS cohort had an arrhythmia incidence of 11.1 per 1000 person-years and a higher risk [adjusted hazard ratio (aHR) = 3.10, 95% confidence interval (CI) = 2.80–3.42] of arrhythmia, 2.54-fold aHR of ventricular tachycardia (95% CI = 1.70–3.79), and 2.22-fold aHR of atrial fibrillation (95% CI = 1.79–2.76) compared with non-CS cohort. Conclusions: Cervical spondylosis is associated with a higher risk of arrhythmia. MDPI 2018-08-23 /pmc/articles/PMC6162845/ /pubmed/30142924 http://dx.doi.org/10.3390/jcm7090236 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Shih-Yi
Hsu, Wu-Huei
Lin, Cheng-Chieh
Lin, Cheng-Li
Tsai, Chun-Hao
Lin, Chih-Hsueh
Chen, Der-Cherng
Lin, Tsung-Chih
Hsu, Chung-Y.
Kao, Chia-Hung
Association of Arrhythmia in Patients with Cervical Spondylosis: A Nationwide Population-Based Cohort Study
title Association of Arrhythmia in Patients with Cervical Spondylosis: A Nationwide Population-Based Cohort Study
title_full Association of Arrhythmia in Patients with Cervical Spondylosis: A Nationwide Population-Based Cohort Study
title_fullStr Association of Arrhythmia in Patients with Cervical Spondylosis: A Nationwide Population-Based Cohort Study
title_full_unstemmed Association of Arrhythmia in Patients with Cervical Spondylosis: A Nationwide Population-Based Cohort Study
title_short Association of Arrhythmia in Patients with Cervical Spondylosis: A Nationwide Population-Based Cohort Study
title_sort association of arrhythmia in patients with cervical spondylosis: a nationwide population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162845/
https://www.ncbi.nlm.nih.gov/pubmed/30142924
http://dx.doi.org/10.3390/jcm7090236
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