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Body Fatness and Cardiovascular Health in Newborn Infants
Birth weight is associated with cardiovascular disease, with those at both ends of the spectrum at increased risk. However, birth weight is a crude surrogate of fetal growth. Measures of body composition may more accurately identify high risk infants. We aimed to determine whether aortic wall thicke...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162858/ https://www.ncbi.nlm.nih.gov/pubmed/30208579 http://dx.doi.org/10.3390/jcm7090270 |
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author | Dissanayake, Hasthi U. McMullan, Rowena L. Kong, Yang Caterson, Ian D. Celermajer, David S. Phang, Melinda Raynes-Greenow, Camille Polson, Jaimie W. Gordon, Adrienne Skilton, Michael R. |
author_facet | Dissanayake, Hasthi U. McMullan, Rowena L. Kong, Yang Caterson, Ian D. Celermajer, David S. Phang, Melinda Raynes-Greenow, Camille Polson, Jaimie W. Gordon, Adrienne Skilton, Michael R. |
author_sort | Dissanayake, Hasthi U. |
collection | PubMed |
description | Birth weight is associated with cardiovascular disease, with those at both ends of the spectrum at increased risk. However, birth weight is a crude surrogate of fetal growth. Measures of body composition may more accurately identify high risk infants. We aimed to determine whether aortic wall thickening, cardiac autonomic control, and cardiac structure/function differ in newborns with high or low body fatness compared to those with average body fatness. 189 healthy singleton term born neonates were recruited and stratified by body fat percentiles (sex and gestation-specific). Infants with low body fat had higher aortic intima-media thickness (43 µm (95% confidence interval (CI) 7, 78), p = 0.02), lower heart rate variability (log total power, −0.5 (95% CI −0.8, −0.1), p = 0.008), and thicker ventricular walls (posterior wall thickness, 3.1 mm (95% CI 1.6, 4.6), p < 0.001) compared to infants with average body fatness. Infants with high body fat showed no differences in aortic intima-media thickness (−2 µm (95% CI −37, 33), p = 0.91) or cardiac structure compared to average body fatness, although stroke volume (−0.3 mL/kg (95% CI −0.6, −0.0), p = 0.003) and heart rate variability were lower (log total power, −0.8 (95% CI −1.1, −0.5), p < 0.001). The non-linear association of body fatness with heart rate variability was independent of birth weight. Infants born with low or high body fat have altered markers of cardiovascular health. Assessment of body fatness alongside birth weight may assist in identifying high risk individuals. |
format | Online Article Text |
id | pubmed-6162858 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61628582018-10-02 Body Fatness and Cardiovascular Health in Newborn Infants Dissanayake, Hasthi U. McMullan, Rowena L. Kong, Yang Caterson, Ian D. Celermajer, David S. Phang, Melinda Raynes-Greenow, Camille Polson, Jaimie W. Gordon, Adrienne Skilton, Michael R. J Clin Med Article Birth weight is associated with cardiovascular disease, with those at both ends of the spectrum at increased risk. However, birth weight is a crude surrogate of fetal growth. Measures of body composition may more accurately identify high risk infants. We aimed to determine whether aortic wall thickening, cardiac autonomic control, and cardiac structure/function differ in newborns with high or low body fatness compared to those with average body fatness. 189 healthy singleton term born neonates were recruited and stratified by body fat percentiles (sex and gestation-specific). Infants with low body fat had higher aortic intima-media thickness (43 µm (95% confidence interval (CI) 7, 78), p = 0.02), lower heart rate variability (log total power, −0.5 (95% CI −0.8, −0.1), p = 0.008), and thicker ventricular walls (posterior wall thickness, 3.1 mm (95% CI 1.6, 4.6), p < 0.001) compared to infants with average body fatness. Infants with high body fat showed no differences in aortic intima-media thickness (−2 µm (95% CI −37, 33), p = 0.91) or cardiac structure compared to average body fatness, although stroke volume (−0.3 mL/kg (95% CI −0.6, −0.0), p = 0.003) and heart rate variability were lower (log total power, −0.8 (95% CI −1.1, −0.5), p < 0.001). The non-linear association of body fatness with heart rate variability was independent of birth weight. Infants born with low or high body fat have altered markers of cardiovascular health. Assessment of body fatness alongside birth weight may assist in identifying high risk individuals. MDPI 2018-09-11 /pmc/articles/PMC6162858/ /pubmed/30208579 http://dx.doi.org/10.3390/jcm7090270 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dissanayake, Hasthi U. McMullan, Rowena L. Kong, Yang Caterson, Ian D. Celermajer, David S. Phang, Melinda Raynes-Greenow, Camille Polson, Jaimie W. Gordon, Adrienne Skilton, Michael R. Body Fatness and Cardiovascular Health in Newborn Infants |
title | Body Fatness and Cardiovascular Health in Newborn Infants |
title_full | Body Fatness and Cardiovascular Health in Newborn Infants |
title_fullStr | Body Fatness and Cardiovascular Health in Newborn Infants |
title_full_unstemmed | Body Fatness and Cardiovascular Health in Newborn Infants |
title_short | Body Fatness and Cardiovascular Health in Newborn Infants |
title_sort | body fatness and cardiovascular health in newborn infants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162858/ https://www.ncbi.nlm.nih.gov/pubmed/30208579 http://dx.doi.org/10.3390/jcm7090270 |
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