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Body Fatness and Cardiovascular Health in Newborn Infants

Birth weight is associated with cardiovascular disease, with those at both ends of the spectrum at increased risk. However, birth weight is a crude surrogate of fetal growth. Measures of body composition may more accurately identify high risk infants. We aimed to determine whether aortic wall thicke...

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Autores principales: Dissanayake, Hasthi U., McMullan, Rowena L., Kong, Yang, Caterson, Ian D., Celermajer, David S., Phang, Melinda, Raynes-Greenow, Camille, Polson, Jaimie W., Gordon, Adrienne, Skilton, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162858/
https://www.ncbi.nlm.nih.gov/pubmed/30208579
http://dx.doi.org/10.3390/jcm7090270
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author Dissanayake, Hasthi U.
McMullan, Rowena L.
Kong, Yang
Caterson, Ian D.
Celermajer, David S.
Phang, Melinda
Raynes-Greenow, Camille
Polson, Jaimie W.
Gordon, Adrienne
Skilton, Michael R.
author_facet Dissanayake, Hasthi U.
McMullan, Rowena L.
Kong, Yang
Caterson, Ian D.
Celermajer, David S.
Phang, Melinda
Raynes-Greenow, Camille
Polson, Jaimie W.
Gordon, Adrienne
Skilton, Michael R.
author_sort Dissanayake, Hasthi U.
collection PubMed
description Birth weight is associated with cardiovascular disease, with those at both ends of the spectrum at increased risk. However, birth weight is a crude surrogate of fetal growth. Measures of body composition may more accurately identify high risk infants. We aimed to determine whether aortic wall thickening, cardiac autonomic control, and cardiac structure/function differ in newborns with high or low body fatness compared to those with average body fatness. 189 healthy singleton term born neonates were recruited and stratified by body fat percentiles (sex and gestation-specific). Infants with low body fat had higher aortic intima-media thickness (43 µm (95% confidence interval (CI) 7, 78), p = 0.02), lower heart rate variability (log total power, −0.5 (95% CI −0.8, −0.1), p = 0.008), and thicker ventricular walls (posterior wall thickness, 3.1 mm (95% CI 1.6, 4.6), p < 0.001) compared to infants with average body fatness. Infants with high body fat showed no differences in aortic intima-media thickness (−2 µm (95% CI −37, 33), p = 0.91) or cardiac structure compared to average body fatness, although stroke volume (−0.3 mL/kg (95% CI −0.6, −0.0), p = 0.003) and heart rate variability were lower (log total power, −0.8 (95% CI −1.1, −0.5), p < 0.001). The non-linear association of body fatness with heart rate variability was independent of birth weight. Infants born with low or high body fat have altered markers of cardiovascular health. Assessment of body fatness alongside birth weight may assist in identifying high risk individuals.
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spelling pubmed-61628582018-10-02 Body Fatness and Cardiovascular Health in Newborn Infants Dissanayake, Hasthi U. McMullan, Rowena L. Kong, Yang Caterson, Ian D. Celermajer, David S. Phang, Melinda Raynes-Greenow, Camille Polson, Jaimie W. Gordon, Adrienne Skilton, Michael R. J Clin Med Article Birth weight is associated with cardiovascular disease, with those at both ends of the spectrum at increased risk. However, birth weight is a crude surrogate of fetal growth. Measures of body composition may more accurately identify high risk infants. We aimed to determine whether aortic wall thickening, cardiac autonomic control, and cardiac structure/function differ in newborns with high or low body fatness compared to those with average body fatness. 189 healthy singleton term born neonates were recruited and stratified by body fat percentiles (sex and gestation-specific). Infants with low body fat had higher aortic intima-media thickness (43 µm (95% confidence interval (CI) 7, 78), p = 0.02), lower heart rate variability (log total power, −0.5 (95% CI −0.8, −0.1), p = 0.008), and thicker ventricular walls (posterior wall thickness, 3.1 mm (95% CI 1.6, 4.6), p < 0.001) compared to infants with average body fatness. Infants with high body fat showed no differences in aortic intima-media thickness (−2 µm (95% CI −37, 33), p = 0.91) or cardiac structure compared to average body fatness, although stroke volume (−0.3 mL/kg (95% CI −0.6, −0.0), p = 0.003) and heart rate variability were lower (log total power, −0.8 (95% CI −1.1, −0.5), p < 0.001). The non-linear association of body fatness with heart rate variability was independent of birth weight. Infants born with low or high body fat have altered markers of cardiovascular health. Assessment of body fatness alongside birth weight may assist in identifying high risk individuals. MDPI 2018-09-11 /pmc/articles/PMC6162858/ /pubmed/30208579 http://dx.doi.org/10.3390/jcm7090270 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dissanayake, Hasthi U.
McMullan, Rowena L.
Kong, Yang
Caterson, Ian D.
Celermajer, David S.
Phang, Melinda
Raynes-Greenow, Camille
Polson, Jaimie W.
Gordon, Adrienne
Skilton, Michael R.
Body Fatness and Cardiovascular Health in Newborn Infants
title Body Fatness and Cardiovascular Health in Newborn Infants
title_full Body Fatness and Cardiovascular Health in Newborn Infants
title_fullStr Body Fatness and Cardiovascular Health in Newborn Infants
title_full_unstemmed Body Fatness and Cardiovascular Health in Newborn Infants
title_short Body Fatness and Cardiovascular Health in Newborn Infants
title_sort body fatness and cardiovascular health in newborn infants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162858/
https://www.ncbi.nlm.nih.gov/pubmed/30208579
http://dx.doi.org/10.3390/jcm7090270
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