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Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses
Irinotecan hydrochloride (CPT-11) is used to treat a wide spectrum of malignant tumors. Hangeshashin-to (Japanese herbal medicine TJ-14) is reportedly effective in preventing and controlling diarrhea associated with CPT-11. However, the effect of TJ-14 on tolerability of chemotherapy with CPT-11 has...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162861/ https://www.ncbi.nlm.nih.gov/pubmed/30154384 http://dx.doi.org/10.3390/jcm7090246 |
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author | Urushiyama, Hirokazu Jo, Taisuke Yasunaga, Hideo Michihata, Nobuaki Yamana, Hayato Matsui, Hiroki Hasegawa, Wakae Hiraishi, Yoshihisa Mitani, Akihisa Fushimi, Kiyohide Nagase, Takahide Yamauchi, Yasuhiro |
author_facet | Urushiyama, Hirokazu Jo, Taisuke Yasunaga, Hideo Michihata, Nobuaki Yamana, Hayato Matsui, Hiroki Hasegawa, Wakae Hiraishi, Yoshihisa Mitani, Akihisa Fushimi, Kiyohide Nagase, Takahide Yamauchi, Yasuhiro |
author_sort | Urushiyama, Hirokazu |
collection | PubMed |
description | Irinotecan hydrochloride (CPT-11) is used to treat a wide spectrum of malignant tumors. Hangeshashin-to (Japanese herbal medicine TJ-14) is reportedly effective in preventing and controlling diarrhea associated with CPT-11. However, the effect of TJ-14 on tolerability of chemotherapy with CPT-11 has not been fully investigated. We used the Japanese Diagnosis Procedure Combination inpatient database to retrospectively identify patients who had received CPT-11 on their first admission with and without TJ-14. Patients who did receive TJ-14 (N = 7092) received CPT-11 more often and in larger doses than those who did not receive TJ-14 (N = 82,019). The incidence rate ratio of CPT-11 administration was 1.34 for frequency (95% confidence interval [CI], 1.31–1.38; p < 0.001), and 1.16 for total dose (95% CI, 1.14–1.19; p < 0.001) according to stabilized inverse probability treatment weighting using propensity scores. Instrumental variable analysis showed similar trends. In-hospital mortality was significantly lower in patients who received TJ-14 than in those who did not. Odds ratios of in-hospital death in patients receiving TJ-14 was 0.81 (95% CI, 0.71–0.93; p = 0.002) according to stabilized inverse probability treatment weighting using propensity scores and 0.42 (95% CI, 0.22–0.81; p = 0.009) according to instrumental variable analysis. Our findings indicate that TJ-14 improve the tolerability of CPT-11. |
format | Online Article Text |
id | pubmed-6162861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61628612018-10-02 Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses Urushiyama, Hirokazu Jo, Taisuke Yasunaga, Hideo Michihata, Nobuaki Yamana, Hayato Matsui, Hiroki Hasegawa, Wakae Hiraishi, Yoshihisa Mitani, Akihisa Fushimi, Kiyohide Nagase, Takahide Yamauchi, Yasuhiro J Clin Med Article Irinotecan hydrochloride (CPT-11) is used to treat a wide spectrum of malignant tumors. Hangeshashin-to (Japanese herbal medicine TJ-14) is reportedly effective in preventing and controlling diarrhea associated with CPT-11. However, the effect of TJ-14 on tolerability of chemotherapy with CPT-11 has not been fully investigated. We used the Japanese Diagnosis Procedure Combination inpatient database to retrospectively identify patients who had received CPT-11 on their first admission with and without TJ-14. Patients who did receive TJ-14 (N = 7092) received CPT-11 more often and in larger doses than those who did not receive TJ-14 (N = 82,019). The incidence rate ratio of CPT-11 administration was 1.34 for frequency (95% confidence interval [CI], 1.31–1.38; p < 0.001), and 1.16 for total dose (95% CI, 1.14–1.19; p < 0.001) according to stabilized inverse probability treatment weighting using propensity scores. Instrumental variable analysis showed similar trends. In-hospital mortality was significantly lower in patients who received TJ-14 than in those who did not. Odds ratios of in-hospital death in patients receiving TJ-14 was 0.81 (95% CI, 0.71–0.93; p = 0.002) according to stabilized inverse probability treatment weighting using propensity scores and 0.42 (95% CI, 0.22–0.81; p = 0.009) according to instrumental variable analysis. Our findings indicate that TJ-14 improve the tolerability of CPT-11. MDPI 2018-08-28 /pmc/articles/PMC6162861/ /pubmed/30154384 http://dx.doi.org/10.3390/jcm7090246 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Urushiyama, Hirokazu Jo, Taisuke Yasunaga, Hideo Michihata, Nobuaki Yamana, Hayato Matsui, Hiroki Hasegawa, Wakae Hiraishi, Yoshihisa Mitani, Akihisa Fushimi, Kiyohide Nagase, Takahide Yamauchi, Yasuhiro Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses |
title | Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses |
title_full | Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses |
title_fullStr | Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses |
title_full_unstemmed | Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses |
title_short | Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses |
title_sort | effect of hangeshashin-to (japanese herbal medicine tj-14) on tolerability of irinotecan: propensity score and instrumental variable analyses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162861/ https://www.ncbi.nlm.nih.gov/pubmed/30154384 http://dx.doi.org/10.3390/jcm7090246 |
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