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Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses

Irinotecan hydrochloride (CPT-11) is used to treat a wide spectrum of malignant tumors. Hangeshashin-to (Japanese herbal medicine TJ-14) is reportedly effective in preventing and controlling diarrhea associated with CPT-11. However, the effect of TJ-14 on tolerability of chemotherapy with CPT-11 has...

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Autores principales: Urushiyama, Hirokazu, Jo, Taisuke, Yasunaga, Hideo, Michihata, Nobuaki, Yamana, Hayato, Matsui, Hiroki, Hasegawa, Wakae, Hiraishi, Yoshihisa, Mitani, Akihisa, Fushimi, Kiyohide, Nagase, Takahide, Yamauchi, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162861/
https://www.ncbi.nlm.nih.gov/pubmed/30154384
http://dx.doi.org/10.3390/jcm7090246
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author Urushiyama, Hirokazu
Jo, Taisuke
Yasunaga, Hideo
Michihata, Nobuaki
Yamana, Hayato
Matsui, Hiroki
Hasegawa, Wakae
Hiraishi, Yoshihisa
Mitani, Akihisa
Fushimi, Kiyohide
Nagase, Takahide
Yamauchi, Yasuhiro
author_facet Urushiyama, Hirokazu
Jo, Taisuke
Yasunaga, Hideo
Michihata, Nobuaki
Yamana, Hayato
Matsui, Hiroki
Hasegawa, Wakae
Hiraishi, Yoshihisa
Mitani, Akihisa
Fushimi, Kiyohide
Nagase, Takahide
Yamauchi, Yasuhiro
author_sort Urushiyama, Hirokazu
collection PubMed
description Irinotecan hydrochloride (CPT-11) is used to treat a wide spectrum of malignant tumors. Hangeshashin-to (Japanese herbal medicine TJ-14) is reportedly effective in preventing and controlling diarrhea associated with CPT-11. However, the effect of TJ-14 on tolerability of chemotherapy with CPT-11 has not been fully investigated. We used the Japanese Diagnosis Procedure Combination inpatient database to retrospectively identify patients who had received CPT-11 on their first admission with and without TJ-14. Patients who did receive TJ-14 (N = 7092) received CPT-11 more often and in larger doses than those who did not receive TJ-14 (N = 82,019). The incidence rate ratio of CPT-11 administration was 1.34 for frequency (95% confidence interval [CI], 1.31–1.38; p < 0.001), and 1.16 for total dose (95% CI, 1.14–1.19; p < 0.001) according to stabilized inverse probability treatment weighting using propensity scores. Instrumental variable analysis showed similar trends. In-hospital mortality was significantly lower in patients who received TJ-14 than in those who did not. Odds ratios of in-hospital death in patients receiving TJ-14 was 0.81 (95% CI, 0.71–0.93; p = 0.002) according to stabilized inverse probability treatment weighting using propensity scores and 0.42 (95% CI, 0.22–0.81; p = 0.009) according to instrumental variable analysis. Our findings indicate that TJ-14 improve the tolerability of CPT-11.
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spelling pubmed-61628612018-10-02 Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses Urushiyama, Hirokazu Jo, Taisuke Yasunaga, Hideo Michihata, Nobuaki Yamana, Hayato Matsui, Hiroki Hasegawa, Wakae Hiraishi, Yoshihisa Mitani, Akihisa Fushimi, Kiyohide Nagase, Takahide Yamauchi, Yasuhiro J Clin Med Article Irinotecan hydrochloride (CPT-11) is used to treat a wide spectrum of malignant tumors. Hangeshashin-to (Japanese herbal medicine TJ-14) is reportedly effective in preventing and controlling diarrhea associated with CPT-11. However, the effect of TJ-14 on tolerability of chemotherapy with CPT-11 has not been fully investigated. We used the Japanese Diagnosis Procedure Combination inpatient database to retrospectively identify patients who had received CPT-11 on their first admission with and without TJ-14. Patients who did receive TJ-14 (N = 7092) received CPT-11 more often and in larger doses than those who did not receive TJ-14 (N = 82,019). The incidence rate ratio of CPT-11 administration was 1.34 for frequency (95% confidence interval [CI], 1.31–1.38; p < 0.001), and 1.16 for total dose (95% CI, 1.14–1.19; p < 0.001) according to stabilized inverse probability treatment weighting using propensity scores. Instrumental variable analysis showed similar trends. In-hospital mortality was significantly lower in patients who received TJ-14 than in those who did not. Odds ratios of in-hospital death in patients receiving TJ-14 was 0.81 (95% CI, 0.71–0.93; p = 0.002) according to stabilized inverse probability treatment weighting using propensity scores and 0.42 (95% CI, 0.22–0.81; p = 0.009) according to instrumental variable analysis. Our findings indicate that TJ-14 improve the tolerability of CPT-11. MDPI 2018-08-28 /pmc/articles/PMC6162861/ /pubmed/30154384 http://dx.doi.org/10.3390/jcm7090246 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Urushiyama, Hirokazu
Jo, Taisuke
Yasunaga, Hideo
Michihata, Nobuaki
Yamana, Hayato
Matsui, Hiroki
Hasegawa, Wakae
Hiraishi, Yoshihisa
Mitani, Akihisa
Fushimi, Kiyohide
Nagase, Takahide
Yamauchi, Yasuhiro
Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses
title Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses
title_full Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses
title_fullStr Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses
title_full_unstemmed Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses
title_short Effect of Hangeshashin-To (Japanese Herbal Medicine Tj-14) on Tolerability of Irinotecan: Propensity Score and Instrumental Variable Analyses
title_sort effect of hangeshashin-to (japanese herbal medicine tj-14) on tolerability of irinotecan: propensity score and instrumental variable analyses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162861/
https://www.ncbi.nlm.nih.gov/pubmed/30154384
http://dx.doi.org/10.3390/jcm7090246
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