Cargando…

Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse

The origin of spontaneous preference for dietary lipids in humans and rodents is debated, though recent compelling evidence has shown the existence of fat taste that might be considered a sixth taste quality. We investigated the implication of gustatory and reward brain circuits, triggered by linole...

Descripción completa

Detalles Bibliográficos
Autores principales: Peterschmitt, Yvan, Abdoul-Azize, Souleymane, Murtaza, Babar, Barbier, Marie, Khan, Amira Sayed, Millot, Jean-Louis, Khan, Naim Akhtar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163273/
https://www.ncbi.nlm.nih.gov/pubmed/30200577
http://dx.doi.org/10.3390/nu10091246
_version_ 1783359320820285440
author Peterschmitt, Yvan
Abdoul-Azize, Souleymane
Murtaza, Babar
Barbier, Marie
Khan, Amira Sayed
Millot, Jean-Louis
Khan, Naim Akhtar
author_facet Peterschmitt, Yvan
Abdoul-Azize, Souleymane
Murtaza, Babar
Barbier, Marie
Khan, Amira Sayed
Millot, Jean-Louis
Khan, Naim Akhtar
author_sort Peterschmitt, Yvan
collection PubMed
description The origin of spontaneous preference for dietary lipids in humans and rodents is debated, though recent compelling evidence has shown the existence of fat taste that might be considered a sixth taste quality. We investigated the implication of gustatory and reward brain circuits, triggered by linoleic acid (LA), a long-chain fatty acid. The LA was applied onto the circumvallate papillae for 30 min in conscious C57BL/6J mice, and neuronal activation was assessed using c-Fos immunohistochemistry. By using real-time reverse transcription polymerase chain reaction (RT-qPCR), we also studied the expression of mRNA encoding brain-derived neurotrophic factor (BDNF), Zif-268, and Glut-1 in some brain areas of these animals. LA induced a significant increase in c-Fos expression in the nucleus of solitary tract (NST), parabrachial nucleus (PBN), and ventroposterior medialis parvocellularis (VPMPC) of the thalamus, which are the regions known to be activated by gustatory signals. LA also triggered c-Fos expression in the central amygdala and ventral tegmental area (VTA), involved in food reward, in conjunction with emotional traits. Interestingly, we noticed a high expression of BDNF, Zif-268, and Glut-1 mRNA in the arcuate nucleus (Arc) and hippocampus (Hipp), where neuronal activation leads to memory formation. Our study demonstrates that oral lipid taste perception might trigger the activation of canonical gustatory and reward pathways.
format Online
Article
Text
id pubmed-6163273
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61632732018-10-10 Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse Peterschmitt, Yvan Abdoul-Azize, Souleymane Murtaza, Babar Barbier, Marie Khan, Amira Sayed Millot, Jean-Louis Khan, Naim Akhtar Nutrients Article The origin of spontaneous preference for dietary lipids in humans and rodents is debated, though recent compelling evidence has shown the existence of fat taste that might be considered a sixth taste quality. We investigated the implication of gustatory and reward brain circuits, triggered by linoleic acid (LA), a long-chain fatty acid. The LA was applied onto the circumvallate papillae for 30 min in conscious C57BL/6J mice, and neuronal activation was assessed using c-Fos immunohistochemistry. By using real-time reverse transcription polymerase chain reaction (RT-qPCR), we also studied the expression of mRNA encoding brain-derived neurotrophic factor (BDNF), Zif-268, and Glut-1 in some brain areas of these animals. LA induced a significant increase in c-Fos expression in the nucleus of solitary tract (NST), parabrachial nucleus (PBN), and ventroposterior medialis parvocellularis (VPMPC) of the thalamus, which are the regions known to be activated by gustatory signals. LA also triggered c-Fos expression in the central amygdala and ventral tegmental area (VTA), involved in food reward, in conjunction with emotional traits. Interestingly, we noticed a high expression of BDNF, Zif-268, and Glut-1 mRNA in the arcuate nucleus (Arc) and hippocampus (Hipp), where neuronal activation leads to memory formation. Our study demonstrates that oral lipid taste perception might trigger the activation of canonical gustatory and reward pathways. MDPI 2018-09-06 /pmc/articles/PMC6163273/ /pubmed/30200577 http://dx.doi.org/10.3390/nu10091246 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Peterschmitt, Yvan
Abdoul-Azize, Souleymane
Murtaza, Babar
Barbier, Marie
Khan, Amira Sayed
Millot, Jean-Louis
Khan, Naim Akhtar
Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse
title Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse
title_full Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse
title_fullStr Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse
title_full_unstemmed Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse
title_short Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse
title_sort fatty acid lingual application activates gustatory and reward brain circuits in the mouse
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163273/
https://www.ncbi.nlm.nih.gov/pubmed/30200577
http://dx.doi.org/10.3390/nu10091246
work_keys_str_mv AT peterschmittyvan fattyacidlingualapplicationactivatesgustatoryandrewardbraincircuitsinthemouse
AT abdoulazizesouleymane fattyacidlingualapplicationactivatesgustatoryandrewardbraincircuitsinthemouse
AT murtazababar fattyacidlingualapplicationactivatesgustatoryandrewardbraincircuitsinthemouse
AT barbiermarie fattyacidlingualapplicationactivatesgustatoryandrewardbraincircuitsinthemouse
AT khanamirasayed fattyacidlingualapplicationactivatesgustatoryandrewardbraincircuitsinthemouse
AT millotjeanlouis fattyacidlingualapplicationactivatesgustatoryandrewardbraincircuitsinthemouse
AT khannaimakhtar fattyacidlingualapplicationactivatesgustatoryandrewardbraincircuitsinthemouse