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Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse
The origin of spontaneous preference for dietary lipids in humans and rodents is debated, though recent compelling evidence has shown the existence of fat taste that might be considered a sixth taste quality. We investigated the implication of gustatory and reward brain circuits, triggered by linole...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163273/ https://www.ncbi.nlm.nih.gov/pubmed/30200577 http://dx.doi.org/10.3390/nu10091246 |
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author | Peterschmitt, Yvan Abdoul-Azize, Souleymane Murtaza, Babar Barbier, Marie Khan, Amira Sayed Millot, Jean-Louis Khan, Naim Akhtar |
author_facet | Peterschmitt, Yvan Abdoul-Azize, Souleymane Murtaza, Babar Barbier, Marie Khan, Amira Sayed Millot, Jean-Louis Khan, Naim Akhtar |
author_sort | Peterschmitt, Yvan |
collection | PubMed |
description | The origin of spontaneous preference for dietary lipids in humans and rodents is debated, though recent compelling evidence has shown the existence of fat taste that might be considered a sixth taste quality. We investigated the implication of gustatory and reward brain circuits, triggered by linoleic acid (LA), a long-chain fatty acid. The LA was applied onto the circumvallate papillae for 30 min in conscious C57BL/6J mice, and neuronal activation was assessed using c-Fos immunohistochemistry. By using real-time reverse transcription polymerase chain reaction (RT-qPCR), we also studied the expression of mRNA encoding brain-derived neurotrophic factor (BDNF), Zif-268, and Glut-1 in some brain areas of these animals. LA induced a significant increase in c-Fos expression in the nucleus of solitary tract (NST), parabrachial nucleus (PBN), and ventroposterior medialis parvocellularis (VPMPC) of the thalamus, which are the regions known to be activated by gustatory signals. LA also triggered c-Fos expression in the central amygdala and ventral tegmental area (VTA), involved in food reward, in conjunction with emotional traits. Interestingly, we noticed a high expression of BDNF, Zif-268, and Glut-1 mRNA in the arcuate nucleus (Arc) and hippocampus (Hipp), where neuronal activation leads to memory formation. Our study demonstrates that oral lipid taste perception might trigger the activation of canonical gustatory and reward pathways. |
format | Online Article Text |
id | pubmed-6163273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61632732018-10-10 Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse Peterschmitt, Yvan Abdoul-Azize, Souleymane Murtaza, Babar Barbier, Marie Khan, Amira Sayed Millot, Jean-Louis Khan, Naim Akhtar Nutrients Article The origin of spontaneous preference for dietary lipids in humans and rodents is debated, though recent compelling evidence has shown the existence of fat taste that might be considered a sixth taste quality. We investigated the implication of gustatory and reward brain circuits, triggered by linoleic acid (LA), a long-chain fatty acid. The LA was applied onto the circumvallate papillae for 30 min in conscious C57BL/6J mice, and neuronal activation was assessed using c-Fos immunohistochemistry. By using real-time reverse transcription polymerase chain reaction (RT-qPCR), we also studied the expression of mRNA encoding brain-derived neurotrophic factor (BDNF), Zif-268, and Glut-1 in some brain areas of these animals. LA induced a significant increase in c-Fos expression in the nucleus of solitary tract (NST), parabrachial nucleus (PBN), and ventroposterior medialis parvocellularis (VPMPC) of the thalamus, which are the regions known to be activated by gustatory signals. LA also triggered c-Fos expression in the central amygdala and ventral tegmental area (VTA), involved in food reward, in conjunction with emotional traits. Interestingly, we noticed a high expression of BDNF, Zif-268, and Glut-1 mRNA in the arcuate nucleus (Arc) and hippocampus (Hipp), where neuronal activation leads to memory formation. Our study demonstrates that oral lipid taste perception might trigger the activation of canonical gustatory and reward pathways. MDPI 2018-09-06 /pmc/articles/PMC6163273/ /pubmed/30200577 http://dx.doi.org/10.3390/nu10091246 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Peterschmitt, Yvan Abdoul-Azize, Souleymane Murtaza, Babar Barbier, Marie Khan, Amira Sayed Millot, Jean-Louis Khan, Naim Akhtar Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse |
title | Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse |
title_full | Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse |
title_fullStr | Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse |
title_full_unstemmed | Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse |
title_short | Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse |
title_sort | fatty acid lingual application activates gustatory and reward brain circuits in the mouse |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163273/ https://www.ncbi.nlm.nih.gov/pubmed/30200577 http://dx.doi.org/10.3390/nu10091246 |
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