The Beneficial Effect of Proanthocyanidins and Icariin on Biochemical Markers of Bone Turnover in Rats

Nutrition is an important factor that influences bone metabolism, the endocrine and/or paracrine system, and bone-active mineral elements homeostasis. We studied antiosteoporotic effects of grape seed proanthocyanidins extract, icariin or alendronate (ALN) in retinoic acid-induced (13cRA) bone loss...

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Autores principales: Oršolić, Nada, Nemrava, Johann, Jeleč, Željko, Kukolj, Marina, Odeh, Dyana, Terzić, Svjetlana, Fureš, Rajko, Bagatin, Tomica, Bagatin, Dinko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163320/
https://www.ncbi.nlm.nih.gov/pubmed/30217029
http://dx.doi.org/10.3390/ijms19092746
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author Oršolić, Nada
Nemrava, Johann
Jeleč, Željko
Kukolj, Marina
Odeh, Dyana
Terzić, Svjetlana
Fureš, Rajko
Bagatin, Tomica
Bagatin, Dinko
author_facet Oršolić, Nada
Nemrava, Johann
Jeleč, Željko
Kukolj, Marina
Odeh, Dyana
Terzić, Svjetlana
Fureš, Rajko
Bagatin, Tomica
Bagatin, Dinko
author_sort Oršolić, Nada
collection PubMed
description Nutrition is an important factor that influences bone metabolism, the endocrine and/or paracrine system, and bone-active mineral elements homeostasis. We studied antiosteoporotic effects of grape seed proanthocyanidins extract, icariin or alendronate (ALN) in retinoic acid-induced (13cRA) bone loss in rats. Proanthocyanidins and icariin have beneficial effects on bone health; they have improved the bone weight reduction, the length and the diameter of the bone, calcium, and phosphorus content in bone ash, bone mineral density (BMD), the biochemical markers of bone turnover and uterus atrophy induced by 13cRA. All results suggest that proanthocyanidins and icariin reverse osteoporosis in 13cRA rats by stimulating bone formation or regulating bone resorption by their antioxidative and estrogenic-like activity without toxic side-effects observed in ALN treatment.
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spelling pubmed-61633202018-10-10 The Beneficial Effect of Proanthocyanidins and Icariin on Biochemical Markers of Bone Turnover in Rats Oršolić, Nada Nemrava, Johann Jeleč, Željko Kukolj, Marina Odeh, Dyana Terzić, Svjetlana Fureš, Rajko Bagatin, Tomica Bagatin, Dinko Int J Mol Sci Article Nutrition is an important factor that influences bone metabolism, the endocrine and/or paracrine system, and bone-active mineral elements homeostasis. We studied antiosteoporotic effects of grape seed proanthocyanidins extract, icariin or alendronate (ALN) in retinoic acid-induced (13cRA) bone loss in rats. Proanthocyanidins and icariin have beneficial effects on bone health; they have improved the bone weight reduction, the length and the diameter of the bone, calcium, and phosphorus content in bone ash, bone mineral density (BMD), the biochemical markers of bone turnover and uterus atrophy induced by 13cRA. All results suggest that proanthocyanidins and icariin reverse osteoporosis in 13cRA rats by stimulating bone formation or regulating bone resorption by their antioxidative and estrogenic-like activity without toxic side-effects observed in ALN treatment. MDPI 2018-09-13 /pmc/articles/PMC6163320/ /pubmed/30217029 http://dx.doi.org/10.3390/ijms19092746 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Oršolić, Nada
Nemrava, Johann
Jeleč, Željko
Kukolj, Marina
Odeh, Dyana
Terzić, Svjetlana
Fureš, Rajko
Bagatin, Tomica
Bagatin, Dinko
The Beneficial Effect of Proanthocyanidins and Icariin on Biochemical Markers of Bone Turnover in Rats
title The Beneficial Effect of Proanthocyanidins and Icariin on Biochemical Markers of Bone Turnover in Rats
title_full The Beneficial Effect of Proanthocyanidins and Icariin on Biochemical Markers of Bone Turnover in Rats
title_fullStr The Beneficial Effect of Proanthocyanidins and Icariin on Biochemical Markers of Bone Turnover in Rats
title_full_unstemmed The Beneficial Effect of Proanthocyanidins and Icariin on Biochemical Markers of Bone Turnover in Rats
title_short The Beneficial Effect of Proanthocyanidins and Icariin on Biochemical Markers of Bone Turnover in Rats
title_sort beneficial effect of proanthocyanidins and icariin on biochemical markers of bone turnover in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163320/
https://www.ncbi.nlm.nih.gov/pubmed/30217029
http://dx.doi.org/10.3390/ijms19092746
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