New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp. ZZ745

As part of our research to discover novel bioactive natural products from marine microorganisms, five bagremycin analogues, including the previously unreported bagremycins F (1) and G (2), were isolated from a marine actinomycete Streptomyces sp. ZZ745. The structures of these compounds were determi...

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Detalles Bibliográficos
Autores principales: Zhang, Di, Shu, Chenyan, Lian, Xiaoyuan, Zhang, Zhizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163353/
https://www.ncbi.nlm.nih.gov/pubmed/30213054
http://dx.doi.org/10.3390/md16090330
Descripción
Sumario:As part of our research to discover novel bioactive natural products from marine microorganisms, five bagremycin analogues, including the previously unreported bagremycins F (1) and G (2), were isolated from a marine actinomycete Streptomyces sp. ZZ745. The structures of these compounds were determined by means of NMR spectroscopic analysis, HRESIMS data, and optical rotation. Both bagremycins F (1) and G (2) showed antibacterial activity against Escherichia coli, with MIC values of 41.8 and 61.7 μM, respectively.

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