New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp. ZZ745

As part of our research to discover novel bioactive natural products from marine microorganisms, five bagremycin analogues, including the previously unreported bagremycins F (1) and G (2), were isolated from a marine actinomycete Streptomyces sp. ZZ745. The structures of these compounds were determi...

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Detalles Bibliográficos
Autores principales: Zhang, Di, Shu, Chenyan, Lian, Xiaoyuan, Zhang, Zhizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163353/
https://www.ncbi.nlm.nih.gov/pubmed/30213054
http://dx.doi.org/10.3390/md16090330
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author Zhang, Di
Shu, Chenyan
Lian, Xiaoyuan
Zhang, Zhizhen
author_facet Zhang, Di
Shu, Chenyan
Lian, Xiaoyuan
Zhang, Zhizhen
author_sort Zhang, Di
collection PubMed
description As part of our research to discover novel bioactive natural products from marine microorganisms, five bagremycin analogues, including the previously unreported bagremycins F (1) and G (2), were isolated from a marine actinomycete Streptomyces sp. ZZ745. The structures of these compounds were determined by means of NMR spectroscopic analysis, HRESIMS data, and optical rotation. Both bagremycins F (1) and G (2) showed antibacterial activity against Escherichia coli, with MIC values of 41.8 and 61.7 μM, respectively.
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spelling pubmed-61633532018-10-11 New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp. ZZ745 Zhang, Di Shu, Chenyan Lian, Xiaoyuan Zhang, Zhizhen Mar Drugs Communication As part of our research to discover novel bioactive natural products from marine microorganisms, five bagremycin analogues, including the previously unreported bagremycins F (1) and G (2), were isolated from a marine actinomycete Streptomyces sp. ZZ745. The structures of these compounds were determined by means of NMR spectroscopic analysis, HRESIMS data, and optical rotation. Both bagremycins F (1) and G (2) showed antibacterial activity against Escherichia coli, with MIC values of 41.8 and 61.7 μM, respectively. MDPI 2018-09-12 /pmc/articles/PMC6163353/ /pubmed/30213054 http://dx.doi.org/10.3390/md16090330 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Zhang, Di
Shu, Chenyan
Lian, Xiaoyuan
Zhang, Zhizhen
New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp. ZZ745
title New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp. ZZ745
title_full New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp. ZZ745
title_fullStr New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp. ZZ745
title_full_unstemmed New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp. ZZ745
title_short New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp. ZZ745
title_sort new antibacterial bagremycins f and g from the marine-derived streptomyces sp. zz745
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163353/
https://www.ncbi.nlm.nih.gov/pubmed/30213054
http://dx.doi.org/10.3390/md16090330
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