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Genes for Membrane Transport Proteins: Not So Rare in Viruses
Some viruses have genes encoding proteins with membrane transport functions. It is unknown if these types of proteins are rare or are common in viruses. In particular, the evolutionary origin of some of the viral genes is obscure, where other viral proteins have homologs in prokaryotic and eukaryoti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163359/ https://www.ncbi.nlm.nih.gov/pubmed/30149667 http://dx.doi.org/10.3390/v10090456 |
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author | Greiner, Timo Moroni, Anna Van Etten, James L Thiel, Gerhard |
author_facet | Greiner, Timo Moroni, Anna Van Etten, James L Thiel, Gerhard |
author_sort | Greiner, Timo |
collection | PubMed |
description | Some viruses have genes encoding proteins with membrane transport functions. It is unknown if these types of proteins are rare or are common in viruses. In particular, the evolutionary origin of some of the viral genes is obscure, where other viral proteins have homologs in prokaryotic and eukaryotic organisms. We searched virus genomes in databases looking for transmembrane proteins with possible transport function. This effort led to the detection of 18 different types of putative membrane transport proteins indicating that they are not a rarity in viral genomes. The most abundant proteins are K(+) channels. Their predicted structures vary between different viruses. With a few exceptions, the viral proteins differed significantly from homologs in their current hosts. In some cases the data provide evidence for a recent gene transfer between host and virus, but in other cases the evidence indicates a more complex evolutionary history. |
format | Online Article Text |
id | pubmed-6163359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61633592018-10-11 Genes for Membrane Transport Proteins: Not So Rare in Viruses Greiner, Timo Moroni, Anna Van Etten, James L Thiel, Gerhard Viruses Article Some viruses have genes encoding proteins with membrane transport functions. It is unknown if these types of proteins are rare or are common in viruses. In particular, the evolutionary origin of some of the viral genes is obscure, where other viral proteins have homologs in prokaryotic and eukaryotic organisms. We searched virus genomes in databases looking for transmembrane proteins with possible transport function. This effort led to the detection of 18 different types of putative membrane transport proteins indicating that they are not a rarity in viral genomes. The most abundant proteins are K(+) channels. Their predicted structures vary between different viruses. With a few exceptions, the viral proteins differed significantly from homologs in their current hosts. In some cases the data provide evidence for a recent gene transfer between host and virus, but in other cases the evidence indicates a more complex evolutionary history. MDPI 2018-08-26 /pmc/articles/PMC6163359/ /pubmed/30149667 http://dx.doi.org/10.3390/v10090456 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Greiner, Timo Moroni, Anna Van Etten, James L Thiel, Gerhard Genes for Membrane Transport Proteins: Not So Rare in Viruses |
title | Genes for Membrane Transport Proteins: Not So Rare in Viruses |
title_full | Genes for Membrane Transport Proteins: Not So Rare in Viruses |
title_fullStr | Genes for Membrane Transport Proteins: Not So Rare in Viruses |
title_full_unstemmed | Genes for Membrane Transport Proteins: Not So Rare in Viruses |
title_short | Genes for Membrane Transport Proteins: Not So Rare in Viruses |
title_sort | genes for membrane transport proteins: not so rare in viruses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163359/ https://www.ncbi.nlm.nih.gov/pubmed/30149667 http://dx.doi.org/10.3390/v10090456 |
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