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RNAs as Candidate Diagnostic and Prognostic Markers of Prostate Cancer—From Cell Line Models to Liquid Biopsies

The treatment landscape of prostate cancer has evolved rapidly over the past five years. The explosion in treatment advances has been witnessed in parallel with significant progress in the field of molecular biomarkers. The advent of next-generation sequencing has enabled the molecular profiling of...

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Detalles Bibliográficos
Autores principales: Lim, Marvin C. J., Baird, Anne-Marie, Aird, John, Greene, John, Kapoor, Dhruv, Gray, Steven G., McDermott, Ray, Finn, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163368/
https://www.ncbi.nlm.nih.gov/pubmed/30200254
http://dx.doi.org/10.3390/diagnostics8030060
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author Lim, Marvin C. J.
Baird, Anne-Marie
Aird, John
Greene, John
Kapoor, Dhruv
Gray, Steven G.
McDermott, Ray
Finn, Stephen P.
author_facet Lim, Marvin C. J.
Baird, Anne-Marie
Aird, John
Greene, John
Kapoor, Dhruv
Gray, Steven G.
McDermott, Ray
Finn, Stephen P.
author_sort Lim, Marvin C. J.
collection PubMed
description The treatment landscape of prostate cancer has evolved rapidly over the past five years. The explosion in treatment advances has been witnessed in parallel with significant progress in the field of molecular biomarkers. The advent of next-generation sequencing has enabled the molecular profiling of the genomic and transcriptomic architecture of prostate and other cancers. Coupled with this, is a renewed interest in the role of non-coding RNA (ncRNA) in prostate cancer biology. ncRNA consists of several different classes including small non-coding RNA (sncRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA). These families are under active investigation, given their essential roles in cancer initiation, development and progression. This review focuses on the evidence for the role of RNAs in prostate cancer, and their use as diagnostic and prognostic markers, and targets for treatment in this disease.
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spelling pubmed-61633682018-10-11 RNAs as Candidate Diagnostic and Prognostic Markers of Prostate Cancer—From Cell Line Models to Liquid Biopsies Lim, Marvin C. J. Baird, Anne-Marie Aird, John Greene, John Kapoor, Dhruv Gray, Steven G. McDermott, Ray Finn, Stephen P. Diagnostics (Basel) Review The treatment landscape of prostate cancer has evolved rapidly over the past five years. The explosion in treatment advances has been witnessed in parallel with significant progress in the field of molecular biomarkers. The advent of next-generation sequencing has enabled the molecular profiling of the genomic and transcriptomic architecture of prostate and other cancers. Coupled with this, is a renewed interest in the role of non-coding RNA (ncRNA) in prostate cancer biology. ncRNA consists of several different classes including small non-coding RNA (sncRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA). These families are under active investigation, given their essential roles in cancer initiation, development and progression. This review focuses on the evidence for the role of RNAs in prostate cancer, and their use as diagnostic and prognostic markers, and targets for treatment in this disease. MDPI 2018-08-30 /pmc/articles/PMC6163368/ /pubmed/30200254 http://dx.doi.org/10.3390/diagnostics8030060 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lim, Marvin C. J.
Baird, Anne-Marie
Aird, John
Greene, John
Kapoor, Dhruv
Gray, Steven G.
McDermott, Ray
Finn, Stephen P.
RNAs as Candidate Diagnostic and Prognostic Markers of Prostate Cancer—From Cell Line Models to Liquid Biopsies
title RNAs as Candidate Diagnostic and Prognostic Markers of Prostate Cancer—From Cell Line Models to Liquid Biopsies
title_full RNAs as Candidate Diagnostic and Prognostic Markers of Prostate Cancer—From Cell Line Models to Liquid Biopsies
title_fullStr RNAs as Candidate Diagnostic and Prognostic Markers of Prostate Cancer—From Cell Line Models to Liquid Biopsies
title_full_unstemmed RNAs as Candidate Diagnostic and Prognostic Markers of Prostate Cancer—From Cell Line Models to Liquid Biopsies
title_short RNAs as Candidate Diagnostic and Prognostic Markers of Prostate Cancer—From Cell Line Models to Liquid Biopsies
title_sort rnas as candidate diagnostic and prognostic markers of prostate cancer—from cell line models to liquid biopsies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163368/
https://www.ncbi.nlm.nih.gov/pubmed/30200254
http://dx.doi.org/10.3390/diagnostics8030060
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