NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation

In sterile liver inflammation, danger signals are released in response to tissue injury to alert the immune system; e.g., by activation of the NLRP3 inflammasome. Recently, IL-33 has been identified as a novel type of danger signal or “alarmin”, which is released from damaged and necrotic cells. IL-...

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Detalles Bibliográficos
Autores principales: Neumann, Katrin, Schiller, Birgit, Tiegs, Gisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163521/
https://www.ncbi.nlm.nih.gov/pubmed/30213101
http://dx.doi.org/10.3390/ijms19092732
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author Neumann, Katrin
Schiller, Birgit
Tiegs, Gisa
author_facet Neumann, Katrin
Schiller, Birgit
Tiegs, Gisa
author_sort Neumann, Katrin
collection PubMed
description In sterile liver inflammation, danger signals are released in response to tissue injury to alert the immune system; e.g., by activation of the NLRP3 inflammasome. Recently, IL-33 has been identified as a novel type of danger signal or “alarmin”, which is released from damaged and necrotic cells. IL-33 is a pleiotropic cytokine that targets a broad range of immune cells and exhibits pro- and anti-inflammatory properties dependent on the disease. This review summarizes the immunomodulatory roles of the NLRP3 inflammasome and IL-33 in sterile liver inflammation and highlights potential therapeutic strategies targeting these pathways in liver disease.
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spelling pubmed-61635212018-10-10 NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation Neumann, Katrin Schiller, Birgit Tiegs, Gisa Int J Mol Sci Review In sterile liver inflammation, danger signals are released in response to tissue injury to alert the immune system; e.g., by activation of the NLRP3 inflammasome. Recently, IL-33 has been identified as a novel type of danger signal or “alarmin”, which is released from damaged and necrotic cells. IL-33 is a pleiotropic cytokine that targets a broad range of immune cells and exhibits pro- and anti-inflammatory properties dependent on the disease. This review summarizes the immunomodulatory roles of the NLRP3 inflammasome and IL-33 in sterile liver inflammation and highlights potential therapeutic strategies targeting these pathways in liver disease. MDPI 2018-09-12 /pmc/articles/PMC6163521/ /pubmed/30213101 http://dx.doi.org/10.3390/ijms19092732 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Neumann, Katrin
Schiller, Birgit
Tiegs, Gisa
NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation
title NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation
title_full NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation
title_fullStr NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation
title_full_unstemmed NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation
title_short NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation
title_sort nlrp3 inflammasome and il-33: novel players in sterile liver inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163521/
https://www.ncbi.nlm.nih.gov/pubmed/30213101
http://dx.doi.org/10.3390/ijms19092732
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