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Assessment of Skeletal Tumor Load in Metastasized Castration-Resistant Prostate Cancer Patients: A Review of Available Methods and an Overview on Future Perspectives

Metastasized castration-resistant prostate cancer (mCRPC), is the most advanced form of prostate neoplasia, where massive spread to the skeletal tissue is frequent. Patients with this condition are benefiting from an increasing number of treatment options. However, assessing tumor response in patien...

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Autores principales: Fiz, Francesco, Dittman, Helmut, Campi, Cristina, Morbelli, Silvia, Marini, Cecilia, Brignone, Massimo, Bauckneht, Matteo, Piva, Roberta, Massone, Anna Maria, Piana, Michele, Sambuceti, Gianmario, la Fougère, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163573/
https://www.ncbi.nlm.nih.gov/pubmed/30060546
http://dx.doi.org/10.3390/bioengineering5030058
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author Fiz, Francesco
Dittman, Helmut
Campi, Cristina
Morbelli, Silvia
Marini, Cecilia
Brignone, Massimo
Bauckneht, Matteo
Piva, Roberta
Massone, Anna Maria
Piana, Michele
Sambuceti, Gianmario
la Fougère, Christian
author_facet Fiz, Francesco
Dittman, Helmut
Campi, Cristina
Morbelli, Silvia
Marini, Cecilia
Brignone, Massimo
Bauckneht, Matteo
Piva, Roberta
Massone, Anna Maria
Piana, Michele
Sambuceti, Gianmario
la Fougère, Christian
author_sort Fiz, Francesco
collection PubMed
description Metastasized castration-resistant prostate cancer (mCRPC), is the most advanced form of prostate neoplasia, where massive spread to the skeletal tissue is frequent. Patients with this condition are benefiting from an increasing number of treatment options. However, assessing tumor response in patients with multiple localizations might be challenging. For this reason, many computational approaches have been developed in the last decades to quantify the skeletal tumor burden and treatment response. In this review, we analyzed the progressive development and diffusion of such approaches. A computerized literature search of the PubMed/Medline was conducted, including articles between January 2008 and March 2018. The search was expanded by manually reviewing the reference list of the chosen articles. Thirty-five studies were identified. The number of eligible studies greatly increased over time. Studies could be categorized in the following categories: automated analysis of 2D scans, SUV-based thresholding, hybrid CT- and SUV-based thresholding, and MRI-based thresholding. All methods are discussed in detail. Automated analysis of bone tumor burden in mCRPC is a growing field of research; when choosing the appropriate method of analysis, it is important to consider the possible advantages as well as the limitations thoroughly.
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spelling pubmed-61635732018-10-11 Assessment of Skeletal Tumor Load in Metastasized Castration-Resistant Prostate Cancer Patients: A Review of Available Methods and an Overview on Future Perspectives Fiz, Francesco Dittman, Helmut Campi, Cristina Morbelli, Silvia Marini, Cecilia Brignone, Massimo Bauckneht, Matteo Piva, Roberta Massone, Anna Maria Piana, Michele Sambuceti, Gianmario la Fougère, Christian Bioengineering (Basel) Review Metastasized castration-resistant prostate cancer (mCRPC), is the most advanced form of prostate neoplasia, where massive spread to the skeletal tissue is frequent. Patients with this condition are benefiting from an increasing number of treatment options. However, assessing tumor response in patients with multiple localizations might be challenging. For this reason, many computational approaches have been developed in the last decades to quantify the skeletal tumor burden and treatment response. In this review, we analyzed the progressive development and diffusion of such approaches. A computerized literature search of the PubMed/Medline was conducted, including articles between January 2008 and March 2018. The search was expanded by manually reviewing the reference list of the chosen articles. Thirty-five studies were identified. The number of eligible studies greatly increased over time. Studies could be categorized in the following categories: automated analysis of 2D scans, SUV-based thresholding, hybrid CT- and SUV-based thresholding, and MRI-based thresholding. All methods are discussed in detail. Automated analysis of bone tumor burden in mCRPC is a growing field of research; when choosing the appropriate method of analysis, it is important to consider the possible advantages as well as the limitations thoroughly. MDPI 2018-07-28 /pmc/articles/PMC6163573/ /pubmed/30060546 http://dx.doi.org/10.3390/bioengineering5030058 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fiz, Francesco
Dittman, Helmut
Campi, Cristina
Morbelli, Silvia
Marini, Cecilia
Brignone, Massimo
Bauckneht, Matteo
Piva, Roberta
Massone, Anna Maria
Piana, Michele
Sambuceti, Gianmario
la Fougère, Christian
Assessment of Skeletal Tumor Load in Metastasized Castration-Resistant Prostate Cancer Patients: A Review of Available Methods and an Overview on Future Perspectives
title Assessment of Skeletal Tumor Load in Metastasized Castration-Resistant Prostate Cancer Patients: A Review of Available Methods and an Overview on Future Perspectives
title_full Assessment of Skeletal Tumor Load in Metastasized Castration-Resistant Prostate Cancer Patients: A Review of Available Methods and an Overview on Future Perspectives
title_fullStr Assessment of Skeletal Tumor Load in Metastasized Castration-Resistant Prostate Cancer Patients: A Review of Available Methods and an Overview on Future Perspectives
title_full_unstemmed Assessment of Skeletal Tumor Load in Metastasized Castration-Resistant Prostate Cancer Patients: A Review of Available Methods and an Overview on Future Perspectives
title_short Assessment of Skeletal Tumor Load in Metastasized Castration-Resistant Prostate Cancer Patients: A Review of Available Methods and an Overview on Future Perspectives
title_sort assessment of skeletal tumor load in metastasized castration-resistant prostate cancer patients: a review of available methods and an overview on future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163573/
https://www.ncbi.nlm.nih.gov/pubmed/30060546
http://dx.doi.org/10.3390/bioengineering5030058
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